1,2,3,4-tetrahydronaphthalene

Repeated dose toxicity: other routes

Administrative data

Endpoint:

short-term repeated dose toxicity: other route

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

publication

Title:

Über die Wirkungen von Tetralin, 5-Tetralol und 5-Tetralon auf Körpertemperatur und Stoffwechsel

Author:

Kanitz HR, Lohmeyer A and Scholz J

Year:

1935

Bibliographic source:

Arch. Hyg. Bak. 113, 234-244

Materials and methods

Principles of method if other than guideline:

See Test Conditions

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Tetralin

IUPAC Name:

Tetralin

Constituent 2

Reference substance name:

1,2,3,4-tetrahydronaphthalene

EC Number:

204-340-2

EC Name:

1,2,3,4-tetrahydronaphthalene

Cas Number:

119-64-2

Molecular formula:

C10H12

IUPAC Name:

1,2,3,4-tetrahydronaphthalene

Details on test material:

purified 1,2,3,4-Tetrahydronaphthalene

Test animals

Species:

rat

Strain:

not specified

Sex:

male

Details on test animals or test system and environmental conditions:

TEST ORGANISMS
- Weight at study initiation: range 170-270 g (adults)
- Number of animals: 2 per route of application, total 6

Administration / exposure

Route of administration:

other: oral feed / s.c. / i.v.

Details on exposure:

ADMINISTRATION / EXPOSURE 
- Duration of test/exposure:    Days 1, 6, 12-22
- Type of exposure: oral, s.c., or i.v.

Duration of treatment / exposure:

1+1+11 days (no treatment on days 2-5 and 7-11)

Frequency of treatment:

13 times

Doses / concentrations

Remarks:

Doses / Concentrations:
0.1 ml/animal and application

Control animals:

other: no data specified

Details on study design:

Post-exposure period: 6 days

Examinations

Observations and examinations performed and frequency:

CLINICAL OBSERVATIONS AND FREQUENCY: 
- Body weight: daily
- Food consumption: daily
- Urinalysis: daily 24 hour-samples analyzed for nitrogen, carbon, and  chemical oxygen demand

Sacrifice and pathology:

ORGANS EXAMINED AT NECROPSY (MACROSCOPIC AND MICROSCOPIC): 
- Macroscopic: liver, kidney, others not listed
- Microscopic: liver, kidney

Results and discussion

Results of examinations

Clinical signs:

no effects observed

Mortality:

no mortality observed

Body weight and weight changes:

effects observed, treatment-related

Food consumption and compound intake (if feeding study):

effects observed, treatment-related

Description (incidence and severity):

reduced feed intake

Food efficiency:

not specified

Water consumption and compound intake (if drinking water study):

effects observed, treatment-related

Details on results:

TOXIC RESPONSE/EFFECTS BY DOSE LEVEL: 
- Mortality and time to death: No mortalities
- Food/water consumption: Decreased (not quantified)
- Urinalysis:    Variations in quantity;    Nitrogen concentration approximately constant, increased upon repeated  exposure indicating increase of 
protein conversion rate;    Carbon  content and COD significantly increased;    No proteins found;    Dark discoloration only after repeated 
application or after application  of test substance not purified from hydroperoxides.
- Gross pathology: Yellow stained, slightly swelled kidneys and livers
- Histopathology: No findings in kidneys and livers

Target system / organ toxicity

Critical effects observed:

not specified