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EC number: 204-658-1 | CAS number: 123-86-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1987
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Was not conducted under GLP but has sufficient data for interpretation of results.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- yes
- Remarks:
- (too many animals per dose group; doses tested choosen too high)
- GLP compliance:
- no
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- N-butyl acetate
- EC Number:
- 204-658-1
- EC Name:
- N-butyl acetate
- Cas Number:
- 123-86-4
- Molecular formula:
- C6H12O2
- IUPAC Name:
- butyl acetate
- Details on test material:
- - Name of test material (as cited in study report): N-Butyl Acetate
- Physical state: liquid
- Analytical purity: as n-butyl acetate is usually available as high quality / purity, it can probably be assumed that test item purity was high
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 200 to 300 g
- Fasting period before study: overnight before dosing
- Diet: commercial available diet, ad libitum
- Water: municipal water, ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- males: 16.0, 11.3 & 8.0 ml/kg.
females: 16.0, 11.3, 8.0 & 4.0 ml/kg. - No. of animals per sex per dose:
- 5 rats per sex at 16.0, 11.3, 8.0 ml/kg.
2 rats (female only) at 4.0 ml/kg. - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: day 0, 7 and 14.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, gross pathology: - Statistics:
- LD50's and the estimated LD50 slopes are calculated by the moving average method (Thompson, 1947; Weil, 1983).
Results and discussion
- Preliminary study:
- none.
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 14.5 mL/kg bw
- 95% CL:
- 9.3 - 22.7
- Remarks on result:
- other: LD50 (calculated 12789 mg/kg, based on specific gravity of 0.882)
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 12.2 mL/kg bw
- 95% CL:
- 9.2 - 16.1
- Remarks on result:
- other: LD50 (calculated 10760 mg/kg, based on specific gravity of 0.882)
- Mortality:
- 16.0 ml/kg: 3 of 5 males, 4 of 5 females
11.3 ml/kg: 1 of 5 males, 2 of 5 females - Clinical signs:
- other: 16.0 ml/kg male: Sluggishness at 30 min; moribund appearance at 2 hr. Survivors recovered at 1 day. 16.0 ml/kg female: Sluggishness at 30 min to 1 hr; prostration in 2 at 1 hr; moribund appearance in 1 at 2 hr. Death of 2 at 3 hr. Survivor recovered at 1
- Gross pathology:
- 16.0 ml/kg male: In victims, ventral surface of liver of 1 pale tan; stomachs tan or red, liquid or gas-filled. In survivors, nothing
remarkable.
16.0 ml/kg female: In victims, ventral surface of livers of 2 pale tan; stomachs of 2 filled with clear liquid. In survivor, nothing remarkable.
11.3 ml/kg male: In victim, stomach tan and red, distended, gas-filled. In survivors, lungs of 2 mottled light and dark red; kidneys of 2 mottled tan and brown.
11.3 ml/kg female: In victims, ventral surface of liver of 1 pale tan; stomachs distended, gas-filled. In survivors, lungs of 2 dark red. - Other findings:
- None.
Any other information on results incl. tables
None.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- N-Butyl Acetate was slightly toxic following its administration by single peroral intubation. The acute oral LD50 for n-Butyl Acetate in male rats is 14.5 ml/kg bwt (9.3 - 22.7 ml/kg; calculated 12789 mg/kg, based on specific gravity of 0.882). The acute oral LD50 for n-Butyl Acetate in female rats is 12.2 ml/kg bwt (9.2 - 16.1; ml/kg; calculated 10760 mg/kg, based on specific gravity of 0.882 .
- Executive summary:
N-Butyl Acetate was tested for acute oral toxicity in 5 male rats/dose at doses of 16.0, 11.3 and 8.0 ml/kg. Male dosing killed 3 out of 5 rats at 16.0 ml/kg, 1 of 5 at 11.3 ml/kg and 0 of 5 at 8.0 ml/kg. Acute oral toxicity in 5 female rats/dose at doses of 16.0, 11.3, 8.0 and 4.0 ml/kg resulted in 4 of 5 deaths at 16.0 ml/kg, 2 of 5 at 11.3 ml/kg, 0 of 5 at 8.0 ml/kg and 0 of 2 at 4.0 ml/kg.
Based on the results obtained, the LD50 was 14.5 ml/kg for male rats (calculated 12789 mg/kg, based on specific gravity of 0.882) and 12.2 ml/kg for female rats (calculated 10760 mg/kg) under the study conditions (Myers et al., 1987).
This study was judged to be reliable (RL2) and therefore was selected as key study.
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