2,6-di-tert-butyl-p-cresol

Dermal absorption

Administrative data

Endpoint:

dermal absorption in vivo

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

other: review

Rationale for reliability incl. deficiencies:

other: review

Data source

Reference

Reference 1

Reference Type:

other: MAK review, 2012

Title:

Toxikologisch-arbeitsmedizinische Begründung von MAK-Werten: Butylhydroxytoluol (BHT), Nachtrag 2012

Author:

Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe der Deutschen Forschungsgemeinschaft

Year:

2012

Bibliographic source:

Wiley-VCH Verlag GmbH & Co. KGaA, ISSN 0930-1984

Reference 2

Reference Type:

other: MAK review, 2004

Title:

Toxikologisch-arbeitsmedizinische Begründung von MAK-Werten: Butylhydroxytoluol (BHT), Nachtrag 2004

Author:

Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe der Deutschen Forschungsgemeinschaft

Year:

2004

Bibliographic source:

Wiley-VCH Verlag GmbH & Co. KGaA, ISSN 0930-1984

Reference 3

Reference Type:

publication

Title:

Topical Pharmacokinetics of [14C] butylated hydroxytoluene in the guinea pig

Author:

Courtheoux, S., I.; et al.

Year:

1985

Bibliographic source:

Dermatology, 6, 153-164

Reference 4

Reference Type:

publication

Title:

Percutaneous absorption of 14C-butylated hydroxytoluene and 14-C malathion in the guinea pig: effect of repeated skin administration

Author:

Marty, J., P.; et al.

Year:

1984

Bibliographic source:

Biopharm. Pharmacokinet., Eur. Congr., 2nd, vol. 1, 272-281

Materials and methods

Principles of method if other than guideline:

other: pharmacokinetic study, dermal

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

2,6-di-tert-butyl-p-cresol

EC Number:

204-881-4

EC Name:

2,6-di-tert-butyl-p-cresol

Cas Number:

128-37-0

Molecular formula:

C15H24O

IUPAC Name:

2,6-di-tert-butyl-4-methylphenol

Radiolabelling:

yes

Test animals

Species:

guinea pig

Strain:

other: Dunkin Hartley and tricolor guinea pigs

Results and discussion

Percutaneous absorption

Dose:

in vitro

Parameter:

percentage

Absorption:

13.4 %

Remarks on result:

other: 24 h

Remarks:

Based on the above mentioned data MAK concluded that overall the dermal absorption rats is 13.4%. 2.3% is resobed in the in vitro rat skin test and 11.1% is retained in the skin, and might be theoretically available for absorption (MAK 2012). This value i

Conversion factor human vs. animal skin:

MAK concluded that overall the dermal absorption rats is 13.4%. 2.3% is resorbed in the in vitro rat skin test and 11.1% is retained in the skin, and might be theoretically available for absorption (MAK 2012).

Any other information on results incl. tables

After a single application of 5 mg ^14C-labelled BHT in acetone to guinea pigs (1.66 mg BHT/cm²), 9.1% of the applied dose was detected in the urine and 5% in the faeces after 7 days. Total absorption was 8.5% after 8 days using the lipophilic solvent Labrafil instead of acetone. After 3 wk of daily dermal application of 5 mg BHT in Labrafil solution (1.66 mg/cm2) and three applications of 5 mg radioactiely labelled BHT on test days 1, 8, and 15, a total absorption of up to 9.1% was determined.