Registration Dossier
Registration Dossier
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EC number: 284-325-5 | CAS number: 84852-15-3
Endpoint summary
Administrative data
Description of key information
For fish species, Watanabe et al (2017) is the Key Study and the key value is a NOEC for fertilised eggs (fertility) in the Japanese medaka (Oryzias latipes) F0 and F1 generations of 0.00127 mg/L or 1.27µg/L. For freshwater invertebrate species, Cornement (2020) provided a 28-day EC10 (reproduction) of 0.004 mg/L nonylphenol for the mud snail species, Potamopyrgus antipodarum. For algal species, the Scholz (1989) study was selected as a key study because it provides both an EC50 (1.3 mg nonylphenol/L) and EC10 (0.5 mg nonylphenol/L) concentration for growth inhibition for a common algal test speciesDesmodesmus subspicatus. Ward and Boeri (1990) was also selected as a key study because it provides EC50 toxicity information for the preferred algal test organism Pseudokirchneriella subcapitata and of the marine algae Skeletonema costatum, although a non-standard test duration (96 hours) determining 96 h EC50s of 0.41 mg/L and 0.027 mg nonylphenol/L, respectively.
A number of additional studies have been added to the long term toxicity sections for fish, invertebrates and algae since the 2010 registration dossier submission. A chronic toxicity test on an invertebrate species remains ongoing at the time of the update in 2021; Huntsman (2020) on Crassostrea gigas. The PNEC has been updated to include new studies on P. antipodarum (freshwater) and Lytechinus pictus (saltwater) and a further update will be made when the pacific oyster (C. gigas) results are available.
Additional information
The review of nonylphenol exposure to aquatic organisms resulted in reliable toxicity tests covering freshwater and saltwater species of fish, invertebrates, algae and an amphibian. Toxicity test results indicated fish were more sensitive to the toxic effects of nonylphenol than invertebrates, algae or amphibians for acute, short-term exposures. Freshwater fish were more sensitive also when considering short-term, withthe lowest LC50 for survival for fish and invertebrates of 0.01 and 0.08 mg nonylphenol/L, respectively. Toxicity data for long-term exposure to nonylphenol indicated the lowest NOEC value of 0.00127 mg nonylphenol/L for fertilised eggs in adult and first-generation fish was similar to the EC10 of 0.004 mg nonylphenol/L for invertebrate reproduction.
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