Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Endpoint summary

Administrative data

Description of key information

Additional information

Short-term toxicity to fish:

Fathead minnow (P. promelas): 96-h LC50 = 18 mg/L (similar to OECD TG 203, flow-through, measured; Brooke et al., 1984)

Long-term toxicity to fish:

In accordance with column 2 of REACH Annex XI, long-term testing shall be proposed by the registrant if the chemical safety assessment according to Annex I indicates the need to investigate further the effects on aquatic organisms. The substance is not classified as dangerous to the environment according to Regulation 67/548/EEC. Chronic toxicity is not expected based on the results of ECOSAR (NOEC > 1 mg/L; ECT, 2009). Therefore and for reasons of animal welfare a long-term toxicity study with fish is not proposed.

Short-term toxicity to aquatic invertebrates:

Water flea (Daphnia sp. ): 48 -h EC50 = 44 mg/L (similar to OECD 202, static, no analytical verification of test conc.; Bringmann & Kühn, 1959)

Long-term toxicity to aquatic invertebrates:

The chronic toxicity to aquatic invertebrates was tested in a reproduction test according to OECD 211 using the supporting substance isobutyl acetate (CAS 110 -19 -0). The 21 -d NOEC was determined to be 23 mg/L, the EC50 34 mg/L (CERI, 2000). These values are confirmed by ECOSAR v1.00 (ECT, 2009). The chronic value was estimated to be 26 mg/L.

Chronic toxicity is therefore not expected.

Growth inhibition to aquatic algae:

The effect of n-butyl acetate on growth of Desmodesmus subspicatus (reported as Scenedesmus subspicatus) was investigated: 72-h NOEC: 200 mg/L, 72-h ErC50 = 648 mg/L (no analytical monitoring; Huels, 1988). In an OECD 201 study with the analogue substance iso-butyl acetate the following vaules were determined: 72-h NOEC: 196 mg/L, 72 -h ErC50 = 397 mg/L (CERI, 2000) (lowest values from three studies evaluated in a weight-of-evidence approach).

Toxicity to microorganisms:

Tetrahymena pyriformis: 40-h IGC50 = 356 mg/L (TETRATOX; Schultz, 2006)

The inhibition of the degradation activity of activated sludge is not anticipated when introduced in appropriately low concentrations.