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EC number: 204-881-4 | CAS number: 128-37-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- other: review
- Rationale for reliability incl. deficiencies:
- other: review
Data source
Referenceopen allclose all
- Reference Type:
- other: MAK review, 2012
- Title:
- Toxikologisch-arbeitsmedizinische Begründung von MAK-Werten: Butylhydroxytoluol (BHT), Nachtrag 2012
- Author:
- Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe der Deutschen Forschungsgemeinschaft
- Year:
- 2 012
- Bibliographic source:
- Wiley-VCH Verlag GmbH & Co. KGaA, ISSN 0930-1984
- Reference Type:
- other: MAK review, 2004
- Title:
- Toxikologisch-arbeitsmedizinische Begründung von MAK-Werten: Butylhydroxytoluol (BHT), Nachtrag 2004
- Author:
- Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe der Deutschen Forschungsgemeinschaft
- Year:
- 2 004
- Bibliographic source:
- Wiley-VCH Verlag GmbH & Co. KGaA, ISSN 0930-1984
- Reference Type:
- publication
- Title:
- Topical Pharmacokinetics of [14C] butylated hydroxytoluene in the guinea pig
- Author:
- Courtheoux, S., I.; et al.
- Year:
- 1 985
- Bibliographic source:
- Dermatology, 6, 153-164
- Reference Type:
- publication
- Title:
- Percutaneous absorption of 14C-butylated hydroxytoluene and 14-C malathion in the guinea pig: effect of repeated skin administration
- Author:
- Marty, J., P.; et al.
- Year:
- 1 984
- Bibliographic source:
- Biopharm. Pharmacokinet., Eur. Congr., 2nd, vol. 1, 272-281
Materials and methods
- Principles of method if other than guideline:
- other: pharmacokinetic study, dermal
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2,6-di-tert-butyl-p-cresol
- EC Number:
- 204-881-4
- EC Name:
- 2,6-di-tert-butyl-p-cresol
- Cas Number:
- 128-37-0
- Molecular formula:
- C15H24O
- IUPAC Name:
- 2,6-di-tert-butyl-4-methylphenol
Constituent 1
- Radiolabelling:
- yes
Test animals
- Species:
- guinea pig
- Strain:
- other: Dunkin Hartley and tricolor guinea pigs
Results and discussion
Percutaneous absorption
- Dose:
- in vitro
- Parameter:
- percentage
- Absorption:
- 13.4 %
- Remarks on result:
- other: 24 h
- Remarks:
- Based on the above mentioned data MAK concluded that overall the dermal absorption rats is 13.4%. 2.3% is resobed in the in vitro rat skin test and 11.1% is retained in the skin, and might be theoretically available for absorption (MAK 2012). This value i
- Conversion factor human vs. animal skin:
- MAK concluded that overall the dermal absorption rats is 13.4%. 2.3% is resorbed in the in vitro rat skin test and 11.1% is retained in the skin, and might be theoretically available for absorption (MAK 2012).
Any other information on results incl. tables
After a single application of 5 mg 14C-labelled BHT in acetone to guinea pigs (1.66 mg BHT/cm2), 9.1% of the applied dose was detected in the urine and 5% in the faeces after 7 days. Total absorption was 8.5% after 8 days using the lipophilic solvent Labrafil instead of acetone. After 3 wk of daily dermal application of 5 mg BHT in Labrafil solution (1.66 mg/cm2) and three applications of 5 mg radioactiely labelled BHT on test days 1, 8, and 15, a total absorption of up to 9.1% was determined.
Applicant's summary and conclusion
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