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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Dermal absorption

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Administrative data

Endpoint:
dermal absorption in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
other: review
Rationale for reliability incl. deficiencies:
other: review

Data source

Referenceopen allclose all

Reference Type:
other: MAK review, 2012
Title:
Toxikologisch-arbeitsmedizinische Begründung von MAK-Werten: Butylhydroxytoluol (BHT), Nachtrag 2012
Author:
Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe der Deutschen Forschungsgemeinschaft
Year:
2012
Bibliographic source:
Wiley-VCH Verlag GmbH & Co. KGaA, ISSN 0930-1984
Reference Type:
other: MAK review, 2004
Title:
Toxikologisch-arbeitsmedizinische Begründung von MAK-Werten: Butylhydroxytoluol (BHT), Nachtrag 2004
Author:
Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe der Deutschen Forschungsgemeinschaft
Year:
2004
Bibliographic source:
Wiley-VCH Verlag GmbH & Co. KGaA, ISSN 0930-1984
Reference Type:
publication
Title:
Topical Pharmacokinetics of [14C] butylated hydroxytoluene in the guinea pig
Author:
Courtheoux, S., I.; et al.
Year:
1985
Bibliographic source:
Dermatology, 6, 153-164
Reference Type:
publication
Title:
Percutaneous absorption of 14C-butylated hydroxytoluene and 14-C malathion in the guinea pig: effect of repeated skin administration
Author:
Marty, J., P.; et al.
Year:
1984
Bibliographic source:
Biopharm. Pharmacokinet., Eur. Congr., 2nd, vol. 1, 272-281

Materials and methods

Principles of method if other than guideline:
other: pharmacokinetic study, dermal
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
2,6-di-tert-butyl-p-cresol
EC Number:
204-881-4
EC Name:
2,6-di-tert-butyl-p-cresol
Cas Number:
128-37-0
Molecular formula:
C15H24O
IUPAC Name:
2,6-di-tert-butyl-4-methylphenol
Radiolabelling:
yes

Test animals

Species:
guinea pig
Strain:
other: Dunkin Hartley and tricolor guinea pigs

Results and discussion

Percutaneous absorption
Dose:
in vitro
Parameter:
percentage
Absorption:
13.4 %
Remarks on result:
other: 24 h
Remarks:
Based on the above mentioned data MAK concluded that overall the dermal absorption rats is 13.4%. 2.3% is resobed in the in vitro rat skin test and 11.1% is retained in the skin, and might be theoretically available for absorption (MAK 2012). This value i
Conversion factor human vs. animal skin:
MAK concluded that overall the dermal absorption rats is 13.4%. 2.3% is resorbed in the in vitro rat skin test and 11.1% is retained in the skin, and might be theoretically available for absorption (MAK 2012).

Any other information on results incl. tables

After a single application of 5 mg 14C-labelled BHT in acetone to guinea pigs (1.66 mg BHT/cm2), 9.1% of the applied dose was detected in the urine and 5% in the faeces after 7 days. Total absorption was 8.5% after 8 days using the lipophilic solvent Labrafil instead of acetone. After 3 wk of daily dermal application of 5 mg BHT in Labrafil solution (1.66 mg/cm2) and three applications of 5 mg radioactiely labelled BHT on test days 1, 8, and 15, a total absorption of up to 9.1% was determined.

Applicant's summary and conclusion