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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Direct observations: clinical cases, poisoning incidents and other

Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
other: case report
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: case report, publication does not give sufficient details

Data source

Reference
Reference Type:
publication
Title:
Toxicity of butylated hydroxytoluene
Author:
Shlian, D., M.; et al.
Year:
1986
Bibliographic source:
The New England Journal of Medicine, vol. 314, 648-649

Materials and methods

Study type:
clinical case study
Endpoint addressed:
acute toxicity: oral
Principles of method if other than guideline:
other: case study
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
2,6-di-tert-butyl-p-cresol
EC Number:
204-881-4
EC Name:
2,6-di-tert-butyl-p-cresol
Cas Number:
128-37-0
Molecular formula:
C15H24O
IUPAC Name:
2,6-di-tert-butyl-4-methylphenol
Details on test material:
no data

Method

Subjects:
22-year old white woman
Route of exposure:
oral
Reason of exposure:
intentional
Exposure assessment:
estimated

Results and discussion

Clinical signs:
case report

Any other information on results incl. tables

Case of gastritis caused by ingestion of BHT; a 22 -year old white woman ingested 4 g BHT on an empty stomach. Later that evening, she experienced severe epigastric cramping, generalized weakness, nausea and vomiting, followed by dizziness, confusion and a brief loss of consicousness. She was admitted in a dehydrated condition with epigastric burning pain. On admission, the patient's blood pressure was 110/70 mm Hg, with moderate orthostatic changes. The stool guaiac test was negative. She was afebrile, white-cell count of 7400, a normal differential cell count and a hematocrit of 35.8. The results of liver function test, electrolyte measurement, electrocardiography, and electroencephalography were within normal limits. Treatment included hydration, prochlorperazine, and antacids; the symptoms were resolved within a few days.

Applicant's summary and conclusion