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EC number: 947-726-2 | CAS number: -
EC50 = 30 µg/L, 5 d NOEC = 31 µg/L (read-across from DODMAC and DHTDMAC)
No experimental data are available for the target substance Di-C12-18 alkyldimethyl ammonium chloride. However, toxicity studies in algae are available for the closely related source substances DODMAC and DHTDMAC. A justification for read-across is attached to IUCLID section 13.
Several references are cited in EU RAR, 2002:
“The toxicity of DODMAC for Selenastrum capricornutum and Microcystis aeruginosa in laboratory water was investigated according to an ASTM method (Lewis & Hamm, 1986). For growth reduction after 96h the EC50 was 0.06 mg/l for Selenastrum capricornutum and 0.05 mg/l for Microcystis aeruginosa (nominal concentrations; pH = 6.8 - 7.2, hardness = 131 - 146 mg/l CaCO3).
An algae study with DODMAC in filtered natural water of the Little Miami River, OH (5.4 mg/l total organic carbon, pH = 8.1 - 8.4, hardness = 171 mg/l CaCO3) was conducted by Versteeg & Shorter, 1993. ForSelenastrum capricornutuma 96h EC50 of 1.12 mg/l was derived for growth reduction (measured concentration) and the algistatic concentration was above 16.4 mg/l. In this study acidic methanol was used as carrier solvent, which had a growth stimulating effect on the algae.”
“The influence of different test media on the sensitivity of Selenastrum capricornutum towards DHTDMAC (71.4% active ingredient) was investigated by EG & G Bionomics, 1981 b,c,d. Laboratory water with a hardness of 20 mg/l CaCO3 (no further characterization) and algae nutrient enriched White River water (Indiana) of the following quality prior to autoclaving were used: pH = 7.3, total hardness = 299 mg/l CaCO3, 68 mg/l suspended solids, 0.2 µg/l MBAS) In laboratory water a NOEC of 0.078 mg/l and an algistatic concentration of 0.228 mg/l were derived for the reduction of cell number after 5 days (nominal concentrations of active ingredient). The corresponding values for the river water were: NOEC = 0.062 mg/l and algistatic concentration = 0.708 mg/l. The table shows that results for Microcystis aeruginosa are similar (EG & G Bionomics, 1981 b,c,d).” (EU RAR, 2002)
0.708 mg/l nominal conc.
The target and the source substances have a low water solubility and form complexes with dissolved organics, especially with anionic compounds. Thus, results with natural river water are considered more realistic and more relevant than the results obtained with laboratory water.
For classification and labelling purposes the 96h EC50 of 1.12 mg/L obtained in the river water study conducted with DODMAC cannot be used, as in this study acidic methanol was used as vehicle, which had a growth stimulating effect on the algae. Thus, the EC50 of 0.06 mg/L for Selenastrum capricornutum was used, although this study was conducted in laboratory water.
From the QSAR data on short-term toxicity to fish and Daphnia (no model is available for algae) it was deduced, that the target substance should be expected to be more toxic than the source substances DODMAC and DHTDMAC, and a factor of approx. 2 should be applied to the EC50 and NOEC obtained in this study. Thus, the EC50 and NOEC of the target substance Di-C12-18 alkyldimethyl ammonium chloride are considered to be 0.03 and 0.031 mg/L.
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