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Physical & Chemical properties

Solubility in organic solvents / fat solubility

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Endpoint:
solubility in organic solvents / fat solubility
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Remarks:
No guideline was followed and no GLP. However, it provides some scientific valid information for the weight of evidence analysis.
Principles of method if other than guideline:
Solubilites of BHT were determined either by a radiotracer technique for low concentrations or by visually observing the dissolution process as the temperature of a mixture is changed.
GLP compliance:
not specified
Key result
Medium:
other: n-heptane
Solubility:
55.9 other: wt %
Temp.:
29.5 °C
Key result
Medium:
ethanol
Solubility:
34 other: wt %
Temp.:
28.7 °C
Key result
Medium:
n-octanol
Solubility:
31.1 other: wt %
Temp.:
29.5 °C
Test substance stable:
not determined
Conclusions:
The solubility of BHT in various solvents was measured as follows:
Solubility of BHT in n-heptane at 29.5 ºC is 55.9 wt%
Solubility of BHT in ethanol at 28.7 ºC is 34 wt%
Solubility of BHT in 1-octanol at 29.5 ºC is 31.1 wt%
Executive summary:

The solubility of BHT in various solvents was measured as follows:

Solubility of BHT in n-heptane at 29.5 ºC is 55.9 wt%

Solubility of BHT in ethanol at 28.7 ºC is 34 wt%

Solubility of BHT in 1-octanol at 29.5 ºC is 31.1 wt%

Endpoint:
solubility in organic solvents / fat solubility
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
Peer reviewed data.
Principles of method if other than guideline:
No data provided on the test method.
GLP compliance:
not specified

Freely soluble in toluene; soluble in methanol, isopropanol, methyl ethyl ketone, acetone, cellosolve, benzene, most hydrocarbon solvents, ethanol, petroleum ether, liquid petrolatum (white oil): 0.5% w/w; more soluble in food oils and fats than butylated hydroxyanisol; good solubility in linseed oil.

Conclusions:
Freely soluble in toluene; soluble in methanol, isopropanol, methyl ethyl ketone, acetone, cellosolve, benzene, most hydrocarbon solvents, ethanol, petroleum ether, liquid petrolatum (white oil): 0.5% w/w; more soluble in food oils and fats than butylated hydroxyanisol; good solubility in linseed oil.
Executive summary:

Freely soluble in toluene; soluble in methanol, isopropanol, methyl ethyl ketone, acetone, cellosolve, benzene, most hydrocarbon solvents, ethanol, petroleum ether, liquid petrolatum (white oil): 0.5% w/w; more soluble in food oils and fats than butylated hydroxyanisol; good solubility in linseed oil.

Description of key information

 Based on the data included in the handbook, BHT is freely soluble in toluene; soluble in methanol, isopropanol, methyl ethyl ketone, acetone, cellosolve, benzene, most hydrocarbon solvents, ethanol, petroleum ether, liquid petrolatum (white oil): 0.5% w/w; more soluble in food oils and fats than butylated hydroxyanisol; good solubility in linseed oil.

 

Based on the experimental results from the scientific article, the solubility of BHT in various solvents was measured as follows:

Solubility of BHT in n-heptane at 29.5 ºC is 55.9 wt%

Solubility of BHT in ethanol at 28.7 ºC is 34 wt%

Solubility of BHT in 1-octanol at 29.5 ºC is 31.1 wt%

Key value for chemical safety assessment

Additional information

Weight of evidence: Experimental results from a handbook and a scientific article.