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Toxicological information

Carcinogenicity

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Description of key information

In accordance with column 2 of REACH Annex X No. 8.9.1, the study does not need to be conducted as 
- in all in vitro and in vivo genotoxitity studies performed, no evidence was found that the substance induced any mutagenic or genotoxic response and
- there was no evidence from the repeated dose studies that the substance is able to induce hyperplasia or pre-neoplastic lesions.

Key value for chemical safety assessment

Carcinogenicity: via oral route

Endpoint conclusion
Endpoint conclusion:
no study available

Carcinogenicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Carcinogenicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no study available

Justification for classification or non-classification

There is no evidence for a muutagenic or carcinogenic potential of n-Butyl Acetate. Therefore a carcinogenicity classification is not justified.

Additional information

In accordance with column 2 of REACH Annex X No. 8.9.1, the study does not need to be conducted as

- in all in vitro and in vivo genotoxitity studies performed, no evidence was found that the substance induced any mutagenic or genotoxic response and

- there was no evidence from the repeated dose studies that the substance is able to induce hyperplasia or pre-neoplastic lesions.


Justification for selection of carcinogenicity via oral route endpoint:
No carcinogenicity study is required, since the substance is not mutagenic and no hyperplasia or pre-neoplastic lesions were observed in any available studies.

Justification for selection of carcinogenicity via inhalation route endpoint:
No carcinogenicity study is required, since the substance is not mutagenic and no hyperplasia or pre-neoplastic lesions were observed in any available studies.

Justification for selection of carcinogenicity via dermal route endpoint:
No carcinogenicity study is required, since the substance is not mutagenic and no hyperplasia or pre-neoplastic lesions were observed in any available studies.