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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Endpoint summary

Administrative data

Description of key information

Additional information

The review of nonylphenol exposure to terrestrial organisms resulted in reliable toxicity test studies by eight authors for a total of eight terrestrial species of soil invertebrates, plants and soil micro-organisms. From the limited reliable data available, soil invertebrates were more sensitive to the toxic effects of nonylphenol than terrestrial plants and micro-organisms for acute, short-term exposures and the relative sensitivity between soil invertebrates and plants was an order of magnitude different (L/EC50 for earthworm survival and plant growth were 88.6 and 559 mg nonylphenol/L, respectively).


Toxicity data for long-term exposure to nonylphenol indicated the lowest Key Study NOEC or EC10value of 23 mg nonylphenol/kg soil for reproduction in the Collembolan (Folsomia fimetaria) by Scott-Fordsmand et al., 2004. The lowest Key Study NOEC or EC10for plants based on fresh weight was field mustard (Brassica rapa) of 574.8 mg nonylphenol/kg using artificial soils (Domene et al, 2009). As in short-term toxicity studies, soil invertebrates were more sensitive than plants to long-term nonylphenol exposures.

Two studies were available for avian toxicity on the Japanese quail. The key study investigated the effects from foodbourne nonylphenol. A range of different effects were observed for reproductive endpoints. The NOECs for male body weight, fertilisation rate, survival of newborn quails after 14 days, normal histopathology of male gonads were <10mg/kg diet; the NOEC for female body weight was 10mg/kg diet; the NOEC for number of eggs produced, egg shell thickness, number of broken eggs, sex ratios and normal female ovarian tissue were >50mg/kg diet; and the NOEC for hatching rate was 20 mg/kg diet (Cheng et al, 2019).