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Administrative data

Workers - Hazard via inhalation route

Systemic effects

Long term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
0.75 mg/m³
Most sensitive endpoint:
repeated dose toxicity
Route of original study:
By inhalation
DNEL related information
DNEL derivation method:
ECHA REACH Guidance
Overall assessment factor (AF):
2
Dose descriptor starting point:
NOAEC
Value:
1.5 mg/m³
AF for dose response relationship:
1
Justification:
Human exposure
AF for differences in duration of exposure:
2
Justification:
The animal and human studies showed that there is no substantial difference in N(L) OAECs following acute, subacute and/or chronic exposure by inhalation. This is supported by the fact that the toxic effects of chlorine are considered to be a function of its concentration in air and not the duration of exposure.
AF for interspecies differences (allometric scaling):
1
Justification:
Human data
AF for other interspecies differences:
1
Justification:
Human data
AF for intraspecies differences:
1
Justification:
A study in hyper-responsive subjects showed no significant difference in sensitivity.
AF for the quality of the whole database:
1
Justification:
All end-points covered.
AF for remaining uncertainties:
1
Justification:
No remaining uncertainties.
Acute/short term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
1.5 mg/m³
Most sensitive endpoint:
irritation (respiratory tract)
Route of original study:
By inhalation
DNEL related information
DNEL derivation method:
other: EU IOELV
Overall assessment factor (AF):
1
Modified dose descriptor starting point:
NOAEC

Local effects

Long term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
0.75 mg/m³
Most sensitive endpoint:
repeated dose toxicity
DNEL related information
DNEL derivation method:
ECHA REACH Guidance
Overall assessment factor (AF):
2
Dose descriptor:
NOAEC
AF for dose response relationship:
1
Justification:
Human exposure
AF for differences in duration of exposure:
2
Justification:
The animal and human studies showed that there is no substantial difference in N(L) OAECs following acute, subacute and/or chronic exposure by inhalation. This is supported by the fact that the toxic effects of chlorine are considered to be a function of its concentration in air and not the duration of exposure.
AF for interspecies differences (allometric scaling):
1
Justification:
Human data
AF for other interspecies differences:
1
Justification:
Human data
AF for intraspecies differences:
1
Justification:
A study in hyper-responsive subjects showed no significant difference in sensitivity.
AF for the quality of the whole database:
1
Justification:
All end-points covered
AF for remaining uncertainties:
1
Justification:
No remaining uncertainties
Acute/short term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
1.5 mg/m³
Most sensitive endpoint:
irritation (respiratory tract)
DNEL related information
DNEL derivation method:
other: EU IOELV
Overall assessment factor (AF):
1
Dose descriptor starting point:
NOAEC

Workers - Hazard via dermal route

Systemic effects

Long term exposure
Hazard assessment conclusion:
low hazard (no threshold derived)
Acute/short term exposure
Hazard assessment conclusion:
low hazard (no threshold derived)
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
other toxicological threshold
Value:
0.5 % in mixture (weight basis)
Most sensitive endpoint:
skin irritation/corrosion
DNEL related information
Dose descriptor:
other: NOAEL
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified
DNEL related information
Dose descriptor starting point:
other: NOAEL

Workers - Hazard for the eyes

Local effects

Hazard assessment conclusion:
high hazard (no threshold derived)

Additional information - workers

General Population - Hazard via inhalation route

Systemic effects

Long term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
0.75 mg/m³
Most sensitive endpoint:
repeated dose toxicity
Route of original study:
By inhalation
DNEL related information
DNEL derivation method:
ECHA REACH Guidance
Overall assessment factor (AF):
2
Dose descriptor starting point:
NOAEC
Value:
1.5 mg/m³
AF for dose response relationship:
1
Justification:
Human exposure
AF for differences in duration of exposure:
2
Justification:
The animal and human studies showed that there is no substantial difference in N(L) OAECs following acute, subacute and/or chronic exposure by inhalation. This is supported by the fact that the toxic effects of chlorine are considered to be a function of its concentration in air and not the duration of exposure.
AF for interspecies differences (allometric scaling):
1
Justification:
Human data
AF for other interspecies differences:
1
Justification:
Human data
AF for intraspecies differences:
1
Justification:
A study in hyper-responsive subjects showed no significant difference in sensitivity.
AF for the quality of the whole database:
1
Justification:
All end-points covered.
AF for remaining uncertainties:
1
Justification:
No remaining uncertainties
Acute/short term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
1.5 mg/m³
Most sensitive endpoint:
irritation (respiratory tract)
Route of original study:
By inhalation
DNEL related information
DNEL derivation method:
other: EU IOELV

Local effects

Long term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
0.75 mg/m³
Most sensitive endpoint:
repeated dose toxicity
DNEL related information
DNEL derivation method:
ECHA REACH Guidance
Overall assessment factor (AF):
2
Dose descriptor:
NOAEC
Value:
1.5 mg/m³
AF for dose response relationship:
1
Justification:
Human data
AF for differences in duration of exposure:
2
Justification:
The animal and human studies showed that there is no substantial difference in N(L) OAECs following acute, subacute and/or chronic exposure by inhalation. This is supported by the fact that the toxic effects of chlorine are considered to be a function of its concentration in air and not the duration of exposure.
AF for interspecies differences (allometric scaling):
1
Justification:
Human data
AF for other interspecies differences:
1
Justification:
Human data
AF for intraspecies differences:
1
Justification:
A study in hyper-responsive subjects showed no significant difference in sensitivity.
AF for the quality of the whole database:
1
Justification:
All end-points covered
AF for remaining uncertainties:
1
Justification:
No remaining uncertainties
Acute/short term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
1.5 mg/m³
Most sensitive endpoint:
irritation (respiratory tract)
DNEL related information
DNEL derivation method:
other: EU IOELV
Overall assessment factor (AF):
1
Dose descriptor starting point:
NOAEC

General Population - Hazard via dermal route

Systemic effects

Long term exposure
Hazard assessment conclusion:
low hazard (no threshold derived)
Acute/short term exposure
Hazard assessment conclusion:
low hazard (no threshold derived)
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
0.5 % in mixture (weight basis)
Most sensitive endpoint:
skin irritation/corrosion
DNEL related information
Overall assessment factor (AF):
1
Dose descriptor:
other: NOAEL
Acute/short term exposure
Hazard assessment conclusion:
no hazard identified

General Population - Hazard via oral route

Systemic effects

Long term exposure
Hazard assessment conclusion:
DNEL (Derived No Effect Level)
Value:
0.25 mg/kg bw/day
Most sensitive endpoint:
repeated dose toxicity
DNEL related information
Overall assessment factor (AF):
200
Modified dose descriptor starting point:
NOAEL
Acute/short term exposure
Hazard assessment conclusion:
low hazard (no threshold derived)
DNEL related information

General Population - Hazard for the eyes

Local effects

Hazard assessment conclusion:
high hazard (no threshold derived)

Additional information - General Population

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