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EC number: 204-658-1 | CAS number: 123-86-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Additional information
Short-term toxicity to fish:
Fathead minnow (P. promelas): 96-h LC50 = 18 mg/L (similar to OECD TG 203, flow-through, measured; Brooke et al., 1984)
Long-term toxicity to fish:
In accordance with column 2 of REACH Annex XI, long-term testing shall be proposed by the registrant if the chemical safety assessment according to Annex I indicates the need to investigate further the effects on aquatic organisms. The substance is not classified as dangerous to the environment according to Regulation 67/548/EEC. Chronic toxicity is not expected based on the results of ECOSAR (NOEC > 1 mg/L; ECT, 2009). Therefore and for reasons of animal welfare a long-term toxicity study with fish is not proposed.
Short-term toxicity to aquatic invertebrates:
Water flea (Daphnia sp. ): 48 -h EC50 = 44 mg/L (similar to OECD 202, static, no analytical verification of test conc.; Bringmann & Kühn, 1959)
Long-term toxicity to aquatic invertebrates:
The chronic toxicity to aquatic invertebrates was tested in a reproduction test according to OECD 211 using the supporting substance isobutyl acetate (CAS 110 -19 -0). The 21 -d NOEC was determined to be 23 mg/L, the EC50 34 mg/L (CERI, 2000). These values are confirmed by ECOSAR v1.00 (ECT, 2009). The chronic value was estimated to be 26 mg/L.
Chronic toxicity is therefore not expected.
Growth inhibition to aquatic algae:
The effect of n-butyl acetate on growth of Desmodesmus subspicatus (reported as Scenedesmus subspicatus) was investigated: 72-h NOEC: 200 mg/L, 72-h ErC50 = 648 mg/L (no analytical monitoring; Huels, 1988). In an OECD 201 study with the analogue substance iso-butyl acetate the following vaules were determined: 72-h NOEC: 196 mg/L, 72 -h ErC50 = 397 mg/L (CERI, 2000) (lowest values from three studies evaluated in a weight-of-evidence approach).
Toxicity to microorganisms:
Tetrahymena pyriformis: 40-h IGC50 = 356 mg/L (TETRATOX; Schultz, 2006)
The inhibition of the degradation activity of activated sludge is not anticipated when introduced in appropriately low concentrations.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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