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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Publicly available literature without indication of guideline and GLP, only basic information available

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1918

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Public available literature. No guideline indicated. For details on method see materials and methods section in IUCLID5 dossier.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium hypochlorite
EC Number:
231-668-3
EC Name:
Sodium hypochlorite
Cas Number:
7681-52-9
Molecular formula:
ClO.Na
IUPAC Name:
sodium hypochlorite
Details on test material:
sodium hypochlorite, commercial product Dakin's hypochlorite (bleaching powder, 0.41-0.5% NaClO) and Javelle water (0.5-1.0% NaClO)

Test animals

Species:
mouse

Administration / exposure

Route of administration:
intraperitoneal

Results and discussion

Effect levels
Dose descriptor:
other: LD
Effect level:
240 - 250 mg/kg bw

Applicant's summary and conclusion

Executive summary:
MATERIALS AND METHODS:
Increasing doses of commercial NaClO products as Dakin´s hypochlorite
 (bleaching powder) were injected into mice i.p. and into guinea pigs subcutanously and i.p.
The smallest fatal dose was tested.

RESULTS AND DISCUSSION:
Dakin´s hypochlorite solution given i.p. is 2-3 times as toxic for the
 guinea pigs as for the mouse.