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Short-term toxicity to fish

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Endpoint:
short-term toxicity to fish
Type of information:
other: published data
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Justification for type of information:
Potassium O-pentyl dithiocarbonate is similar to S-allyl O-pentyl dithiocarbonate . Comparable metabolism would occur.
Qualifier:
according to
Guideline:
OECD Guideline 203 (Fish, Acute Toxicity Test)
GLP compliance:
yes
Analytical monitoring:
not specified
Vehicle:
not specified
Test organisms (species):
Oncorhynchus mykiss (previous name: Salmo gairdneri)
Details on test organisms:
SPECIES #
(NAME): 4 Oncorhynchus mykiss (Rainbow Trout)
AGE: NR NR
LIFE STAGE: fingerling
COMMENT: 3.5 G, 6.0-7.0 CM,6.8 G, 8.8 CM
Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
96 h
Hardness:
118 to 125 mg/L CaCO3
Test temperature:
10 0C
pH:
7.9 to 8.2
Dissolved oxygen:
Saturated mg/l
Salinity:
SALINITY:NR
Nominal and measured concentrations:
TYPE VALUE RANGES STANDARD CONC (ug/L ) IONCIC FRACTION
F 18000 NR TO NR (18000) ug/L NR
F NR 32000 TO 56000 (32000-56000) ug/L NR
Details on test conditions:
TEST CONDITIONS
STUDY TYPE:
MEDIA: FW (Fresh water)
LOCATION: LAB (Laboratory, indoor)
CONTROL: I (insufficient control)
EXPOSURE TYPE: S ( static)
APPLICATION FREQ.: 1 X
EXPOSURE DUR.: 96 hour(s)
STAND DUR. (D): 4 day(s
TEST CONCENTRATION
CHEM ANAL. METHOD: unmeasured
UNIT OF MEASURE: ug/L micrograms per liter

TYPE VALUE RANGES STANDARD CONC (ug/L ) IONCIC FRACTION
F 18000 NR TO NR (18000) ug/L NR
F NR 32000 TO 56000 (32000-56000) ug/L NR
WATER QUALITY VALUE RANGE (UNIT)
TEMPERATURE: 10 NR TO NR C
pH: NR 7.9 TO 8.2
HARDNESS: NR 118 TO 125 mg/L CaCO3
SALINITY: NR NR TO NR
ALKALINITY: NR NR TO NR NR
CONDUCTIVITY: NR NR TO NR NR
DISSOLVED OXYGEN: SAT NR TO NR mg/l
ORGANIC CARBON (NR): NR NR TO NR NR
Reference substance (positive control):
not specified
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
18 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Remarks:
static conditions
Basis for effect:
mortality
Remarks on result:
other: Under the conditions of the present test Potassium amyl xanthate induced no mortality (static conditions) in Oncorhynchus mykiss (Rainbow Trout) below 3.6 mg/l (NOEC). One of the 96h-LC50 was 18 mg/l
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
> 32 - < 56 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Details on results:
EFFECT RESULTS
EFFECT: Mortality
TREND: NR
RESPONSE SITE:NR
% EFFECT: NR
EFFECT MEASUREMENT:Mortality

ENDPOINT
ENDPOINT: Lethal concentration to 50% of test organisms
ENDPOINT ASSIGN.: X
SIGNIFICANCE: NA
LEVEL: NA
BCF Value (F): NR ( NR to NR)

Preliminary testing of eight collectors (xanthates) and four frothers in 96-h static and 28-day flow-through bioassays using rainbow trout as the test organism show a great disparity in the toxicity of the chemicals administered in these two ways.

For the short-term tests, the relative toxicity of the compounds is expressed as an lc50 or as a range of concentration in mg l-1 in which the lc50 is expected to fall. Of the collectors tested in this way sodium ethyl and potassium amyl xanthate were the most toxic, with lc50's in the range of 30-50 mg l-1. Among the frothers, xylenol (cresylic acid) was found to be the most toxic (5.6 mg l-1 >lc50 > 3.2 mg l-1) while polypropylene glycol was least toxic (lc50 > 1000 mg l-1).

The long-term tests using potassium ethyl, sodium isopropyl, sodium ethyl, and potassium amyl xanthate indicated that in the flow-through system, the toxicity of the chemicals was in the order of 100 fold greater compared with the static bioassay results.

Validity criteria fulfilled:
yes
Conclusions:
Under the conditions of the present test Potassium amyl xanthate induced no mortality in Oncorhynchus mykiss (Rainbow Trout) below 3.6 mg/l (NOEC). One of the 96h-LC50 was 18 mg/l .
Potassium O-pentyl dithiocarbonate is similar to S-allyl O-pentyl dithiocarbonate . Comparable metabolism would occur.
Endpoint:
short-term toxicity to fish
Type of information:
other: published data
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Justification for type of information:
Potassium O-pentyl dithiocarbonate is similar to S-allyl O-pentyl dithiocarbonate . Comparable metabolism would occur.
Qualifier:
according to
Guideline:
OECD Guideline 203 (Fish, Acute Toxicity Test)
GLP compliance:
yes
Analytical monitoring:
not specified
Vehicle:
not specified
Test organisms (species):
Oncorhynchus mykiss (previous name: Salmo gairdneri)
Details on test organisms:
SPECIES #
(NAME): 4 Oncorhynchus mykiss (Rainbow Trout)
AGE: NR NR
LIFE STAGE: fingerling
COMMENT: 1-10 G
Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
96 h
Hardness:
348 mg/L CaCO3
ALKALINITY: 203 mg/L CaCO3
Test temperature:
12 0C
pH:
8.6
Dissolved oxygen:
Saturated mg/l
Salinity:
SALINITY:NR
Nominal and measured concentrations:
TYPE VALUE RANGES STANDARD CONC (ug/L) IONCIC FRACTION
F NR 70000 TO 75 000 70000 TO 75000 ug/L NR
F NR 70000 TO 80 000 70000 TO 80000 ug/L NR
Details on test conditions:
TEST CONDITIONS
STUDY TYPE:
MEDIA: FW (Fresh water)
LOCATION: LAB (Laboratory, indoor)
CONTROL: I (insufficient control)
EXPOSURE TYPE: S ( static)
APPLICATION FREQ.: 1 X
EXPOSURE DUR.: 96 hour(s)
STAND DUR. (D): 4 day(s
TEST CONCENTRATION
CHEM ANAL. METHOD: unmeasured
UNIT OF MEASURE: ug/L micrograms per liter

TYPE VALUE RANGES STANDARD CONC (ug/L) IONCIC FRACTION
F NR 70000 TO 75 000 70000 TO 75000 ug/L NR
F NR 70000 TO 80 000 70000 TO 80000 ug/L NR

WATER QUALITY VALUE RANGE (UNIT)
TEMPERATURE: 12 NR TO NR C
pH: 8.6 NR TO NR
HARDNESS: 348 NR TO NR mg/L CaCO3
SALINITY: NR NR TO NR
ALKALINITY: 203 NR TO NR mg/L CaCO3
CONDUCTIVITY: NR NR TO NR NR
DISSOLVED OXYGEN: SAT NR TO NR mg/l
ORGANIC CARBON (NR): NR NR TO NR NR
Reference substance (positive control):
no
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
> 70 - < 75 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Remarks on result:
other: Under the conditions of the present test Potassium amyl xanthate induced no mortality in Oncorhynchus mykiss (Rainbow Trout) below 14mg/l (NOEC). One of the 96h-LC50 was between 70 and 75 mg/l.
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
> 70 - < 80 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Remarks on result:
other: Under the conditions of the present test Potassium amyl xanthate induced no mortality in Oncorhynchus mykiss (Rainbow Trout) below 14mg/l (NOEC). One of the 96h-LC50 was between 70 and 80 mg/l.
Details on results:
EFFECT RESULTS
EFFECT: Mortality
TREND: NR
RESPONSE SITE:NR
% EFFECT: NR
EFFECT MEASUREMENT:Mortality

ENDPOINT
ENDPOINT: Lethal concentration to 50% of test organisms
ENDPOINT ASSIGN.: X
SIGNIFICANCE: NA
LEVEL: NA
BCF Value (F): NR ( NR to NR)
Validity criteria fulfilled:
yes
Conclusions:
Under the conditions of the present test Potassium amyl xanthate induced no mortality in Oncorhynchus mykiss (Rainbow Trout) below 14mg/l (NOEC). One of the 96h-LC50 was between 70 and 75 mg/l.
Potassium O-pentyl dithiocarbonate is similar to S-allyl O-pentyl dithiocarbonate . Comparable metabolism would occur.
Endpoint:
short-term toxicity to fish
Type of information:
other: published data
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Justification for type of information:
Potassium O-pentyl dithiocarbonate is similar to S-allyl O-pentyl dithiocarbonate . Comparable metabolism would occur.
Qualifier:
according to
Guideline:
OECD Guideline 203 (Fish, Acute Toxicity Test)
GLP compliance:
yes
Analytical monitoring:
not specified
Vehicle:
not specified
Test organisms (species):
Oncorhynchus mykiss (previous name: Salmo gairdneri)
Details on test organisms:
SPECIES #
(NAME): 4 Oncorhynchus mykiss
(Rainbow Trout)
AGE: NR NR
LIFE STAGE: not reported, unknown
COMMENT: NR
Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
96 h
Hardness:
118 to 125 mg/L CaCO3
Test temperature:
10 0C
pH:
7.9 to 8.2
Dissolved oxygen:
Saturated mg/l
Salinity:
SALINITY:NR
Nominal and measured concentrations:
TYPE VALUE RANGES STANDARD CONC (ug/L ) IONCIC FRACTION
F 56000 NR TO NR 56000 ug/L NR
Details on test conditions:
TEST CONDITIONS
STUDY TYPE:
MEDIA: FW (Fresh water)
LOCATION: LAB (Laboratory, indoor)
CONTROL: I (insufficient control)
EXPOSURE TYPE: S ( static)
APPLICATION FREQ.: 1 X
EXPOSURE DUR.: 96 hour(s),48 hour(s)
STAND DUR. (D): 4 day(s
TEST CONCENTRATION
CHEM ANAL. METHOD: unmeasured
UNIT OF MEASURE: ug/L micrograms per liter

TYPE VALUE RANGES STANDARD CONC (ug/L ) IONCIC FRACTION
F 56000 NR TO NR 56000 ug/L NR

WATER QUALITY VALUE RANGE (UNIT)
TEMPERATURE: 10 NR TO NR C
pH: NR 7.9 TO 8.2
HARDNESS: NR 118 TO 125 mg/L CaCO3
SALINITY: NR NR TO NR
ALKALINITY: NR NR TO NR NR
CONDUCTIVITY: NR NR TO NR NR
DISSOLVED OXYGEN: SAT NR TO NR mg/l
ORGANIC CARBON (NR): NR NR TO NR NR
Reference substance (positive control):
not specified
Duration:
96 h
Dose descriptor:
LC100
Effect conc.:
56 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Remarks on result:
other: Under the conditions of the present test Potassium amyl xanthate induced no mortality in Oncorhynchus mykiss (Rainbow Trout) below 5.6 mg/l (NOEC). One of the 48h-LC100 was 56 mg/l
Details on results:

ENDPOINT: Lethal concentration to 100% of test organisms
ENDPOINT ASSIGN.: X
SIGNIFICANCE: NA
LEVEL: NA
BCF Value (F): NR ( NR to NR)
BCF Value ():

Preliminary testing of eight collectors (xanthates) and four frothers in 96-h static and 28-day flow-through bioassays using rainbow trout as the test organism show a great disparity in the toxicity of the chemicals administered in these two ways.

For the short-term tests, the relative toxicity of the compounds is expressed as an lc50 or as a range of concentration in mg l-1 in which the lc50 is expected to fall. Of the collectors tested in this way sodium ethyl and potassium amyl xanthate were the most toxic, with lc50's in the range of 30-50 mg l-1. Among the frothers, xylenol (cresylic acid) was found to be the most toxic (5.6 mg l-1 >lc50 > 3.2 mg l-1) while polypropylene glycol was least toxic (lc50 > 1000 mg l-1).

The long-term tests using potassium ethyl, sodium isopropyl, sodium ethyl, and potassium amyl xanthate indicated that in the flow-through system, the toxicity of the chemicals was in the order of 100 fold greater compared with the static bioassay results.

Validity criteria fulfilled:
yes
Conclusions:
Under the conditions of the present test Potassium amyl xanthate induced no mortality in Oncorhynchus mykiss (Rainbow Trout) below 5.6 mg/l (NOEC). One of the 96h-LC100 was 56 mg/l .
Potassium O-pentyl dithiocarbonate is similar to S-allyl O-pentyl dithiocarbonate . Comparable metabolism would occur.
Executive summary:

Under the conditions of the present test Potassium amyl xanthate induced no mortality in Oncorhynchus mykiss (Rainbow Trout) below 5.6 mg/l (NOEC). One of the 96h-LC100 was 56 mg/l.

Potassium O-pentyl dithiocarbonate is similar to S-allyl O-pentyl dithiocarbonate. Comparable metabolism would occur.

Endpoint:
short-term toxicity to fish
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
QSAR prediction: US EPA accepted QSAR method for chemicals properties assessment.
Qualifier:
according to
Guideline:
other: QSAR
Principles of method if other than guideline:
EPI Suite v 4.1/ECOSARv1.00
GLP compliance:
no
Remarks:
not applicable to QSAR models
Analytical monitoring:
not specified
Vehicle:
not specified
Test organisms (species):
other: Fishes species
Details on test organisms:
no further information
Test type:
other: QSAR model
Water media type:
freshwater
Limit test:
no
Total exposure duration:
96 h
Hardness:
not applicable. QSAR model
Test temperature:
not applicable. QSAR model
pH:
not applicable. QSAR model
Dissolved oxygen:
not applicable. QSAR model
Salinity:
not applicable. QSAR model
Details on test conditions:
SMILES : O(C(=S)SCC=C)CCCCC
CHEM : Carbonic acid, dithio-, S-allyl O-pentyl ester
CAS Num: 2956-12-9
MOL FOR: C9 H16 O1 S2
MOL WT : 204.35
Log Kow: 3.329 (EPISuite Kowwin v1.68 Estimate)
Wat Sol: 59.63 (mg/L, EPISuite WSKowwin v1.43 Estimate)







Reference substance (positive control):
no
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
4.573 mg/L
Nominal / measured:
not specified
Conc. based on:
not specified
Basis for effect:
not specified
Details on results:
Using the EPIWIN ECOSAR QSAR model, a 96hr LC50 for freshwater fish of 4.573 mg/l was established.
Fish, 96-hr LC50 =4.573 mg/L (ppm)
Validity criteria fulfilled:
yes
Remarks:
US EPA accepted QSAR method for chemicals properties assessment.
Conclusions:
Using the EPIWIN ECOSAR QSAR model, a 96hr LC50 for freshwater fish of 4.573 mg/l was established.
Fish, 96-hr LC50 =4.573 mg/L (ppm)
Fish, 96-hr (SW) LC50 =6.412 mg/L (ppm)
Fish 30-day ChV =0.260 mg/L (ppm)
Fish (SW) 30-day ChV =1.168 mg/L (ppm)
 
Executive summary:

The ECOSAR QSAR model predicts that the 96hr LC50 for freshwater fish would to be 4.573 mg/l therefore the substance is moderately toxic to fishes.

Endpoint:
short-term toxicity to fish
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
QSAR prediction:US EPA accepted QSAR method for chemicals properties assessment.
Qualifier:
according to
Guideline:
other: QSAR
Principles of method if other than guideline:
EPI Suite v 4.1/ECOSARv1.00
GLP compliance:
no
Remarks:
not applicable to QSAR models
Analytical monitoring:
not specified
Vehicle:
not specified
Test organisms (species):
other: Fishes species
Details on test organisms:
no further information
Test type:
other: QSAR model
Water media type:
saltwater
Limit test:
no
Total exposure duration:
96 h
Hardness:
not applicable. QSAR model
Test temperature:
not applicable. QSAR model
pH:
not applicable. QSAR model
Dissolved oxygen:
not applicable. QSAR model
Salinity:
not applicable. QSAR model
Details on test conditions:
SMILES : O(C(=S)SCC=C)CCCCC
CHEM : Carbonic acid, dithio-, S-allyl O-pentyl ester
CAS Num: 2956-12-9
MOL FOR: C9 H16 O1 S2
MOL WT : 204.35
Log Kow: 3.329 (EPISuite Kowwin v1.68 Estimate)
Wat Sol: 59.63 (mg/L, EPISuite WSKowwin v1.43 Estimate)








Reference substance (positive control):
no
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
6.412 mg/L
Nominal / measured:
not specified
Conc. based on:
not specified
Basis for effect:
not specified
Details on results:
Using the EPIWIN ECOSAR QSAR model, a 96hr LC50 for marine water fish of 6.412 mg/l was established.
Fish, 96-hr LC50 =6.412 mg/L (ppm)
Validity criteria fulfilled:
yes
Remarks:
US EPA accepted QSAR method for chemicals properties assessment.
Conclusions:
Using the EPIWIN ECOSAR QSAR model, a 96hr LC50 for marine water fish of 6.412 mg/l was established.
Fish, 96-hr LC50 =4.573 mg/L (ppm)
Fish, 96-hr (SW) LC50 =6.412 mg/L (ppm)
Fish 30-day ChV =0.260 mg/L (ppm)
Fish (SW) 30-day ChV =1.168 mg/L (ppm)


Executive summary:

The ECOSAR QSAR model predicts that the 96hr LC50 for marine water fish would to be  6.412 mg/l therefore the substance is moderately toxic to fishes.

Endpoint:
short-term toxicity to fish
Type of information:
other: published data
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Justification for type of information:
Carbon disulphide (CAS number 75–15–0) is both reagents used in the manufacture of S-allyl O-pentyl dithiocarbonate. Therefore, Carbon disulphide (CAS number 75–15–0) need to be considered in the assessment of S-allyl O-pentyl dithiocarbonate.
Qualifier:
according to
Guideline:
OECD Guideline 203 (Fish, Acute Toxicity Test)
Deviations:
yes
Remarks:
incubation in sealed vessels due to volatility of CS2
GLP compliance:
not specified
Analytical monitoring:
no
Vehicle:
not specified
Details on test solutions:
- Stock solution were prepared fresh each day.
- Test solutions were renewed daily.
Test organisms (species):
Poecilia reticulata
Details on test organisms:
SPECIES #
(NAME): 28 Poecilia reticulata
(Guppy)
AGE: NR NR
LIFE STAGE: not reported, unknown
COMMENT: NR
Test type:
semi-static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
96 h
Hardness:
225 mg CaCO3/L
Test temperature:
20 °C
pH:
8.1
Dissolved oxygen:
Not reported
Nominal and measured concentrations:
Not reported
Details on test conditions:
Tests were carried out in sealed vessels to prevent evaporation.
The complete compostion of the test medium is given in Van Leeuwen and Maas, Environ. Pollution 37: 105-115 (1985)
Reference substance (positive control):
no
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
4 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Remarks on result:
other: 95% CL = 3.0 - 5.8 mg/L mg/L
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
10.74 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Remarks on result:
other: On a molecular weight scaled basis, the LC50 would be 10.63 mg/l. (4 x 204.35) /76.13 =10.74 mg/l
Details on results:
Under the conditions of the present test the 96-h LC50 of Carbon disulphide (CS2) was 4 mg/L.
The S-allyl O-pentyl dithiocarbonate (CAS No. 2956-12-9), the subject of this dossier) is expected to exhibit very similar toxicity to Carbon disulphide (CS2, (CAS No. 75-15-0)).Carbon disulphide (CAS number 75–15–0) is both reagents used in the manufacture of S-allyl O-pentyl dithiocarbonate. Therefore, Carbon disulphide (CAS number 75–15–0) need to be considered in the assessment of S-allyl O-pentyl dithiocarbonate. Comparable metabolism would occur.
On a molecular weight scaled basis, the LC50 would be 10.63 mg/l. (4 x 204.35) /76.13 =10.74 mg/l
Validity criteria fulfilled:
yes
Conclusions:
Under the conditions of the present test the 96-h LC50 of Carbon disulphide (CS2) was 4 mg/L.
The S-allyl O-pentyl dithiocarbonate (CAS No. 2956-12-9), the subject of this dossier) is expected to exhibit very similar toxicity to Carbon disulphide (CS2, (CAS No. 75-15-0)).Carbon disulphide (CAS number 75–15–0) is both reagents used in the manufacture of S-allyl O-pentyl dithiocarbonate. Therefore, Carbon disulphide (CAS number 75–15–0) need to be considered in the assessment of S-allyl O-pentyl dithiocarbonate. Comparable metabolism would occur.
On a molecular weight scaled basis, the LC50 would be 10.63 mg/l. (4 x 204.35) /76.13 =10.74 mg/l
Executive summary:

A semi-static test in a sealed system was carried out to determine the toxicity of CS2 to the fish Poecilia reticulata. The test fulfilled the requirements of OECD Guidline 203 but was not carried out in compliance with GLP. The 96-h LC50 of CS2 for Poecilia reticulata was 4 mg/L.

The  S-allyl O-pentyl dithiocarbonate (CAS No. 2956-12-9), the subject of this dossier) is expected to exhibit very similar toxicity to Carbon disulphide (CS2, (CAS No. 75-15-0)).Carbon disulphide (CAS number 75–15–0)  is both reagents used in the manufacture of S-allyl O-pentyl dithiocarbonate. Therefore, Carbon disulphide (CAS number 75–15–0) need to be considered in the assessment of S-allyl O-pentyl dithiocarbonate. Comparable metabolism would occur.

On a molecular weight scaled basis, the LC50 would be 10.63 mg/l.  (4 x 204.35) /76.13 =10.74 mg/l

Description of key information

The ECOSAR QSAR model predicts that the 96hr LC50 for freshwater fishwould to be 4.573 mg/l therefore the substance is moderately toxic to fishes.

The ECOSAR QSAR model predicts that the 96hr LC50 for marine water fish would to be  6.412 mg/l therefore the substance is moderately toxic to fishes.

Key value for chemical safety assessment

LC50 for freshwater fish:
4.573 mg/L
LC50 for marine water fish:
6.412 mg/L

Additional information