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Toxicological information

Repeated dose toxicity: other routes

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Administrative data

Endpoint:
short-term repeated dose toxicity: other route
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
Über die Wirkungen von Tetralin, 5-Tetralol und 5-Tetralon auf Körpertemperatur und Stoffwechsel
Author:
Kanitz HR, Lohmeyer A and Scholz J
Year:
1935
Bibliographic source:
Arch. Hyg. Bak. 113, 234-244

Materials and methods

Principles of method if other than guideline:
See Test Conditions
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Details on test material:
purified 1,2,3,4-Tetrahydronaphthalene

Test animals

Species:
rat
Strain:
not specified
Sex:
male
Details on test animals and environmental conditions:
TEST ORGANISMS
- Weight at study initiation: range 170-270 g (adults)
- Number of animals: 2 per route of application, total 6

Administration / exposure

Route of administration:
other: oral feed / s.c. / i.v.
Details on exposure:
ADMINISTRATION / EXPOSURE 
- Duration of test/exposure:    Days 1, 6, 12-22
- Type of exposure: oral, s.c., or i.v.
Duration of treatment / exposure:
1+1+11 days (no treatment on days 2-5 and 7-11)
Frequency of treatment:
13 times
Doses / concentrations
Remarks:
Doses / Concentrations:
0.1 ml/animal and application
Control animals:
other: no data specified
Details on study design:
Post-exposure period: 6 days

Examinations

Observations and examinations performed and frequency:
CLINICAL OBSERVATIONS AND FREQUENCY: 
- Body weight: daily
- Food consumption: daily
- Urinalysis: daily 24 hour-samples analyzed for nitrogen, carbon, and  chemical oxygen demand
Sacrifice and pathology:
ORGANS EXAMINED AT NECROPSY (MACROSCOPIC AND MICROSCOPIC): 
- Macroscopic: liver, kidney, others not listed
- Microscopic: liver, kidney

Results and discussion

Results of examinations

Clinical signs:
no effects observed
Mortality:
no mortality observed
Body weight and weight changes:
effects observed, treatment-related
Food consumption and compound intake (if feeding study):
effects observed, treatment-related
Description (incidence and severity):
reduced feed intake
Food efficiency:
not specified
Water consumption and compound intake (if drinking water study):
effects observed, treatment-related
Details on results:
TOXIC RESPONSE/EFFECTS BY DOSE LEVEL: 
- Mortality and time to death: No mortalities
- Food/water consumption: Decreased (not quantified)
- Urinalysis:    Variations in quantity;    Nitrogen concentration approximately constant, increased upon repeated  exposure indicating increase of 
protein conversion rate;    Carbon  content and COD significantly increased;    No proteins found;    Dark discoloration only after repeated 
application or after application  of test substance not purified from hydroperoxides.
- Gross pathology: Yellow stained, slightly swelled kidneys and livers
- Histopathology: No findings in kidneys and livers

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion