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EC number: 204-881-4 | CAS number: 128-37-0
The aim of the study was to evaluate the residues of Butylated hydroxytoluene (BHT) in lactating dairy cows’ milk when administered with Total Mixed Ration (TMR) at the maximum authorized dose of test product.
The study was carried out with 8 Italian Friesian dairy cows. The total study duration was 24 days as sum of 14 days of pre-experimental period for animals’ adaptation to the calan gate system and 10 consecutive days of Butylated hydroxytoluene (BHT) administration. The animals were reared into the same pen for the entire study period. The TMR was given individually with calan gate system. The test product was provided to all the 8 animals at the nominal level of 150 mg BHT/kg of complete feed based on a dry matter content of 88 % equivalent to 90.8 mg BHT/kg TMR assuming a dry matter content of 53.28 %. The data recorded during each of the 10 days of BHT administration for each animal were: live weight, milk production and feed intake. Milk composition (protein, fat, lactose, urea, somatic cells count and BHT content) was however determined at D0, D8, D9 and D10 from the beginning of the study.
The TMR provided to the animals at D0 had an analytical dry matter content of 52.49 %. Consequently, the actual level of inclusion of BHT (pre-diluted in one component of the TMR) during each of the 10 days of the study and to each animals was 89.5 mg BHT/kg of TMR. The daily analysis of the TMR (pool of the TMR sampled to each of the 8 animals) during the 10 days of the study showed a mean intake of 88.3 ± 4.9 mg BHT / kg of TMR, corresponding to 99 % of the intended level.
The physiological individual variability of the performance of the animals (live weight, milk production and feed intake) and of the milk quality (milk composition and milk component output) didn’t affect the milk residual content of BHT: the analysis of each milk samples collected at each milking from all animals during the last three days of the administration period (D1-D10) didn’t show residual content of BHT. Indeed, BHT residues were not detectable (< 0.005 mg/kg) in all cases.
In conclusion, the Butylated hydroxytoluene (BHT), when provided to lactating dairy cows with Total Mixed Ration at the maximum authorized dosage level (150 mg BHT/kg of complete feed based on a dry matter content of 88 %, therefore equivalent to 89.5 mg BHT/kg of TMR considering a dry matter content of 52.49 %) for 10 consecutive days, did not determine the occurrence of detectable residues in milk considering a LOD of 0.005 mg/kg.
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