Registration Dossier
Registration Dossier
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EC number: 204-881-4 | CAS number: 128-37-0
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Internationally accepted method, ECOSAR, EPA (USA)
- Principles of method if other than guideline:
- QSAR calculation by ECOSAR v1.00a, EPA, USA (attached QSAR Prediction Reporting Format, QPRF)
- GLP compliance:
- no
- Key result
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- 0.758 mg/L
- Remarks on result:
- other: The estimated 96-h EC50 for green algae is 0.758 mg/l (ECOSAR v1.00a, phenols class).
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- The estimated 96-h EC50 for green algae is 0.758 mg/l (ECOSAR v1.00a, phenols class).
- Executive summary:
The estimated 96-h EC50 for green algae is 0.758 mg/l (ECOSAR v1.00a, phenols class).
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 2007
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Remarks:
- The tests was conducted based on OECD-GLP standards and OECD test guidelines.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Freshwater Alga and Cyanobacteria, Growth Inhibition Test)
- Deviations:
- not specified
- GLP compliance:
- yes
- Analytical monitoring:
- not specified
- Vehicle:
- not specified
- Test organisms (species):
- Raphidocelis subcapitata (previous names: Pseudokirchneriella subcapitata, Selenastrum capricornutum)
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 72 h
- Reference substance (positive control):
- not specified
- Key result
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 0.24 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- not specified
- Basis for effect:
- growth rate
- Key result
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.24 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- not specified
- Basis for effect:
- growth rate
- Validity criteria fulfilled:
- not specified
- Conclusions:
- Based on growth rate, the 72h-EC50 of the test subtance BHT in Pseudokirchneriella subcapitata was > 0.24 mg/L and the 72h-NOEC was 0.24 mg/L.
- Executive summary:
A growth inhibition test was conducted with the test subtance BHT in Pseudokirchneriella subcapitata according to OECD GLP standards and OECD guideline 201 by the Ministry of the Envinronment in Japan. Based on growth rate, the 72hour-EC50 of the test subtance BHT in Pseudokirchneriella subcapitata was > 0.24 mg/L and the 72hour-NOEC was 0.24 mg/L.
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1999
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Remarks:
- The tests was conducted based on OECD-GLP standards and OECD test guidelines. However, the Ministry of the Environment of Japan suggest confirmation of the results since the test was conducted in 1999 and some of the tests conducted before 2002 were performed using a dispersant.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Alga, Growth Inhibition Test)
- Deviations:
- not specified
- GLP compliance:
- yes
- Analytical monitoring:
- not specified
- Vehicle:
- not specified
- Test organisms (species):
- Raphidocelis subcapitata (previous names: Pseudokirchneriella subcapitata, Selenastrum capricornutum)
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 72 h
- Reference substance (positive control):
- not specified
- Key result
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 7 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Key result
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 1.7 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 10 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- test mat.
- Basis for effect:
- other: AUG
- Remarks:
- Area under growth curve
- Duration:
- 72 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 1 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- test mat.
- Basis for effect:
- other: AUG
- Remarks:
- Area under growth curve
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The 72h-EC50 for the test subtance BHT in Pseudokirchneriella subcapitata was >7.0 mg/L and the 72h-NOEC was 1.7 mg/L based on growth rate, based on area under growth curve (AUG) the 72hour-EC50 was >10 mg/L and the 72hour-NOEC was 1.0 mg/L
- Executive summary:
A growth inhibition test was conducted with the test subtance BHT in Pseudokirchneriella subcapitata according to OECD GLP standards and OECD guideline 201 by the Ministry of the Envinronment in Japan. The 72h-EC50 for the test subtance BHT in Pseudokirchneriella subcapitata was >7.0 mg/L and the 72h-NOEC was 1.7 mg/L based on growth rate, based on area under growth curve (AUG) the 72hour-EC50 was >10 mg/L and the 72hour-NOEC was 1.0 mg/L
Referenceopen allclose all
Description of key information
Estimated data: The estimated 96 -h ECC50 for green algae is 0.758 mg/L (ECOSAR V1.00a. phenol class).
Experimentla results: The 72h-EC50 for the test subtance BHT in Pseudokirchneriella subcapitata was >7.0 mg/L and the 72h-NOEC was 1.7 mg/L based on growth rate.
Experimental results: Based on growth rate, the 72h-EC50 of the test subtance BHT in Pseudokirchneriella subcapitata was > 0.24 mg/L and the 72h-NOEC was 0.24 mg/L.
Key value for chemical safety assessment
- EC10 or NOEC for freshwater algae:
- 0.24 mg/L
Additional information
Weight of evidence
Estimated data: The estimated 96 -h EC50 for green algae is 0.758 mg/L (ECOSAR V1.00a. phenol class).
Experimental results: The 72h-EC50 for the test subtance BHT in Pseudokirchneriella subcapitata was >7.0 mg/L and the 72h-NOEC was 1.7 mg/L based on growth rate.
Experimental results: Based on growth rate, the 72h-EC50 of the test subtance BHT in Pseudokirchneriella subcapitata was > 0.24 mg/L and the 72h-NOEC was 0.24 mg/L.
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