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Toxicological information

Genetic toxicity: in vitro

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Administrative data

Endpoint:
in vitro gene mutation study in bacteria
Remarks:
Type of genotoxicity: gene mutation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Original study is not availlable. Study is cited and evaluated in the EU Risk Assessment Report 2002 on 4-nonylphenol (branched) and nonylphenol as.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1984

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Ames test
GLP compliance:
no
Type of assay:
bacterial reverse mutation assay

Test material

Reference
Name:
Unnamed
Type:
Constituent

Method

Species / strain
Species / strain / cell type:
S. typhimurium, other: S. typhimurium TA 1538, TA 1537, TA 98 and TA 100
Metabolic activation:
with and without
Metabolic activation system:
Aroclor induced rat liver
Test concentrations with justification for top dose:
up to 5000 µg/plate
Controls
Untreated negative controls:
not specified
Negative solvent / vehicle controls:
not specified
True negative controls:
not specified
Positive controls:
not specified
Positive control substance:
not specified

Results and discussion

Test results
Species / strain:
other: Aroclor induced rat liver

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information):
negative

S. typhimurium TA 1535, TA 1538, TA 98 and TA 100 were exposed to nonylphenol at concentrations to 5000 µg/plate, both in the presence and absence of metabolic activator. The result was negative.