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Toxicity to other above-ground organisms

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Endpoint:
toxicity to other above-ground organisms
Type of information:
other: published data
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Justification for type of information:
Carbon disulphide (CAS number 75–15–0) is both reagents used in the manufacture of S-allyl O-pentyl dithiocarbonate. Therefore, Carbon disulphide (CAS number 75–15–0) need to be considered in the assessment of S-allyl O-pentyl dithiocarbonate.
Qualifier:
according to
Guideline:
EPA OPP 71-3 (Wild Mammal Acute Toxicity Test)
GLP compliance:
yes
Analytical monitoring:
no
Vehicle:
no
Test organisms (species):
mouse
Details on test organisms:
TEST ORGANISMS:
Mus musculus (House Mouse). The organism(s) (age: 5 wk and organism characteristics of: SPF, DDY STRAIN)
Study type:
laboratory study
Limit test:
no
Total exposure duration:
24 h
Test temperature:
10-20 0C
Temperature was continuously recorded
Photoperiod and lighting:
They were held at a photoperiod of 14:10 light:dark.
Details on test conditions:
The organism(s) -Mus musculus (House Mouse). The organism(s) (age: 5 wk and organism characteristics of: SPF, DDY STRAIN) were exposed for a duration of 24 hour(s) to a(n) 1 dosed x time(s) per study period application of Carbon disulfide (CAS # 75150) in Olive oil, Olive oil carrier through a(n) intraperitoneal exposure route. The reported chemical concentrations are the result of unmeasured analysis of chemical solutions and are based on the NR ion.
Nominal and measured concentrations:
DOSES/500/1000/1500/2000 mg/kg//
Reference substance (positive control):
no
Duration:
24 h
Dose descriptor:
other: NOEL
Effect conc.:
500 mg/kg bw
Nominal / measured:
nominal
Conc. based on:
act. ingr.
Basis for effect:
growth
Remarks on result:
other: Weight gain
Duration:
24 h
Dose descriptor:
NOEC
Effect conc.:
4 150 mg/kg diet
Nominal / measured:
nominal
Conc. based on:
act. ingr.
Remarks:
TheNOELs can be converted to NOECs with the following two formulae:   NOECmouse=NOELmouse.CONVmouse  Conversion factors from NOEL to NOEC for mammalian species Mus musculus is 8.3 (bw/dfi)  
Basis for effect:
growth
Remarks on result:
other: Conversion factors from NOEL to NOEC for mammalian species Mus musculus is 8.3 (bw/dfi)  NOECmouse=500 x 8.3=4150 mg/kg/diet
Duration:
24 h
Dose descriptor:
other: NOEL
Effect conc.:
1 342.11 mg/kg bw
Nominal / measured:
nominal
Conc. based on:
test mat.
Remarks:
S-allyl O-pentyl dithiocarbonate
Basis for effect:
growth
Remarks on result:
other: On a molecular weight scaled basis, the NOEL would be 1342.11 mg/kg bw. (500x 204.35) /76.13 =1342.11mg/kg bw
Duration:
24 h
Dose descriptor:
NOEC
Effect conc.:
11 031.53 mg/kg diet
Nominal / measured:
nominal
Conc. based on:
test mat.
Remarks:
S-allyl O-pentyl dithiocarbonate
Basis for effect:
growth
Remarks on result:
other: Conversion factors from NOEL to NOEC for mammalian species Mus musculus is 8.3 (bw/dfi)  NOECmouse=1342.11x 8.3=11395.13 mg/kg/diet
Details on results:
For the assessment of secondary poisoning, the results always have to be expressed as the concentration in food in order to be able to compare it to the PEC.
TheNOELs can be converted to NOECs with the following two formulae:
 

NOECmouse=NOELmouse.CONVmouse
 
Conversion factors from NOEL to NOEC for mammalian species Mus musculus is 8.3 (bw/dfi)
 
bw = body weight (g); dfi: daily food intake (g/day)
 
NOECmouse=500x 8.3=4150 mg/kg/diet

A study of NC-NC Not Coded duration using no substrate media was conducted in a LAB site location with Not Coded obtained Mus musculus (House Mouse). The organism(s) (age: 5 wk and organism characteristics of: SPF, DDY STRAIN) were exposed for a duration of 24 hour(s) to a(n) 1 dosed x time(s) per study period application of Carbon disulfide (CAS # 75150) in Olive oil, Olive oil carrier through a(n) intraperitoneal exposure route. The reported chemical concentrations are the result of unmeasured analysis of chemical solutions and are based on the NR ion. (Reference 98738, Masuda,Y., M. Yasoshima, and N. Nakayama, 1986, Test Number 446233).

Validity criteria fulfilled:
yes
Conclusions:
For the assessment of secondary poisoning, the results always have to be expressed as the concentration in food in order to be able to compare it to the PEC.
TheNOELs can be converted to NOECs with the following two formulae:
 

NOECmouse=NOELmouse.CONVmouse
 
Conversion factors from NOEL to NOEC for mammalian species Mus musculus is 8.3 (bw/dfi)
 
bw = body weight (g); dfi: daily food intake (g/day)
 
NOECmouse=500x 8.3=4150 mg/kg/diet
Endpoint:
toxicity to other above-ground organisms
Type of information:
other: published data
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Qualifier:
equivalent or similar to
Guideline:
EPA OPP 71-3 (Wild Mammal Acute Toxicity Test)
GLP compliance:
not specified
Specific details on test material used for the study:
Carbon disulphide (CAS number 75–15–0) is both reagents used in the manufacture of S-allyl O-pentyl dithiocarbonate. Therefore, Carbon disulphide (CAS number 75–15–0) need to be considered in the assessment of S-allyl O-pentyl dithiocarbonate.
Analytical monitoring:
no
Vehicle:
no
Test organisms (species):
rat
Details on test organisms:
TEST ORGANISMS:
Rattus norvegicus (Norway Rat). The adult(s) (age: 60-90 d and organism characteristics of: LONG-EVANS)
Study type:
laboratory study
Limit test:
no
Total exposure duration:
30 d
Test temperature:
10-20 0C
Temperature was continuously recorded
Photoperiod and lighting:
They were held at a photoperiod of 14:10 light:dark.
Details on test conditions:
30 Daily for X days application of Carbon disulfide (CAS # 75150) in Corn oil carrier through a(n) intraperitoneal exposure route. The reported chemical concentrations are the result of unmeasured analysis of chemical solutions
Nominal and measured concentrations:
/DOSES/200 mg/kg//


Reference substance (positive control):
no
Duration:
30 d
Dose descriptor:
other: NOEL
Effect conc.:
200 mg/kg bw
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
growth
Duration:
30 d
Dose descriptor:
NOEC
Effect conc.:
4 000 mg/kg diet
Nominal / measured:
nominal
Conc. based on:
test mat.
Remarks:
TheNOELs can be converted to NOECs with the following two formulae:   NOECrat=NOELrat.CONVrat   Conversion factors from NOEL to NOEC for mammalian species Rattus norvegicus (> 6 weeks) is 20 (bw/dfi)  
Basis for effect:
growth
Remarks on result:
other: NOECrat=200 x 20=4000 mg/kg/diet Conversion factors from NOEL to NOEC for mammalian species Rattus norvegus >6 weeks is 20 (bw/dfi) bw = body weight (g); dfi: daily food intake (g/day)  
Details on results:
The NOEL for the  Rattus norvegicus  was 200 mg/kg bw for growth.
For the assessment of secondary poisoning, the results always have to be expressed as the concentration in food in order to be able to compare it to the PEC.

TheNOELs can be converted to NOECs with the following two formulae:
 
NOECrat=NOELrat.CONVrat
 
Conversion factors from NOEL to NOEC for mammalian species Rattus norvegicus (> 6 weeks) is 20 (bw/dfi)
 
bw = body weight (g); dfi: daily food intake (g/day)
 
NOECrat=200 x 20=4000 mg/kg/diet

A study of NC-NC Not Coded duration using not reported media was conducted in a LAB site location with Not Coded obtained Rattus norvegicus (Norway Rat). The adult(s) (age: 60-90 d and organism characteristics of: LONG-EVANS) were exposed for a duration of 30 day(s) to a(n) 30 Daily for X days application of Carbon disulfide (CAS # 75150) in Corn oil carrier through a(n) intraperitoneal exposure route. The reported chemical concentrations are the result ofunmeasured analysis of chemical solutions and are based on the NR ion. (Reference 97752, Herr,D.W., W.K. Boyes, and R.S. Dyer, 1992, Test Number 444859).

Validity criteria fulfilled:
yes
Conclusions:
The NOEL for the  Rattus norvegicus  was 200 mg/kg bw for growth.
For the assessment of secondary poisoning, the results always have to be expressed as the concentration in food in order to be able to compare it to the PEC.

TheNOELs can be converted to NOECs with the following two formulae:
 
NOECrat=NOELrat.CONVrat
 
Conversion factors from NOEL to NOEC for mammalian species Rattus norvegicus (> 6 weeks) is 20 (bw/dfi)
 
bw = body weight (g); dfi: daily food intake (g/day)
 
NOECrat=200 x 20=4000 mg/kg/diet
Executive summary:

The NOEL for the  Rattus norvegicus  was 200 mg/kg bw for growth.

For the assessment of secondary poisoning, the results always have to be expressed as the concentration in food in order to be able to compare it to the PEC.

The NOELs can be converted to NOECs with the following two formulae:

  NOECrat=NOELrat.CONVrat  

Conversion factors from NOEL to NOEC for mammalian species Rattus norvegicus (> 6 weeks) is 20 (bw/dfi)   bw = body weight (g); dfi: daily food intake (g/day)  

NOECrat=200 x 20=4000 mg/kg/diet

Endpoint:
toxicity to other above-ground organisms
Data waiving:
other justification
Justification for data waiving:
other:

Description of key information

For the assessment of secondary poisoning, the results always have to be expressed as the concentration in food in order to be able to compare it to the PEC.

TheNOELs can be converted to NOECs with the following two formulae:

 

 

NOECrat=NOELrat.CONVrat

 

Conversion factors from NOEL to NOEC for mammalian species Rattus norvegicus (> 6 weeks) is 20 (bw/dfi)

 

bw = body weight (g); dfi: daily food intake (g/day)

 

NOECrat=200x 20=4000 mg/kg/diet

Key value for chemical safety assessment

Short-term EC50 or LC50 for mammals:
20 750 mg/kg food
Long-term EC10, LC10 or NOEC for mammals:
4 000 mg/kg food

Additional information