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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation
Remarks:
other: in vivo / in vitro
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Publicly available literature without indication of guideline and GLP

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1984

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Public available literature. No guideline indicated. For details on method see materials and methods section in IUCLID5 dossier.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium hypochlorite
EC Number:
231-668-3
EC Name:
Sodium hypochlorite
Cas Number:
7681-52-9
Molecular formula:
ClO.Na
IUPAC Name:
sodium hypochlorite
Details on test material:
sodium hypochlorite

Test animals / tissue source

Species:
other: no data

Results and discussion

Any other information on results incl. tables

RESULTS AND DISCUSSION:
For sodium hypoclorite a severe ocular irritancy was reported. Highest tolerated (mM) dose was in Mouse 3T3, in Hamster CH V79, in Rabbit Cornea, in Human HepG2 and in Mouse RAW 264.7 cells.

Applicant's summary and conclusion

Interpretation of results:
irritating
Remarks:
Migrated information
Executive summary:
MATERIALS AND METHODS:
A short-term cytotoxicity assay and a supplementary colony forming assay were used for screening and range finding of toxic concentrations of test agents. Sodium hypochlorite was tested among other substances on several mammlian cell cultures of different organs and species of origin.

RESULTS AND DISCUSSION:
For sodium hypochlorite a severe ocular irritancy was reported. Highest tolerated (mM) dose was in Mouse 3T3,in Hamster CH V79, in Rabbit Cornea, in Human HepG2 and in Mouse RAW 264.7 cells.

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