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Toxicity to terrestrial arthropods

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Endpoint:
toxicity to terrestrial arthropods: long-term
Data waiving:
exposure considerations
Justification for data waiving:
the study does not need to be conducted because direct and indirect exposure of the soil compartment is unlikely
other:
Endpoint:
toxicity to terrestrial arthropods: short-term
Type of information:
other: published data
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Justification for type of information:
Carbon disulphide (CAS number 75–15–0) is both reagents used in the manufacture of S-allyl O-pentyl dithiocarbonate. Therefore, Carbon disulphide (CAS number 75–15–0) need to be considered in the assessment of S-allyl O-pentyl dithiocarbonate.
Qualifier:
no guideline available
GLP compliance:
not specified
Application method:
spray
Analytical monitoring:
not specified
Vehicle:
no
Test organisms (species):
Apis mellifera
Animal group:
Hymenoptera (honeybees)
Study type:
field study
Limit test:
no
Total exposure duration:
4 h
Reference substance (positive control):
no
Duration:
1 h
Dose descriptor:
other: NOEL
Effect conc.:
75 other: ml/L
Nominal / measured:
nominal
Conc. based on:
act. ingr.
Basis for effect:
other: Chemical avoidance
Duration:
4 h
Dose descriptor:
other: NOEL
Effect conc.:
75 other: ml/L
Nominal / measured:
nominal
Conc. based on:
act. ingr.
Basis for effect:
other: Chemical avoidance
Duration:
1 h
Dose descriptor:
other: NOEL
Effect conc.:
201.3 mg/kg soil dw
Nominal / measured:
nominal
Conc. based on:
test mat.
Remarks:
S-allyl O-pentyl dithiocarbonate
Basis for effect:
other: Chemical avoidance
Remarks on result:
other: On a molecular weight scaled basis, the NOEL would be 201.3 mg/kg soil. (75 x 204.35) /76.13 =201.3 mg/kg soil

A study of NC-NC Not Coded duration using no substrate media was conducted in a FIELDN site location with Not Coded obtained Apis mellifera (Honey Bee). The organism(s) (age: NR NR and organism characteristics of: NR) were exposed for a duration of 1 hour(s) to a(n) 1 dosed x time(s) per study periodapplication of Carbon disulfide (CAS # 75150) in NR or a(n) NR positive control through a(n) hand spray exposure route. The reported chemical concentrations are the result of unmeasured analysis of chemical solutions and are based on the NR ion. (Reference 81711, Mayer,D.F., J.D. Lunden, G. Kovacs, and E.R. Miliczky, 2001, Test Number 571193)

Validity criteria fulfilled:
not specified
Conclusions:
Substance appears to have no significant adverse effect on bees
Endpoint:
toxicity to terrestrial arthropods: short-term
Type of information:
other: published data
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Justification for type of information:
Carbon disulphide (CAS number 75–15–0) is both reagents used in the manufacture of S-allyl O-pentyl dithiocarbonate. Therefore, Carbon disulphide (CAS number 75–15–0) need to be considered in the assessment of S-allyl O-pentyl dithiocarbonate.

Qualifier:
no guideline available
Principles of method if other than guideline:
The egg(s) (age: 2 d and organism characteristics of: NR) were exposed for a duration of 7 hour(s) to a(n) 1 dosed x time(s) per study period application of Carbon disulfide
GLP compliance:
not specified
Application method:
other: fumigation
Analytical monitoring:
not specified
Vehicle:
no
Test organisms (species):
other: Sitophilus oryzae (Rice Weevil)
Animal group:
Coleoptera (soil-dwelling rove beetle)
Details on test organisms:
Egg(s) of Sitophilus oryzae (Rice Weevil) (age: 2 d )
Kingdom: Animalia
Phylum: Arthropoda
Class: Insecta
Order: Coleoptera
Family: Curculionidae
Genus: Sitophilus
Species: S. oryzae
2 mm long with a long snout.
Study type:
laboratory study
Limit test:
no
Total exposure duration:
7 h
Nominal and measured concentrations:
DOSES-50 to 175 mg/L
Reference substance (positive control):
no
Duration:
7 h
Dose descriptor:
LC50
Effect conc.:
75 mg/kg soil dw
Nominal / measured:
nominal
Conc. based on:
act. ingr.
Basis for effect:
mortality
Duration:
7 h
Dose descriptor:
LC50
Effect conc.:
199.4 mg/kg soil dw
Nominal / measured:
nominal
Conc. based on:
test mat.
Remarks:
S-allyl O-pentyl dithiocarbonate
Basis for effect:
mortality
Remarks on result:
other: On a molecular weight scaled basis, the LC50 would be 201.32 mg/kg soil. (75 x 204.35) /76.13 =201.32 mg/kg soil
Details on results:
The LC50 for morality effects in Egg(s) of Sitophilus oryzae (Rice Weevil) by CS2 is 75mg/kg soil dw.
On a molecular weight scaled basis, the LC50 would be 201.32 mg/kg soil. (75 x 204.35) /76.13 =201.32 mg/kg soil

A study of NC-NC Not Coded duration using no substrate media was conducted in a LAB site location with Not Coded obtained Sitophilus oryzae (Rice Weevil). The egg(s) (age: 2 d and organism characteristics of: NR) were exposed for a duration of 7 hour(s) to a(n) 1 dosed x time(s) per study period application of Carbon disulfide (CAS # 75150) in NR or a(n) NR positive control through a(n) fumigation exposure route. The reported chemical concentrations are the result of unmeasured analysis of chemical solutions and are based on the NR ion. (Reference 98146, Mostafa,S.A.S., A.H. Kamel, A.K.M. El-Nahal, and F.M. El-Borollosy, 1972, Test Number 445269).

Validity criteria fulfilled:
not specified
Conclusions:
The LC50 for morality effects in Egg(s) of Sitophilus oryzae (Rice Weevil) by CS2 is 75mg/kg soil dw.
On a molecular weight scaled basis, the LC50 would be 201.32 mg/kg soil. (75 x 204.35) /76.13 =201.32 mg/kg soil
Endpoint:
toxicity to terrestrial arthropods: long-term
Type of information:
other: published data
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Justification for type of information:
Carbon disulphide (CAS number 75–15–0) is both reagents used in the manufacture of S-allyl O-pentyl dithiocarbonate. Therefore, Carbon disulphide (CAS number 75–15–0) need to be considered in the assessment of S-allyl O-pentyl dithiocarbonate.
Qualifier:
no guideline available
Principles of method if other than guideline:
Trogoderma granarium (Skin Beetle) age: 2-3 d were exposed for a duration of 7 day(s) to a(n) 24 hour application of Carbon disulfide
GLP compliance:
not specified
Application method:
other: fumigation
Analytical monitoring:
not specified
Vehicle:
no
Test organisms (species):
other: Trogoderma granarium (Skin Beetle)
Animal group:
Coleoptera (soil-dwelling rove beetle)
Details on test organisms:
Trogoderma granarium (Skin Beetle). The pupa(e) (age: 2-3 d
Study type:
laboratory study
Limit test:
no
Total exposure duration:
7 d
Reference substance (positive control):
no
Duration:
7 d
Dose descriptor:
LC50
Effect conc.:
6.8 mg/kg soil dw
Nominal / measured:
nominal
Conc. based on:
act. ingr.
Basis for effect:
mortality
Duration:
7 d
Dose descriptor:
LC50
Effect conc.:
18.08 mg/kg soil dw
Nominal / measured:
nominal
Conc. based on:
test mat.
Remarks:
S-allyl O-pentyl dithiocarbonate
Basis for effect:
mortality
Remarks on result:
other: On a molecular weight scaled basis, the LC50 would be 18.25 mg/kg soil dw. (6.8 x 204.35) /76.13 =18.25 mg/kg soil dw
Details on results:
The LC50 for morality effects inTrogoderma granarium (Skin Beetle) by CS2 is 6.8 mg/kg soil dw.
On a molecular weight scaled basis, the LC50 would be 18.25 mg/kg soil dw. (6.8 x 204.35) /76.13 =18.25 mg/kg soil dw

A study of NC-NC Not Coded duration using no substrate media was conducted in a LAB site location with Not Coded obtained Trogoderma granarium (Skin Beetle). The pupa(e) (age: 2-3 d and organism characteristics of: NR) were exposed for a duration of 7 day(s) to a(n) 24 hour application of Carbon disulfide (CAS # 75150) in NR or a(n) NR positive control through a(n) fumigation exposure route. The reported chemical concentrations are the result of unmeasured analysis of chemical solutions and are based on the NR ion. (Reference 98144, Punj,G.K., and A.N. Verma, 1970, Test Number 445233).

Validity criteria fulfilled:
not specified
Conclusions:
The LC50 for morality effects inTrogoderma granarium (Skin Beetle) by CS2 is 6.8 mg/kg soil dw.
On a molecular weight scaled basis, the LC50 would be 18.25 mg/kg soil dw. (6.8 x 204.35) /76.13 =18.25 mg/kg soil dw

Description of key information

The LC50 for morality effects  in Egg(s) of Sitophilus oryzae (Rice Weevil) by CS2 is 75 mg/kg soil dw.

On a molecular weight scaled basis, the LC50 would be 201.32 mg/kg soil. (75 x 204.35) /76.13 =201.32 mg/kg soil

The LC50 for morality effects  inTrogoderma granarium (Skin Beetle)  by CS2 is 6.8 mg/kg soil dw.

On a molecular weight scaled basis, the LC50 would be 18.25 mg/kg soil dw. (6.8 x 204.35) /76.13 =18.25 mg/kg soil dw

(NOEC=3.6 mg/kg soil dw).

 

Key value for chemical safety assessment

Short-term EC50 or LC50 for soil dwelling arthropods:
201.32 mg/kg soil dw
Long-term EC10, LC10 or NOEC for soil dwelling arthropods:
3.6 mg/kg soil dw

Additional information