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EC number: 947-726-2
CAS number: -
NOEC = 0.027 mg/L (read-across from DTDMAC)
experimental data are available for the target substance Di-C12-18
alkyldimethyl ammonium chloride.
However, long-term toxicity studies in fish are available for the
closely related source substance DTDMAC.
A justification for read-across is attached to IUCLID section 13.
the long-term toxicity of DTDMAC embryo larval tests were conducted with
Pimephales promelas in filtered well water and natural river water.
Exposure was initiated within 48 hours after fertilization and continued
through 30 days post hatch in a flow-through system. In well water the
most sensitive parameters were mean percent survival, length and weight
of larvae. The NOEC was 0.053 mg/l (measured concentration) after 34
days test duration. In river water the NOEC for the most sensitive
parameters hatchability and mean weight of larvae was 0.23 mg/l after 33
days test duration. The river water (Town River) had the following
characteristics: pH = 6.4 - 6.9, total hardness = 62 mg/l CaCO3, 9.4
mg/l suspended solids, 0.59 mg/l MBAS and triethyleneglycol was used as
carrier solvent. The well water had a hardness of 28 -31 mg/l CaCO3, pH
= 6.8-7.6 and isopropanol was used as carrier solvent. In well water the
measured concentrations were equal to the nominal concentrations whereas
in river water measured concentrations averaged 45-67% of the nominal
QSAR data on short-term toxicity it was deduced, that the target
substance should be expected to be more toxic than the source substance
DTDMAC, and a factor of approx. 2 should be applied to the NOEC obtained
in this study. Thus, the NOEC of the
target substance Di-C12-18
alkyldimethyl ammonium chloride is considered to be 0.027 mg/L.
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