Registration Dossier
Registration Dossier
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EC number: 204-658-1 | CAS number: 123-86-4
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- year of publication: 1946
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Does not meet important criteria of today standard methods
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 946
- Report date:
- 1946
Materials and methods
- Type of study / information:
- eye irritation ("chemical burns of the cornea")
- Endpoint addressed:
- eye irritation
- Principles of method if other than guideline:
- case report with description of the treatment technique
- GLP compliance:
- no
Test material
- Reference substance name:
- N-butyl acetate
- EC Number:
- 204-658-1
- EC Name:
- N-butyl acetate
- Cas Number:
- 123-86-4
- Molecular formula:
- C6H12O2
- IUPAC Name:
- butyl acetate
- Details on test material:
- - Name of test material (as cited in study report): butyl acetate
Constituent 1
Method
- Ethical approval:
- not applicable
- Remarks:
- (occupational case report)
- Details on study design:
- A chemical burn of the cornea is de-fined as an injury which results from local contact with a chemical (solid, liquid, or vapor) to such a degree that there is alteration in the structure of the cornea and the conjunctiva. This alteration in structure is demonstrated by a positive stain when a 2% buffered solution of fluorescein is applied.
- Details on exposure:
- no details given
Results and discussion
- Results:
- One case of a chemical burn of the cornea was reported, which could be healed by the authors denuding technique and therefore promptly vanished within 48 hours.
Applicant's summary and conclusion
- Executive summary:
One case of a chemical burn of the cornea was reported, which could be healed within 48 hours (McLaughlin, 1946).
The study is not reliable (RL3) as it does not meet relevant criteria of today standard methods and a lot of information are missing.
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