Registration Dossier

Ecotoxicological information

Toxicity to soil microorganisms

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
toxicity to soil microorganisms
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Justification for type of information:
REPORTING FORMAT FOR THE ANALOGUE APPROACH

1. HYPOTHESIS FOR THE ANALOGUE APPROACH
This read-across is based on the hypothesis that source and target substances have similar toxicological properties because
• they are manufactured from similar or identical precursors under similar conditions
• they share structural similarities with common functional groups: quaternary ammonium and saturated or unsaturated alkyl chains with comparable length (corresponding to scenario 2 of the read-across assessment framework)

The read-across hypothesis is based on structural similarity of target and source substances. Based on available experimental data, including key physicochemical properties and data from acute toxicity, irritation, sensitization (human) and genotoxicity studies, the read-across strategy is supported by a quite similar toxicological profile of all substances.

Therefore, read-across from the existing ecotoxicity, environmental fate and toxicity studies conducted with the source substances is considered as an appropriate adaptation to the standard information requirements of the REACH Regulation for the target substance, in accordance with the provisions of Annex XI, 1.5 of the REACH Regulation.

A justification for read-across is attached to IUCLID section 13.

2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
See justification for read-across attached to IUCLID section 13.

3. ANALOGUE APPROACH JUSTIFICATION
See justification for read-across attached to IUCLID section 13.

4. DATA MATRIX
See justification for read-across attached to IUCLID section 13.
Reason / purpose:
read-across: supporting information
Reason / purpose:
read-across source
Test organisms (inoculum):
soil
Duration:
14 wk
Dose descriptor:
NOEC
Effect conc.:
400 mg/kg soil dw
Basis for effect:
respiration rate
Duration:
28 d
Dose descriptor:
NOEC
Effect conc.:
365 mg/kg soil dw
Basis for effect:
respiration rate

Description of key information

Key value for chemical safety assessment

Long-term EC10 or NOEC for soil microorganisms:
400 mg/kg soil dw

Additional information

No experimental data are available for the target substance Di-C12-18 alkyldimethyl ammonium chloride. However, two toxicity studies with soil microorganisms are available for the closely related source substance DHTDMAC. A justification for read-across is attached to IUCLID section 13.

 

No effects on respiration rate or carbon dioxide production were observed at concentrations of 365 and 400 mg/ kg soil dw, respectively.