Brief Profile

Diss Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
204-881-4
CAS no.:
128-37-0
Index number:
Molecular formula:
C15H24O
SMILES:
CC1=CC(=C(O)C(=C1)C(C)(C)C)C(C)(C)C
InChI:
InChI=1S/C15H24O/c1-10-8-11(14(2,3)4)13(16)12(9-10)15(5,6)7/h8-9,16H,1-7H3
Type of substance:
Mono constituent substance
Origin:
Organic
Registered compositions:
23
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Warning! According to the classification provided by companies to ECHA in REACH registrations this substance is very toxic to aquatic life with long lasting effects and is very toxic to aquatic life.

Additionally, the classification provided by companies to ECHA in CLP notifications identifies that this substance is harmful if swallowed.

Breakdown of all 6589 C&L notifications submitted to ECHA

Aquatic Chronic 1 H410
Aquatic Acute 1 H400
Acute Tox. 4 H302
Aquatic Chronic 4 H413
Not Classified
Eye Irrit. 2 H319
Skin Irrit. 2 H315
STOT SE 3 H335
STOT RE 2 H373
Acute Tox. 4 H312
Acute Tox. 4 H332
STOT SE 1 H370
Skin Sens. 1 H317
Repr. 2 H361
Carc. 2 H351
https://www.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/more.png 0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://www.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://www.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://www.echa.europa.eu/o/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

At least one notifier has indicated that an impurity or an additive present in the substance impacts the notified classification.

Properties of concern

  • ED
Under assessment as Endocrine Disrupting (ED list).

Regulatory context

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 36 active registrations under REACH, 1 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Registration dossiers submitted to ECHA for this substance have been evaluated under REACH.
Substance Evaluation:
Substance included in the Community Rolling Action Plan (CoRAP).
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Persistent Organic Pollutants Regulation (POPs)

List of substances subject to the POPs Regulation:
List of substances proposed as POPs:

Classification Labelling & Packaging (CLP)

Harmonised C&L:
Seveso Annex I:
Notified C&L:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 10 000 to < 100 000 tonnes per annum.

This substance is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is used in the following products: washing & cleaning products, lubricants and greases, plant protection products, adhesives and sealants and polishes and waxes.

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use and indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters).

This substance is used in the following activities or processes at workplace: the low energy manipulation of substances bound in materials or articles, high energy work-up of substances bound in materials or articles (e.g. hot rolling/forming, grinding, mechanical cutting, drilling or sanding), hand mixing with intimate contact only with personal protective equipment available, production of mixtures or articles by tabletting, compression, extrusion or pelletisation and open transfer and processing with minerals/metals at elevated temperature.

Release to the environment of this substance can occur from industrial use: industrial abrasion processing with low release rate (e.g. cutting of textile, cutting, machining or grinding of metal). Other release to the environment of this substance is likely to occur from: indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment), outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials), outdoor use in long-life materials with high release rate (e.g. tyres, treated wooden products, treated textile and fabric, brake pads in trucks or cars, sanding of buildings (bridges, facades) or vehicles (ships)) and indoor use in long-life materials with high release rate (e.g. release from fabrics, textiles during washing, removal of indoor paints).

This substance can be found in complex articles, with no release intended: vehicles. This substance can be found in products with material based on: plastic (e.g. food packaging and storage, toys, mobile phones), metal (e.g. cutlery, pots, toys, jewellery), paper (e.g. tissues, feminine hygiene products, nappies, books, magazines, wallpaper), wood (e.g. floors, furniture, toys), fabrics, textiles and apparel (e.g. clothing, mattress, curtains or carpets, textile toys) and leather (e.g. gloves, shoes, purses, furniture).

This substance is used in the following products: washing & cleaning products, polishes and waxes and plant protection products.

This substance is used in the following areas: printing and recorded media reproduction and building & construction work. This substance is used for the manufacture of: textile, leather or fur and furniture.

This substance is used in the following activities or processes at workplace: transfer of chemicals, roller or brushing applications, non-industrial spraying, closed processes with no likelihood of exposure and closed, continuous processes with occasional controlled exposure.

Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.

This substance is used in the following products: lubricants and greases, textile treatment products and dyes and polymers.

This substance is used in the following activities or processes at workplace: transfer of chemicals, mixing in open batch processes, closed batch processing in synthesis or formulation, transfer of substance into small containers, closed, continuous processes with occasional controlled exposure and closed processes with no likelihood of exposure.

Release to the environment of this substance can occur from industrial use: formulation of mixtures and formulation in materials.

This substance is used in the following products: washing & cleaning products, metal surface treatment products, textile treatment products and dyes, polymers and pH regulators and water treatment products.

This substance is used in the following areas: printing and recorded media reproduction. This substance is used for the manufacture of: plastic products, rubber products, pulp, paper and paper products and textile, leather or fur.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed, continuous processes with occasional controlled exposure, batch processing in synthesis or formulation with opportunity for exposure, closed processes with no likelihood of exposure, closed batch processing in synthesis or formulation and industrial spraying.

Release to the environment of this substance can occur from industrial use: in processing aids at industrial sites and in the production of articles.

This substance is used in the following activities or processes at workplace: closed processes with no likelihood of exposure, transfer of chemicals, closed batch processing in synthesis or formulation, closed, continuous processes with occasional controlled exposure, batch processing in synthesis or formulation with opportunity for exposure and laboratory work.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance.

ECHA has no data from registration dossiers on the precautionary measures for using this substance. Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • 3M Belgium BVBA/SPRL (OR1), Hermeslaan 7 1831 Diegem Belgium
  • Afton Chemical S.R.L. (Woluwe), Alma Court Lenneke Marelaan, 8 B-1932 St-Stevens-Woluwe Belgium
  • BASF SE, Carl-Bosch-Str. 38 67056 Ludwigshafen am Rhein Rheinland-Pfalz Germany
  • BorsodChem Zrt. - OR, Bolyai ter 1. H-3700 Kazincbarcika Hungary
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED(SINOPEC Lubricant Co., Ltd, East China Branch), Room 002, Regus Harcourt Centre D02 HW77 D02 Dublin Ireland
  • Chemservice S.A. (4T8L), 13, Fausermillen 6689 Mertert Luxembourg
  • Chevron Oronite SA - OR - CVX Oronite Cy LLC, Le Corosa 1, rue Eugène et Armand Peugeot CS10022 92508 Rueil-Malmaison Cedex France
  • Chevron Oronite SA M/I, Le Corosa 1, rue Eugène et Armand Peugeot CS10022 92508 Rueil-Malmaison Cedex France
  • CS Regulatory Ireland Ltd. in its legal capacity as Only Representative of LANXESS Corporation, Alexandra House The Sweepstakes D04 C7H2 Dublin Ballsbridge Ireland
  • DOW BENELUX B.V. - OR2, Postbus 48 4530 AA Terneuzen Netherlands
  • ExxonMobil Petroleum & Chemical BV, Polderdijkweg 2030 Antwerpen Belgium
  • Henkel Global Supply Chain B.V., Gustav Mahlerlaan 2970 1081 LA Amsterdam Netherlands
  • HH Compliance Ltd., Rubicon-Building, CIT-Campus Bishopstown none Cork Cork Ireland
  • Innochem NV, B. Adriaensenlaan 66 2450 Meerhout Belgium
  • Katyon Technologies Limited, 20 Kyriacou Matsi avenue 1082 Nicosia Cyprus
  • Labcorp Development SA 046, Parque Empresarial Las Tablas, Edificio 1 Calle Federico Mompou, 5 – 5 Planta 28050 Madrid Spain
  • Labcorp Development SA 060, Parque Empresarial Las Tablas, Edificio 1 Calle Federico Mompou, 5-5 Planta 28050 Madrid Spain
  • Lanxess Deutschland GmbH, Kennedyplatz 1 50569 Köln Germany
  • MHM Holding GmbH, Sonnenallee 1 D-85551 Kirchheim Germany
  • NHU Performance Materials GmbH, Daimlerstr. 14-16 21357 Bardowick Germany
  • Oxiris Chemicals S.A., Ctra C-35 Km59 Pol Ind Nord-est 08470 Sant Celoni Spain
  • Polymer Solutions Ibérica, S.L.U., Valle de Tamón - Nubledo Att: Javier Francos 33469 Tamón – Carreño Asturias Spain
  • PPG Europe B.V. - OR1, Amsterdamseweg 14 1422 AD Uithoorn Netherlands
  • REACHLaw Ltd., Vänrikinkuja 3 JK 21 02600 Espoo Finland
  • Rianlon GmbH, Charlottenstr. 75 40210 Duesseldorf Germany
  • Rotam Crop Protection Europe SAS, 75 cours Albert Thomas-6e avenue/Batiment D 69003 Lyon France
  • SCAS Europe S.A./N.V., Leonardo Da Vincilaan 19 B-1831 Diegem Belgium
  • SI Group France (FRAA), SAS, 2 Chemin du Trou Bieuet 60840 Catenoy 60 France
  • SI Group Germany (DEAB) GmbH, Teplitzer Strasse 14-16 84478 Waldkraiburg Germany
  • SIGMA-ALDRICH CHEMIE GMBH, Riedstrasse 2 89555 Steinheim Germany
  • Specialty Electronic Materials Netherlands BV OR-1, Baanhoekweg 22 3313 LA Dordrecht Netherlands
  • Sun Chemical B.V., Leeuwenveldseweg 3-t 1382 LV Weesp Netherlands
  • TODINI AND CO. SPA, Corso Milano 46 B 20900 MONZA ITALIA Italy
  • [Confidential], [Confidential]
  • Regartis s.r.o., Rubeška 393/7 19000 Praha 9 Czech Republic
  • Sasol Chemie GmbH & Co. KG, Anckelmannsplatz 1 20537 Hamburg Germany

Substance names and other identifiers

2,6-Di-tert-butyl-4-methylphenol
Cosmetic Products Regulation, Annex III - Restricted Substances, Food Contact Regenerated Cellulose Directive - Authorised Substances
2,6-di-tert-butyl-p-cresol
EC Inventory, REACH pre-registration, FCM and Articles Regulation, Annex I - Authorised Substances, FCMs Recycled Plastic & Articles Regulation - Annex I - Authorised Use, Recycled Plastic FCMs - Regulation (EU) 2022/1616
2,6-di-tert-butyl-p-cresol
Substance Evaluation - CoRAP, REACH pre-registration, FCM and Articles Regulation, Annex I - Authorised Substances, FCMs Recycled Plastic & Articles Regulation - Annex I - Authorised Use, Recycled Plastic FCMs - Regulation (EU) 2022/1616
Butylated hydroxytoluene
Other
- 2,6-ditert-butyl-4-methylphenol
C&L Inventory
2,6 di-tert-butyl-p-cresol
C&L Inventory
2,6-(Di-t-butyl)-p-cresol
C&L Inventory
2,6-BIS(1,1-DIMETHYLETHYL)-4-METHYLPHENOL
C&L Inventory, Registration dossier
2,6-Bis-tert-butyl-4-methylphenol
C&L Inventory
2,6-di(1,1-dimethylethyl)-4-methylphenol
C&L Inventory
2,6-Di(tert-butyl)-4-methylphenol
C&L Inventory
2,6-di-t-Butyl-p-cresol
C&L Inventory
2,6-Di-tert-buthyl-4-methyphenol
C&L Inventory
2,6-di-tert-butil-para-cresol
C&L Inventory
2,6-Di-tert-butyl-4-hydroxytoluene
C&L Inventory
2,6-Di-tert-butyl-4-methyl-1-hydroxybenzene
C&L Inventory
2,6-Di-tert-butyl-4-methylphenol
C&L Inventory, Registration dossier, Other
2,6-di-tert-butyl-4-methylphenol;
C&L Inventory
2,6-DI-TERT-BUTYL-P-CRESOL
C&L Inventory, Registration dossier
2,6-Di-tert-butyl-p-cresol
C&L Inventory, Registration dossier
2,6-DI-TERT-BUTYL-P-CRESOL(30435)
C&L Inventory
2,6-di-tert-butyl-p-cresol; BHT
Registration dossier
2,6-di-tert-butyl-p-crezol
C&L Inventory
2,6-Di-tert-butyl-p-kresol
C&L Inventory
2,6-di-tert-butyl-p-krezol
C&L Inventory
2,6-Di-tert-butyl-pkresol
C&L Inventory
2,6-di-tert-buytl-p-cresol
Registration dossier
2,6-di-tert.-butyl-4-methylphenol
C&L Inventory
2,6-di-terz-butil-4-metilfenolo
C&L Inventory
2,6-ditert-butyl-4-methylphenol
C&L Inventory, Registration dossier, Other
2,6-ditert-butyl-4-methylphenol.
C&L Inventory
4-methyl-2,6-di-(terc) butylfenol
C&L Inventory
4-methyl-2,6-di-tert-butyl-phenol
C&L Inventory
[BHT] 2,6-Di-tert-butyl-p-kresol
C&L Inventory
BHT
C&L Inventory, Registration dossier
Butil-hidroxi-toluol
C&L Inventory
Butylated Hydroxy Toluene
C&L Inventory
Butylated Hydroxytoluene
C&L Inventory
butylated hydroxytoluene, BHT
Registration dossier
Butylhydroxytoluol (BHT)
C&L Inventory
Phenol, 2,6-bis(1,1-dimethylethyl)-4-methyl
C&L Inventory
Phenol, 2,6-bis(1,1-dimethylethyl)-4-methyl-
C&L Inventory
PHENOL,2,6-BIS(1,1-DIMETHYLETHYL)-4-METHYL-
C&L Inventory
2,6-DI-TERT-BUTYL-4-METHYLPHENOL
Registration dossier
2,6-DI-TERT-BUTYL-P-CRESOL
C&L Inventory, Registration dossier
4-HYDROXY-3,5-DI-TERT-BUTYLTOLUENE
Registration dossier
4-methyl-2,6-di-tert-butylphenol antioxidant premix (BHT) of technical grade
Registration dossier
Agidol 1
Registration dossier
BHT
C&L Inventory, Registration dossier
BHT of technical grade antioxidant premix, of A and B types
Registration dossier
BUTYLATED HYDROXY TOLUENE
Registration dossier
BUTYLATED HYDROXYTOLUENE
Registration dossier
P-CRESOL, 2,6-DI-TERT-BUTYL-
Registration dossier
PHENOL, 2,6-BIS(1,1-DIMETHYLETHYL)-4-METHYL-
Registration dossier
Technical grade (BHT)
Registration dossier
102962-45-8
CAS number
Other
128-37-0
CAS number
EC Inventory, C&L Inventory, Substance Evaluation - CoRAP, Registration dossier, REACH pre-registration, Other, Cosmetic Products Regulation, Annex III - Restricted Substances, FCM and Articles Regulation, Annex I - Authorised Substances, FCMs Recycled Plastic & Articles Regulation - Annex I - Authorised Use, Recycled Plastic FCMs - Regulation (EU) 2022/1616, Food Contact Regenerated Cellulose Directive - Authorised Substances
1394965-02-6
CAS number
Other
1456709-94-6
CAS number
Other
2055662-96-7
CAS number
Other
259752-53-9
CAS number
Other
290348-23-1
CAS number
Other
338986-13-3
CAS number
Other
36631-28-4
CAS number
Other
42615-30-5
CAS number
Other
50356-19-9
CAS number
Other
50641-99-1
CAS number
Other
52683-46-2
CAS number
Other
53571-70-3
CAS number
Other
58500-82-6
CAS number
Other
83047-16-9
CAS number
Other
97123-41-6
CAS number
Other

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 5 studies submitted
  • 4 studies processed
C Physical state at 20°C and 1013 hPa
Solid (100%) [4]
C Form
Crystalline (50%), Solid: crystalline (25%), Powder (25%) [4]
C Odour
Odourless (100%) [1]
C Substance type
Organic (100%) [4]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence 3
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Physical state at 20°C and 1013 hPa
Solid (100%)

Melting/freezing point

Study results
  • 11 studies submitted
  • 4 studies processed
R Melting / freezing point
69.8 - 83.01 °C [4]

Type of Study provided
Studies with data
Key study 1
Supporting study 5
Weight of evidence 4 1
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Melting / freezing point at 101 325 Pa
83.01 °C

Boiling point

Study results
  • 9 studies submitted
  • 7 studies processed
R Boiling point
265 - 296.49 °C @ 101.3 kPa [7]

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence 7 1
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Boiling point at 101 325 Pa
265 °C

Density

Study results
  • 6 studies submitted
  • 2 studies processed
R Density
1.03 - 1.05 g/cm³ @ 20 °C [2]

Type of Study provided
Studies with data
Key study 1
Supporting study 3
Weight of evidence 2
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Relative density at 20°C
1.048

Vapour pressure

Study results
  • 9 studies submitted
  • 1 study processed
R Vapour pressure
1.1 Pa @ 20 °C [1]

Type of Study provided
Studies with data
Key study 2
Supporting study 4 1
Weight of evidence
Other 2
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Vapour pressure
0.39 Pa @ 24.85 °C

Partition coefficient

Study results
  • 13 studies submitted
  • 3 studies processed
R Pow
14 700 @ 37 °C [1]
R Log Pow
4.17 - 5.1 @ 37 °C [3]

Type of Study provided
Studies with data
Key study 1
Supporting study 1 6
Weight of evidence 2 1
Other 2
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Log Kow (Log Pow)
5.2

Water solubility

Study results
  • 12 studies submitted
  • 5 studies processed
R Water solubility (mass/vol.)
400 - 5 748 µg/L @ 20 - 30 °C and pH 6.5 [5]

Type of Study provided
Studies with data
Key study 1
Supporting study 4
Weight of evidence 4 1 1
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Water solubility
600 µg/L @ 25 °C

Solubility in organic solvents / fat solubility

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 2
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Surface tension

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Flash point

Study results
  • 5 studies submitted
  • 2 studies processed
R Flash point
127 °C @ 101.3 kPa [2]

Type of Study provided
Studies with data
Key study
Supporting study 2
Weight of evidence 2
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
R Summaries
  • 1 summary submitted
  • 1 summary processed
Flash point at 101 325 Pa
127 °C

Auto flammability

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Flammability

Study results
  • 8 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 7
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Flammability
Non flammable (100%)

Explosiveness

Study results
  • 5 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 2
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Oxidising
Non oxidising (100%)

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 4 studies submitted
  • 3 studies processed
C Dissociating properties
Yes (100%) [3]
R Dissociation constant
12.07 - 12.8 @ 25 - 37 °C [3]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence 2
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
pKa at 20 °C
12.2

Viscosity

Study results
  • 3 studies submitted
  • 2 studies processed
R Other:
0.92 - 3.47 [5]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 2
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 3 studies submitted
  • 1 study processed
R Dissipation half life (DT50)
21.054 h [1]

Type of Study provided
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Hydrolysis

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in water

Study results
  • 2 studies submitted
  • 1 study processed
R Dissipation Half-life (DT50)
4 - 8 days [1]

Type of Study provided
Studies with data
Key study 1 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 8 studies submitted
  • 2 studies processed
C Interpretation of results
Not inherently biodegradable (50%), Not readily biodegradable (50%) [2]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 5 1
Other 2
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Biodegradation in water
Under test conditions no biodegradation observed (100%)

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half-life in freshwater
8.6 days @ 12 °C

Biodegradation in soil

Study results
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 2
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half-life in soil
14.4 h @ 12 °C

Bioaccumulation: aquatic / sediment

Study results
  • 12 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 4 8
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Bioaccumulation Factor (BCF) - dimensionless
1 277

Bioaccumulation: terrestrial

Data not provided by the registrant

Adsorption/desorption

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Koc at 20°C
23 030

Henrys law constant (H)

Study results
  • 3 studies submitted
  • 1 study processed
R H - (pressure) m³/mol
318.9 Pa m³/mol @ 25 °C [1]

Type of Study provided
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Distribution modelling

Study results
  • 3 studies submitted
  • 3 studies processed
% Distribution in Media:
R Air 0.37 - 84.2 % [3]
R Water 0.75 - 10.7 % [3]
R Soil 7.47 - 82.9 % [3]
R Sediment 7.23 - 30.4 % [3]
R Suspended sediment 0.049 % [1]
R Biota 0.005 % [1]

Type of Study provided
Studies with data
Key study 3
Supporting study
Weight of evidence
Other
Data waiving
no waivers

No summary exists for this scientific endpoint

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 1 summary submitted
  • 1 summary processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 199 ng/L (1)
Intermittent releases (freshwater) 1.99 µg/L (1)
Marine water 19.9 ng/L (1)
Intermittent releases (marine water) -
Sewage treatment plant (STP) 17 µg/L (1)
Sediment (freshwater) 458.19 µg/kg sediment dw (1)
Sediment (marine water) 45.82 µg/kg sediment dw (1)
Hazard for Air
Air No hazard identified (1)
Hazard for Terrestrial Organism
Soil 53.9 µg/kg soil dw (1)
Hazard for Predators
Secondary poisoning 16.67 mg/kg food (1)

Short–term toxicity to fish

Study results
  • 11 studies submitted
  • 2 studies processed
P/RResults
LC50 (4 days) 199 - 570 µg/L [2]
LC0 (4 days) 570 µg/L [1]

Type of Study provided
Studies with data
Key study 1 1
Supporting study 2
Weight of evidence
Other 2 5
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to fish

Study results
  • 3 studies submitted
  • 2 studies processed
P/RResults
NOEC (42 days) 53 µg/L [1]
NOEC (30 days) 53 µg/L [1]
LOEC (42 days) 140 µg/L [1]
LOEC (30 days) 140 µg/L [1]

Type of Study provided
Studies with data
Key study 3
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Short–term toxicity to aquatic invertebrates

Study results
  • 7 studies submitted
  • 2 studies processed
P/RResults
EC50 (48 h) 480 - 610 µg/L [3]
NOEC (48 h) 150 - 230 µg/L [3]

Type of Study provided
Studies with data
Key study 2
Supporting study 3
Weight of evidence
Other 1 1
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Study results
  • 4 studies submitted
  • 2 studies processed
P/RResults
NOEC (21 days) 23 - 316 µg/L [3]
LOEC (21 days) 1 mg/L [1]
EC50 (21 days) 0 - 390 000 ng/L [4]

Type of Study provided
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic algae and cyanobacteria

Study results
  • 6 studies submitted
  • 4 studies processed
P/RResults
EC50 (4 days) 758 µg/L [1]
EC50 (72 h) 240 - 10 000 µg/L [5]
NOEC (72 h) 240 - 1 700 µg/L [3]
EC10 (72 h) 400 µg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence 2 1
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC10 or NOEC for freshwater algae
240 µg/L

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 10 studies submitted
  • 3 studies processed
P/RResults
EC50 (36 h) 50 mg/L [1]
EC50 (24 h) 1.7 mg/L [1]
EC50 (12 h) 25 mg/L [1]
EC50 (3 h) 10 g/L [1]
NOEC (36 h) 50 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 5
Weight of evidence 3
Other 1
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
EC50 for microorganisms
1.7 mg/L

Sediment toxicity

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Endocrine disrupter testing in aquatic vertebrates – in vivo

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No summary exists for this scientific endpoint

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 2 studies submitted
  • 2 studies processed
P/RResults
NOEC (56 days) 25 mg/kg soil dw [2]
NOEC (28 days) 100 mg/kg soil dw [4]
LOEC (56 days) 50 mg/kg soil dw [1]
LOEC (28 days) 100 mg/kg soil dw [2]
EC50 (56 days) 87.9 mg/kg soil dw [2]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Short-term EC50 / LC50
87.9 mg/kg soil dw

Toxicity to terrestrial arthropods

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial plants

Study results
  • 5 studies submitted
  • 2 studies processed
P/RResults
NOEC (17 days) 4.74 mg/kg soil dw [1]
NOEC (16 days) 4.74 mg/kg soil dw [1]
LOEC (16 days) 20.9 mg/kg soil dw [1]
EC50 (17 days) 20.9 mg/kg soil dw [1]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other 3
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Short-term EC50 / LC50
20.9 mg/kg soil dw

Toxicity to soil microorganisms

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to birds

Study results
  • 4 studies submitted
  • 1 study processed
P/RResults
NOEL (35 days) 268.1 mg/kg bw/day [1]

Type of Study provided
Studies with data
Key study 2
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 1 summary submitted
  • 1 summary processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 1.76 mg/m³ repeated dose toxicity
Acute /short term: Hazard unknown (no further information necessary as no exposure expected)
Local Effects
Long-term: Hazard unknown (no further information necessary as no exposure expected)
Acute /short term: Hazard unknown (no further information necessary as no exposure expected)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 500 µg/kg bw/day repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
EYE Exposure
No hazard identified
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 435 µg/m³ repeated dose toxicity
Acute /short term: Hazard unknown (no further information necessary as no exposure expected)
Local Effects
Long-term: Hazard unknown (no further information necessary as no exposure expected)
Acute /short term: Hazard unknown (no further information necessary as no exposure expected)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 250 µg/kg bw/day repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 250 µg/kg bw/day repeated dose toxicity
Acute /short term: No hazard identified
EYE Exposure
No hazard identified

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 51 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study
Supporting study 3
Weight of evidence 24 2
Other 17 5
Data waiving
no waivers
Study data: dermal absorption
  • 8 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study 3
Weight of evidence
Other 5
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Acute toxicity

Study results
oral
  • 28 studies submitted
  • 2 studies processed
P/RResults
LD50 2 930 - 6 000 mg/kg bw (rat) [2]
M/CInterpretations of results
GHS criteria not met [1]

Type of Study provided
oral
Studies with data
Key study 2
Supporting study 3
Weight of evidence
Other 23
Data waiving
no waivers
inhalation
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

inhalation
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
dermal
  • 3 studies submitted
  • 2 studies processed
P/RResults
LD50 2 000 mg/kg bw (rat) [2]
M/CInterpretations of results
Other [1]

dermal
Studies with data
Key study 2
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
other routes
  • 7 studies submitted
  • 0 studies processed

No automatically processable data submitted

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other 6 1
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route:
No adverse effect observed LD50 6 000 mg/kg bw
Dermal route:
No adverse effect observed LD50 2 000 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 8 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 2
Supporting study
Weight of evidence
Other 4
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Study data: eye
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 2
Supporting study
Weight of evidence
Other 1
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin
No adverse effect observed (not irritating)
Eye
No adverse effect observed (not irritating)
Respiratory
No study available

Sensitisation

Study results
Study data: skin
  • 53 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study 6
Weight of evidence 12 1
Other 30 1
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin sensitisation
No adverse effect observed (not sensitising)
Respiratory sensitisation
No study available

Repeated dose toxicity

Study results
Study data: oral
  • 67 studies submitted
  • 17 studies processed
P/RResults
NOAEL (rat): 25 - 70 mg/kg bw/day [6]
NOAEL (monkey): 50 mg/kg bw/day [1]
NOAEL (pig): 61 mg/kg bw/day [1]
NOAEL (other:): 300 mg/kg bw/day [1]
NOAEL (other:): 1 500 ppm [2]

Type of Study provided
Study data: oral
Studies with data
Key study 4
Supporting study 5
Weight of evidence 16
Other 41
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: inhalation
  • 0 studies submitted
  • 0 studies processed

No data available

Study data: inhalation
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Study data: dermal
Studies with data
Key study
Supporting study 1
Weight of evidence
Other 3
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route - systemic effects:
Adverse effect observed NOAEL 25 mg/kg bw/day (chronic, rat)

Genetic toxicity

Study results
Study data: in vitro
  • 93 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 3
Supporting study 14
Weight of evidence 22
Other 37 17
Data waiving
no waivers
Study data: in vivo
  • 37 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 2
Supporting study 6
Weight of evidence 11
Other 17 1
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Toxicity - InVitro
No adverse effect observed (negative)
Toxicity - InVivo
No adverse effect observed (negative)

Carcinogenicity

Study results
  • 59 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study 11
Weight of evidence 10 1
Other 35 1
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to reproduction

Study results
Study data: reproduction
  • 28 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 1
Supporting study 8 4
Weight of evidence 5
Other 10
Data waiving
no waivers
Study data: developmental
  • 59 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 3
Supporting study 18
Weight of evidence 3 1
Other 34
Data waiving
no waivers
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Effect on developmental toxicity
Oral route:
Adverse effect observed NOAEL 25 mg/kg bw/day (chronic, rat)

Neurotoxicity

Data not provided by the registrant

Immunotoxicity

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant