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Registration Dossier
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EC number: 231-959-5 | CAS number: 7782-50-5
Toxicological information
Toxicological Summary
Currently viewing:
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.75 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 2
- Dose descriptor starting point:
- NOAEC
- Value:
- 1.5 mg/m³
- AF for dose response relationship:
- 1
- Justification:
- Human exposure
- AF for differences in duration of exposure:
- 2
- Justification:
- The animal and human studies showed that there is no substantial difference in N(L) OAECs following acute, subacute and/or chronic exposure by inhalation. This is supported by the fact that the toxic effects of chlorine are considered to be a function of its concentration in air and not the duration of exposure.
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- Human data
- AF for other interspecies differences:
- 1
- Justification:
- Human data
- AF for intraspecies differences:
- 1
- Justification:
- A study in hyper-responsive subjects showed no significant difference in sensitivity.
- AF for the quality of the whole database:
- 1
- Justification:
- All end-points covered.
- AF for remaining uncertainties:
- 1
- Justification:
- No remaining uncertainties.
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1.5 mg/m³
- Most sensitive endpoint:
- irritation (respiratory tract)
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- other: EU IOELV
- Overall assessment factor (AF):
- 1
- Modified dose descriptor starting point:
- NOAEC
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.75 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 2
- Dose descriptor:
- NOAEC
- AF for dose response relationship:
- 1
- Justification:
- Human exposure
- AF for differences in duration of exposure:
- 2
- Justification:
- The animal and human studies showed that there is no substantial difference in N(L) OAECs following acute, subacute and/or chronic exposure by inhalation. This is supported by the fact that the toxic effects of chlorine are considered to be a function of its concentration in air and not the duration of exposure.
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- Human data
- AF for other interspecies differences:
- 1
- Justification:
- Human data
- AF for intraspecies differences:
- 1
- Justification:
- A study in hyper-responsive subjects showed no significant difference in sensitivity.
- AF for the quality of the whole database:
- 1
- Justification:
- All end-points covered
- AF for remaining uncertainties:
- 1
- Justification:
- No remaining uncertainties
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1.5 mg/m³
- Most sensitive endpoint:
- irritation (respiratory tract)
DNEL related information
- DNEL derivation method:
- other: EU IOELV
- Overall assessment factor (AF):
- 1
- Dose descriptor starting point:
- NOAEC
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
Acute/short term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- other toxicological threshold
- Value:
- 0.5 % in mixture (weight basis)
- Most sensitive endpoint:
- skin irritation/corrosion
DNEL related information
- Dose descriptor:
- other: NOAEL
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
- Dose descriptor starting point:
- other: NOAEL
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- high hazard (no threshold derived)
Additional information - workers
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.75 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 2
- Dose descriptor starting point:
- NOAEC
- Value:
- 1.5 mg/m³
- AF for dose response relationship:
- 1
- Justification:
- Human exposure
- AF for differences in duration of exposure:
- 2
- Justification:
- The animal and human studies showed that there is no substantial difference in N(L) OAECs following acute, subacute and/or chronic exposure by inhalation. This is supported by the fact that the toxic effects of chlorine are considered to be a function of its concentration in air and not the duration of exposure.
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- Human data
- AF for other interspecies differences:
- 1
- Justification:
- Human data
- AF for intraspecies differences:
- 1
- Justification:
- A study in hyper-responsive subjects showed no significant difference in sensitivity.
- AF for the quality of the whole database:
- 1
- Justification:
- All end-points covered.
- AF for remaining uncertainties:
- 1
- Justification:
- No remaining uncertainties
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1.5 mg/m³
- Most sensitive endpoint:
- irritation (respiratory tract)
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- other: EU IOELV
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.75 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 2
- Dose descriptor:
- NOAEC
- Value:
- 1.5 mg/m³
- AF for dose response relationship:
- 1
- Justification:
- Human data
- AF for differences in duration of exposure:
- 2
- Justification:
- The animal and human studies showed that there is no substantial difference in N(L) OAECs following acute, subacute and/or chronic exposure by inhalation. This is supported by the fact that the toxic effects of chlorine are considered to be a function of its concentration in air and not the duration of exposure.
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- Human data
- AF for other interspecies differences:
- 1
- Justification:
- Human data
- AF for intraspecies differences:
- 1
- Justification:
- A study in hyper-responsive subjects showed no significant difference in sensitivity.
- AF for the quality of the whole database:
- 1
- Justification:
- All end-points covered
- AF for remaining uncertainties:
- 1
- Justification:
- No remaining uncertainties
Acute/short term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1.5 mg/m³
- Most sensitive endpoint:
- irritation (respiratory tract)
DNEL related information
- DNEL derivation method:
- other: EU IOELV
- Overall assessment factor (AF):
- 1
- Dose descriptor starting point:
- NOAEC
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
Acute/short term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.5 % in mixture (weight basis)
- Most sensitive endpoint:
- skin irritation/corrosion
DNEL related information
- Overall assessment factor (AF):
- 1
- Dose descriptor:
- other: NOAEL
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.25 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 200
- Modified dose descriptor starting point:
- NOAEL
Acute/short term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- high hazard (no threshold derived)
Additional information - General Population
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