Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Exposure related observations in humans: other data

Administrative data

exposure-related observations in humans: other data
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
year of publication: 1946
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Does not meet important criteria of today standard methods

Data source

Reference Type:
Report date:

Materials and methods

Type of study / information:
eye irritation ("chemical burns of the cornea")
Endpoint addressed:
eye irritation
Principles of method if other than guideline:
case report with description of the treatment technique
GLP compliance:

Test material

Constituent 1
Chemical structure
Reference substance name:
N-butyl acetate
EC Number:
EC Name:
N-butyl acetate
Cas Number:
Molecular formula:
butyl acetate
Details on test material:
- Name of test material (as cited in study report): butyl acetate


Ethical approval:
not applicable
(occupational case report)
Details on study design:
A chemical burn of the cornea is de-fined as an injury which results from local contact with a chemical (solid, liquid, or vapor) to such a degree that there is alteration in the structure of the cornea and the conjunctiva. This alteration in structure is demonstrated by a positive stain when a 2% buffered solution of fluorescein is applied.
Details on exposure:
no details given

Results and discussion

One case of a chemical burn of the cornea was reported, which could be healed by the authors denuding technique and therefore promptly vanished within 48 hours.

Applicant's summary and conclusion

Executive summary:

One case of a chemical burn of the cornea was reported, which could be healed within 48 hours (McLaughlin, 1946).

The study is not reliable (RL3) as it does not meet relevant criteria of today standard methods and a lot of information are missing.