Registration Dossier
Registration Dossier
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EC number: 204-658-1 | CAS number: 123-86-4
Endpoint summary
Administrative data
Description of key information
Additional information
Short-term toxicity to fish:
Fathead minnow (P. promelas): 96-h LC50 = 18 mg/L (similar to OECD TG 203, flow-through, measured; Brooke et al., 1984)
Long-term toxicity to fish:
In accordance with column 2 of REACH Annex XI, long-term testing shall be proposed by the registrant if the chemical safety assessment according to Annex I indicates the need to investigate further the effects on aquatic organisms. The substance is not classified as dangerous to the environment according to Regulation 67/548/EEC. Chronic toxicity is not expected based on the results of ECOSAR (NOEC > 1 mg/L; ECT, 2009). Therefore and for reasons of animal welfare a long-term toxicity study with fish is not proposed.
Short-term toxicity to aquatic invertebrates:
Water flea (Daphnia sp. ): 48 -h EC50 = 44 mg/L (similar to OECD 202, static, no analytical verification of test conc.; Bringmann & Kühn, 1959)
Long-term toxicity to aquatic invertebrates:
The chronic toxicity to aquatic invertebrates was tested in a reproduction test according to OECD 211 using the supporting substance isobutyl acetate (CAS 110 -19 -0). The 21 -d NOEC was determined to be 23 mg/L, the EC50 34 mg/L (CERI, 2000). These values are confirmed by ECOSAR v1.00 (ECT, 2009). The chronic value was estimated to be 26 mg/L.
Chronic toxicity is therefore not expected.
Growth inhibition to aquatic algae:
The effect of n-butyl acetate on growth of Desmodesmus subspicatus (reported as Scenedesmus subspicatus) was investigated: 72-h NOEC: 200 mg/L, 72-h ErC50 = 648 mg/L (no analytical monitoring; Huels, 1988). In an OECD 201 study with the analogue substance iso-butyl acetate the following vaules were determined: 72-h NOEC: 196 mg/L, 72 -h ErC50 = 397 mg/L (CERI, 2000) (lowest values from three studies evaluated in a weight-of-evidence approach).
Toxicity to microorganisms:
Tetrahymena pyriformis: 40-h IGC50 = 356 mg/L (TETRATOX; Schultz, 2006)
The inhibition of the degradation activity of activated sludge is not anticipated when introduced in appropriately low concentrations.
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