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Toxicological information

Sensitisation data (human)

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Administrative data

Endpoint:
sensitisation data (humans)
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Piperazine-Induced Occupational Asthma
Author:
Hagmar L., et al
Year:
1982
Bibliographic source:
Journal of Occupational Medicine, Vol. 24, No 3

Materials and methods

Type of sensitisation studied:
respiratory
Study type:
survey
Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Survey of workers in a chemical factory.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): piperazine
- Analytical purity: no data

Method

Type of population:
occupational
Ethical approval:
not specified
Subjects:
- Number of subjects exposed: 130
- Sex: 129 males, 1 female

Route of administration:
inhalation

Results and discussion

Results of examinations:
About one third of the workers in the group with the highest exposures, suffered from symptoms of asthma, and a dose-response relationship was evident for the studied cohort.

Any other information on results incl. tables

Eleven persons presently employed were asthmatic or had experienced asthma associated with exposure to chemicals. In 13 former employees medical reports supported the diagnosis of occupational asthma associated with chemicals. The criteria for diagnosis was recurrent dyspnoea with wheezing breathing and coughing, in association with exposure to agent. The agent was judged to be piperazine in 29 persons and ethylene diamine in 3 persons.

Applicant's summary and conclusion

Conclusions:
Piperazine is a respiratory sensitiser in Human.
Executive summary:

In a survey of workers in a chemical factory inquiries among the employees regarding airway symptoms, smoking habits and chronic bronchitis were conducted. From 130 subject exposed it was judged that 29 persons developed occupational asthma due to exposure of piperazine.