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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Physical & Chemical properties

Dissociation constant

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Administrative data

Link to relevant study record(s)

Referenceopen allclose all

Endpoint:
dissociation constant
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: No data available on test method.
Principles of method if other than guideline:
No data available on test method.
GLP compliance:
no
Dissociating properties:
yes
No.:
#1
pKa:
12.2
Remarks on result:
other: No data on temp.

pKa dissociation constant: 12.2.

Conclusions:
pKa dissociation constant: 12.2
Executive summary:

In a experimental study 2,6 -di-tert-butyl-4 -methylphenol (BHT) was found to have a pKa dissociation constant of 12.2.

Endpoint:
dissociation constant
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 112 (Dissociation Constants in Water)
GLP compliance:
not specified
Dissociating properties:
yes
No.:
#1
pKa:
12.07
Temp.:
37 °C
Conclusions:
The pKa of BHT at 37 º C was 12.07 determined by microelectrometric titration.
Executive summary:

The pKa of BHT was determined by microelectrometric titration in 50 % ethanol-water solution and corrected to pKa in water solution at 37 ºC. The pKa of BHT was 12.07.

Description of key information

In a study 2,6 -di-tert-butyl-4 -methylphenol (BHT) was found to have a pKa dissociation constant of 12.2.

The pKa of BHT was determined by microelectrometric titration in 50 % ethanol-water solution and corrected to pKa in water solution at 37 ºC. The pKa of BHT was 12.07.

Key value for chemical safety assessment

pKa at 20°C:
12.2

Additional information

Weight of evidence: Experimental results from published data.