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Description of key information

The dermal absorption of radioactive labelled Nonylphenol and two nonylphenol ethoxylates (NPE-4, NPE-9) was tested in an ex vivo isolated perfused porcine skin flap (IPPSF) assay and an in vitro porcine skin flow  through (PSFT) diffusion cell assay.

Key value for chemical safety assessment

Absorption rate - dermal (%):
1

Additional information

The dermal absorption of NP was tested in an ex vivo perfused porcine skin flap model (IPPSF). This model has earlier been shown to be a reliable tool to predict human exposure because of its intact vasculature, as well as anatomical and physiological similarities to human skin.

NP in aqueous PEG-400 solutions is absorbed at 0.1% of the applied dose after 8h, representing the amount of systemic available compound. It has been shown earlier that this rate was not significantly altered by using different vehicles (PEG-400 vs. water) or concentrations (0.1, 1.0, or 10%). The value is therefore considered to be valid also for higher concentrations.

About 0.75% of the applied dose penetrated the stratum corneum and underlying dermis within 8 h. In a worst case scenario all of the penetrated substance could subsequently be absorbed leading to an increased systemic exposure. This estimate does not account for a loss of stratum corneum due to exfoliation. However, the overall potential systemic exposure from skin contact to NP is still considerable less than 1%. This is in accordance with previous results from an in vitro porcine skin flow through (PSFT) diffusion cell assay.