Registration Dossier

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Documentation very brief

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1949
Report Date:
1949
Reference Type:
publication
Title:
Range-finding toxicity data: list IV
Author:
Smyth HF Jr, Carpenter CP and Weil CS
Year:
1951
Bibliographic source:
Arch. Ind. Hyg. Occup. Med. 4, 119-122

Materials and methods

Principles of method if other than guideline:
Method: other: Smyth HF Jr, Carpenter CP (1944): The place of the range finding test in the industrial toxicology laboratory. J. Ind. Hyg. Toxicol. 26, 269-273 and subsequent updates
GLP compliance:
no
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
tetrahydronaphthalene procured from Eastman Kodak Co. under their number P550 on 10 Jan. 1949. No data on purity

Test animals

Species:
rat
Strain:
not specified
Sex:
male

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
not specified
Details on inhalation exposure:
Animals were exposed to saturated vapor at 20°C or a mist generated at 170°C
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
8 h
Concentrations:
ca. 1.8 mg/l and higher
No. of animals per sex per dose:
6
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LC50
Effect level:
> 1.8 mg/L air
Exp. duration:
8 h

Applicant's summary and conclusion

Conclusions:
In an inhalation experiment rats showed no mortalities at 8h exposure to saturated vapour at 20°C or a mist generated at 170°C. Thus tetrahydronaphthalene showed low acute toxicity in rats after inhalation.
Executive summary:

Groups of 6 rats each tolerated 8 hour exposure to substantially saturated vapour at room temperature (calculated at 1.8 mg tetrahydronaphthalene per litre air considering a vapour pressure of 34 Pa at 20°C) or to mist generated by aerating the compound while it was heated at 170°C (corresponding to 10.5 mg/L with a vapour pressur of 290 Pa at 170°C)