Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Endpoint summary

Administrative data

Description of key information

Additional information

In Annex X of the Regulation (EC) No 1907/2006 REACH concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH), it is suggested, that in case of long-term toxicity testing to birds "any need for testing should be carefully considered taking into account the large mammalian dataset that is usually available at this tonnage level." Furthermore, ECHA (2008) states in the "Guidance on information requirements and chemical safety assessment Chapter R.7c" that "given that mammalian toxicity is considered in detail for human health protection, the need for additional data for birds must be considered very carefully – new tests are a last resort in the data collection process." Taking this into account, long-term or reproductive toxicity tests on birds do not need to be conducted due to the facts that a mammalian dataset is available and direct exposure to soil is unlikely.

The reaction mass is not readily biodegradable. However, since the test substance has a low potential for adsorption no significant adsorption to the soil phase is expected. The risk of bioaccumulation is low based on the log Kow as well as the estimated BCF values of the major components of the reaction mass as well as the experimentally determined BCF of piperazine, which was smaller than 4 (NITE, 1979). The substance is not classified according to DSD/DPD and GHS. Furthermore, results with aquatic organisms revealed only little harmful effects of the test substance (NOEC > 1 mg/L). Therefore, studies with terrestrial organisms do not need to be conducted.

Risk assessment has been performed based on the equilibrium partitioning method (EPM).