Registration Dossier

Administrative data

Description of key information

Two experimental studies with rabbits reported skin irritating effects for tetrahydronaphthalene, also in a dermal toxicity study a skin irritating effect was observed in rats.
Two experimental studies with rabbits showed no or mild and reversible eye irritation.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Additional information

Cited from SIAR for19 (19-22 October 2004):

Skin irritation

Studies in Animals

In a study according to OECD TG 404 with rabbits (Small white Russian), undiluted 1,2,3,4-tetrahydronaphthalene caused moderate irritation with Draize scores of 3.11 for erythema, 1.56 for edema, and 4.55 in total. Effects were not completely reversible within 14 days (Hüls AG, 1984 b).

Similar irritation intensity was observed in an early and limited study published by Smyth, Carpenter and Weil (1951) as well as by Union Carbide Corp. (1992). They report an irritation index of 4/10 in rabbits 24 hours after application of 0.01 ml 1,2,3,4-tetrahydronaphthalene to the clipped belly of rabbits (no information on occlusion).

Studies in Humans

A skin condition similar to turpentine-induced dermatitis that was eczematous in nature is reported in five painters (four males, one female) that used 1,2,3,4-tetrahydronaphthalene (1 case) or mixtures containing 1,2,3,4-tetrahydronaphthalene as substitutes for turpentine. From the rare occurrence of the symptoms, the author concluded that the persons probably had a high sensitivity (Galewsky, 1922).

Eye Irritation

Studies in Animals

In a study according to OECD TG 405 with rabbits (Small white Russian), undiluted 1,2,3,4-tetrahydronaphthalene caused no significant irritation with Draize scores of 5.17/110. Effects were completely reversible within 6 days (Hüls AG, 1984 a). Similar irritation intensity was observed in an early study published by Smyth, Carpenter and Weil (1951) as well as by Union Carbide Corp. (1992). They report an irritation index of 1/10 in rabbits 18-24 hours after application of 0.5 ml 1,2,3,4-tetrahydronaphthalene to rabbits (not rinsed).

Studies in Humans

Two painters who had been painting for three days with 1,2,3,4-tetrahydronaphthalene-containing varnishes in a poorly ventilated area complained, among others, about irritation of mucous membranes and profuse lacrimation (Arnstein, 1922).

 

Respiratory Tract Irritation

There were no studies available in animals or humans

 

Conclusion

1,2,3,4-Tetrahydronaphthalene was a moderate irritant to the skin (OECD TG 404) but not to the eye (OECD TG 405). However, high exposure from the gas phase may cause irritation of mucous membranes and profuse lacrimation in humans.

 


Effects on skin irritation/corrosion: irritating

Justification for classification or non-classification

Based on the experimental data tetrahydronaphthalene requires classification and labelling as skin irritant and does not require classification and labelling as eye irritant.