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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: publication which does not give sufficient experimental details

Data source

Reference
Reference Type:
publication
Title:
Lung toxicity and tumor promotion by hydroxylated derivatives of 2,6-di-tert-Butyl-4methylphenol (BHT) and 2-tert-Butyl-4-methyl-6-iso-propylphenol: Correlation with Quinone methide reactivity
Author:
Kupfer, R.; Dwyer-Nield, L., D.; Malkinson, A., M.; Thompson, J., A.
Year:
2002
Bibliographic source:
Chem. Res. Toxicol., 15, 1106-1112

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
other: toxicity study, single injection (i.p.) of BHT
GLP compliance:
not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2,6-di-tert-butyl-p-cresol
EC Number:
204-881-4
EC Name:
2,6-di-tert-butyl-p-cresol
Cas Number:
128-37-0
Molecular formula:
C15H24O
IUPAC Name:
2,6-di-tert-butyl-4-methylphenol
Details on test material:
no data

Test animals

Species:
mouse
Strain:
Balb/c
Sex:
male

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
corn oil
Doses:
0, 100, 150, 200 mg/kg
and 200 mg/kg
No. of animals per sex per dose:
5 per group
Control animals:
yes

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
other: maximum tolerated dose, single i.p. injection
Effect level:
200 mg/kg bw

Any other information on results incl. tables

100 mg/kg BHT had no significant effect on the lung weight: body weight ratio, but 200 mg/kg was effective

Histologic analysis of lungs: BHT produced compensatory type 2 cell hyperplasia and macrophage infiltration

Applicant's summary and conclusion

Executive summary:

MTD (i.p.): 200 mg/kg bw (Kupfer, 2002).