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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Kirk-Othmer Encyclopedia of Chemical Technology are commonly accepted as trustworthy and useful reference books in REACh endpoint specific guidance.

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
Oral toxicity of xanthates
Author:
Kirk-Othmer Encyclopaedia of Chemical Technology
Year:
1984
Bibliographic source:
Vol 24, 2nd ed, pp 645-661, John Wiley & Sons, 1984.
Reference Type:
review article or handbook
Title:
Priority existing chemical Report No. 5
Author:
Dep. of Health and Ageing, Australian Government
Year:
1995
Bibliographic source:
National Industrial Chemicals Notification and Assessment Scheme

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
no
Test type:
acute toxic class method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
Wistar
Sex:
male
Details on test animals and environmental conditions:
TEST ANIMALS

- Weight at study initiation: 200-265g

- Fasting period before study: Over night

- Water: ad libitum

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Doses:
500, 590, 765, 1000, 1290, 1700, 2000 mg
No. of animals per sex per dose:
10male
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days

- Frequency of observations and weighing: Regular intervals on the day of dosing and daily thereafter for 14 days.

- Necropsy of survivors performed: yes

- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: Gross necropsies were performed on all survivors and any animals which died during the observation period. Body weights of survivors were recorded prior to sacrifice.


Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
590 mg/kg bw
Based on:
test mat.
Remarks on result:
other: oral administration of S-allyl O-pentyl dithiocarbonate to rats produced increased motor activity, cyanosis, irritability, increased respiration and convulsions with death occurring 1 to 2 hours after administration.
Mortality:
All death occurring 1 to 2 hours after administration.
Clinical signs:
Oral administration of potassium iso amyl xanthate to rats produced increased motor activity, cyanosis, irritability, increased respiration
and convulsions with death occurring 1 to 2 hours after administration.
Body weight:
Weight gain amongst survivors was within normal limits.
Gross pathology:
Autopsy showed perivascular and pericellular oedema, multiple haemorrhages in the lungs, perivascular subarachnoid haemorrhages and acute
swelling of the cells of the cortex, subcortical ganglia and the brain stem. Fatty dystrophy of the liver and protein dystrophy of the twisted canaliculi of the kidneys were observed.
Other findings:
The findings of these studies indicate that potassium amyl xanthate produces adverse effects on the central nervous system, liver and kidneys.

Applicant's summary and conclusion

Interpretation of results:
other: moderately toxic
Remarks:
Criteria used for interpretation of results: EU
Conclusions:
The LD50 value of 590 mg/kg in rats were determined for S-allyl O-pentyl dithiocarbonate. This show that S-allyl O-pentyl dithiocarbonate is of a moderately to slightly order of acute oral toxicity .
Oral administration of S-allyl O-pentyl dithiocarbonate to rats produced increased motor activity, cyanosis, irritability, increased respiration and convulsions with death occurring 1 to 2 hours after administration.