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Toxicological information

Exposure related observations in humans: other data

Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
year of publication: 1946
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Does not meet important criteria of today standard methods

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1946
Report date:
1946

Materials and methods

Type of study / information:
eye irritation ("chemical burns of the cornea")
Endpoint addressed:
eye irritation
Principles of method if other than guideline:
case report with description of the treatment technique
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
N-butyl acetate
EC Number:
204-658-1
EC Name:
N-butyl acetate
Cas Number:
123-86-4
Molecular formula:
C6H12O2
IUPAC Name:
butyl acetate
Details on test material:
- Name of test material (as cited in study report): butyl acetate

Method

Ethical approval:
not applicable
Remarks:
(occupational case report)
Details on study design:
A chemical burn of the cornea is de-fined as an injury which results from local contact with a chemical (solid, liquid, or vapor) to such a degree that there is alteration in the structure of the cornea and the conjunctiva. This alteration in structure is demonstrated by a positive stain when a 2% buffered solution of fluorescein is applied.
Details on exposure:
no details given

Results and discussion

Results:
One case of a chemical burn of the cornea was reported, which could be healed by the authors denuding technique and therefore promptly vanished within 48 hours.

Applicant's summary and conclusion

Executive summary:

One case of a chemical burn of the cornea was reported, which could be healed within 48 hours (McLaughlin, 1946).

The study is not reliable (RL3) as it does not meet relevant criteria of today standard methods and a lot of information are missing.