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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
acute dermal toxicity can be waived due to corrosive properties of NP. The range finding toxicity data provided by Smyth et al. are without documentation. The Dermal LD50 = 2031 mg/kg in groups of four male New Zealand white rabbits; exposure period was 24 hours

Data source

Reference
Reference Type:
publication
Title:
Range-finding toxicity data: list VII
Author:
Smyth H. F., Carpenter C. P., Weil C. S., Pozzani U., Striegel J. A. and Nycum J. S.
Year:
1969
Bibliographic source:
Am Ind Hyg Assoc J 30, 470-476

Materials and methods

Test type:
standard acute method

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Applicant's summary and conclusion