S-allyl O-pentyl dithiocarbonate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

Kirk-Othmer Encyclopedia of Chemical Technology are commonly accepted as trustworthy and useful reference books in REACh endpoint specific guidance.

Data source

Reference

Reference 1

Reference Type:

review article or handbook

Title:

Oral toxicity of xanthates

Author:

Kirk-Othmer Encyclopaedia of Chemical Technology

Year:

1984

Bibliographic source:

Vol 24, 2nd ed, pp 645-661, John Wiley & Sons, 1984.

Reference 2

Reference Type:

review article or handbook

Title:

Priority existing chemical Report No. 5

Author:

Dep. of Health and Ageing, Australian Government

Year:

1995

Bibliographic source:

National Industrial Chemicals Notification and Assessment Scheme

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

GLP compliance:

no

Test type:

acute toxic class method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

S-allyl O-pentyl dithiocarbonate

EC Number:

220-977-9

EC Name:

S-allyl O-pentyl dithiocarbonate

Cas Number:

2956-12-9

Molecular formula:

C9H16OS2

IUPAC Name:

(pentyloxy)(prop-2-en-1-ylsulfanyl)methanethione

Test animals

Species:

rat

Strain:

Wistar

Sex:

male

Details on test animals or test system and environmental conditions:

TEST ANIMALS

- Weight at study initiation: 200-265g

- Fasting period before study: Over night

- Water: ad libitum

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Doses:

500, 590, 765, 1000, 1290, 1700, 2000 mg

No. of animals per sex per dose:

10male

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days

- Frequency of observations and weighing: Regular intervals on the day of dosing and daily thereafter for 14 days.

- Necropsy of survivors performed: yes

- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: Gross necropsies were performed on all survivors and any animals which died during the observation period. Body weights of survivors were recorded prior to sacrifice.

Results and discussion

Effect levels

Sex:

male

Dose descriptor:

LD50

Effect level:

590 mg/kg bw

Based on:

test mat.

Remarks on result:

other: oral administration of S-allyl O-pentyl dithiocarbonate to rats produced increased motor activity, cyanosis, irritability, increased respiration and convulsions with death occurring 1 to 2 hours after administration.

Mortality:

All death occurring 1 to 2 hours after administration.

Clinical signs:

Oral administration of potassium iso amyl xanthate to rats produced increased motor activity, cyanosis, irritability, increased respiration
and convulsions with death occurring 1 to 2 hours after administration.

Body weight:

Weight gain amongst survivors was within normal limits.

Gross pathology:

Autopsy showed perivascular and pericellular oedema, multiple haemorrhages in the lungs, perivascular subarachnoid haemorrhages and acute
swelling of the cells of the cortex, subcortical ganglia and the brain stem. Fatty dystrophy of the liver and protein dystrophy of the twisted canaliculi of the kidneys were observed.

Other findings:

The findings of these studies indicate that potassium amyl xanthate produces adverse effects on the central nervous system, liver and kidneys.

Applicant's summary and conclusion

Interpretation of results:

other: moderately toxic

Remarks:

Criteria used for interpretation of results: EU

Conclusions:

The LD50 value of 590 mg/kg in rats were determined for S-allyl O-pentyl dithiocarbonate. This show that S-allyl O-pentyl dithiocarbonate is of a moderately to slightly order of acute oral toxicity .
Oral administration of S-allyl O-pentyl dithiocarbonate to rats produced increased motor activity, cyanosis, irritability, increased respiration and convulsions with death occurring 1 to 2 hours after administration.