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Environmental fate & pathways

Hydrolysis

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Reference
Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Qualifier:
according to
Guideline:
OECD Guideline 111 (Hydrolysis as a Function of pH)
GLP compliance:
yes
Radiolabelling:
not specified
Analytical monitoring:
yes
Buffers:
Buffer solution were sterilized through the 0.2 μm cellulose acetate filter. The composition of buffer solutions was as follows:- pH 4.0 : 0.1 N NaOH 0.4 mL + 0.1 M Potassium biphthalate 50 mL Dissolved in deionized water and made up to 100 mL- pH 7.0 : 0.1 N NaOH 29.63ml + 0.1 M Monopotassium 50 mL Dissolved in deionized water and made up to 100 mL- pH 9.0 : 0.1 N NaOH 21.3ml + 0.1 Boric acid in 0.1 M KCl 50 mL Dissolved in deionized water and made up to 100 mL
Details on test conditions:
All glassware used in the hydrosis test were sterilized and buffer solutions were taken to avoid oxygen and all of the Hydrosis test was carried out under dark condition.
Preliminary study:
Triplicate sterile aqueous buffer solutions (250 mL) of different pH values of 4.0, 7.0 and 9.0 were treatedwith test substance to make 50 ppm.The test was performed at 50 +/- 5 deg C for 5 days. Individual replicate samples were sampled at application (0 day) and 5 days.And samples were quantified by HPLC.
Transformation products:
no
pH:
4
Temp.:
50 °C
DT50:
> 1 yr
Type:
(pseudo-)first order (= half-life)
Remarks on result:
other: The hydrolysis of the substance was less than 10% over the 5 days, so a definitive test was not performed. Based on these results,S-allyl O-pentyl dithiocarbonate was hydrolytically stable (half life > 1 year) specified by the OECD Guidelines.
pH:
7
Temp.:
50 °C
DT50:
> 1 yr
Type:
(pseudo-)first order (= half-life)
Remarks on result:
other: The hydrolysis of the substance was less than 10% over the 5 days, so a definitive test was not performed. Based on these results,S-allyl O-pentyl dithiocarbonate was hydrolytically stable (half life > 1 year) specified by the OECD Guidelines.
pH:
9
Temp.:
50 °C
DT50:
> 1 yr
Type:
(pseudo-)first order (= half-life)
Remarks on result:
other: The hydrolysis of the substance was less than 10% over the 5 days, so a definitive test was not performed. Based on these results,S-allyl O-pentyl dithiocarbonate was hydrolytically stable (half life > 1 year) specified by the OECD Guidelines.
Details on results:
The preliminary test results showed that the percent hydrolysis at pH 4.0, 7.0 and 9.0 were negative values after 5 days respectively. These results were less than 10% of hydrolysis and then test substance was considered hydrolytically stable and no additional testing was requiredby the OECD Guidelines.
Results with reference substance:
Concentration of S-allyl O-pentyl dithiocarbonatate at 0 day
Validity criteria fulfilled:
yes
Conclusions:
Since the chemical is degradable less than 10% after 5 days in this test condition, it is presumably stable in water. (Hydrolytically stable)
Hydrolysis does not appear to be significant dissipation pathway for S-allyl O-pentyl dithiocarbonate.
Executive summary:

This study was performed following “OECD Guidelines for Testing of Chemicals No. 111: Hydrolysis as function of pH. The preliminary test was performed at 50 ±5°C and pH 4, 7 and pH 9. The hydrolysis of the substance was less than 10% over the 5 days, so a definitive test was not performed. Based on these results, S-allyl O-pentyl dithiocarbonate was hydrolytically stable (half life > 1 year) specified by the OECD Guidelines

Description of key information

Hydrolysis does not appear to be significant dissipation pathway for S-allyl O-pentyl dithiocarbonate.

Key value for chemical safety assessment

Half-life for hydrolysis:
1 yr
at the temperature of:
50 °C

Additional information

The study of MOE 2008 was performed following “OECD Guidelines for Testing of Chemicals No. 111: Hydrolysis as function of pH. The preliminary test was performed at 50 ±5°C and pH 4, 7 and pH 9. The hydrolysis of the substance was less than 10% over the 5 days, so a definitive test was not performed. Based on these results,S-allyl O-pentyl dithiocarbonatewas hydrolytically stable (half life > 1 year) specified by the OECD Guidelines .