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Physical & Chemical properties

Partition coefficient

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Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
from 2009-04-28 to 2009-05-15
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2009
Report Date:
2009

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
not specified
GLP compliance:
no
Type of method:
HPLC method
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Nonylphenol
- Substance type: pure active substance
- Physical state: no data
- Analytical purity: no data
- Lot/batch No.: 2008-01-22
- Expiration date of the lot/batch: no data
- Stability under test conditions: no data
- Storage condition of test material: no data

Study design

Analytical method:
high-performance liquid chromatography

Results and discussion

Partition coefficient
Type:
log Pow
Partition coefficient:
5.4
Temp.:
23 °C
pH:
5.7
Details on results:
see below

Any other information on results incl. tables

Calibration:

 Substances  log Pow  retention time[min]  capacity factork  log k
 Acetophenone  1.7  1.95  0.620  -0.21
 Phenyl benzoate  3.6  7.29  5.059  0.70
 Diphenyl ether  4.2  11.68  8.712  0.94
 Dibenzyl  4.8  29.78  23.757  1.38
 Fluoranthene  5.1  38.22  30.770  1.49
 Triphenylamine  5.7  72.51  59.273  1.77

Correlation log k and Pow:

Slope: 1.99

Axis intercept: 2.17

Correlation coefficient: 0.998

Measurement:

   1. Determination  2. Determination  Mean
Retention time [min]  51.33  51.39  51.4
 Peak areas  15454866  15441582  15448174
 Capacity factor k  41.67  41.72  41.7
 log k  1.62  1.62  1.6
 log Pow  5.4  5.4  5.4

Applicant's summary and conclusion

Conclusions:
The measured log Pow of Nonylphenol was determined to be 5.4 at 23 °C and a pH of 5.7.
Executive summary:

The log Pow of the test substance Nonylphenol was determined according to OECD Guideline for Testing of Chemicals No. 117 "Partition Coefficient (n-octanol/water), High Performance Liquid Chromatography (HPLC) Method", adopted 13 April 2004.

The log Pow was determined to be 5.4 at 23 °C and a pH of 5.7. As reference substances were used: Acetophenone, Phenyl benzoate, Diphenyl ether, Dibenzyl, Fluoranthene and Triphenylamine with the respective log Pow: 1.7, 3.6, 4.2, 4.8, 5.1 and 5.7. The calibration showed a correlation coefficient of 0.998.