Methyl methacrylate

Endpoint summary

Description of key information

LC50 fish (96h): > 100 mg/l (lepomis macrochirus)

NOEC fish (35 d): 9.4 mg/l (Danio rerio)

EC50 daphnia (48h): 69 mg/l

NOEC daphnia (21d): 37 mg/l

ErC50 algae (72h): > 110 mg/l (Pseudokircheriella supcapitata)

NOEC algae (72h): 110 mg/l (Pseudokircheriella supcapitata)

NOEC microorganisms: > 100 mg/l

Additional information

Data availability:

For MMA acute as well as chronic studies of sufficient reliability are available for all three trophic levels, as well as reliable microbial toxicity data.

Summary:

Fish:

Two flow through acute toxicity studies to fish are available with methyl methacrylate. Bowman (1990) tested oncorynchus mykiss for 96 hrs in concentrations up to 79 mg/l (meas. conc.) . No mortality was observed in this test.

A second study (Bailey et al, 1985) tested methyl methacrylate in concentrations above 100 mg/l to lepomis macrochirus. LC 50 (96 h) was evaluated with 191 mg/l (arithm. mean meas. conc.).

Based on these results LC50 fish (96h) of methyl methacrylate is > 100 mg/l.

Chronic aquatic toxicity to fish (Schäfers, 2002) of methyl methacrylate was tested in a fish early life stage test acc. OECD 210 under flow through conditions with Danio rerio at nominal test concentration of 9.38, 18.8, 37.5, 75.0, and 150 mg/L. After 35 days, the NOEC (nominal conc.) was 9.4 mg/L based on hatching, weight and length, the LOEC (hatch, weight and length) was 18.8 mg/.

LC50 and LC10 based on mortality were 33.7 mg/L and 16.9mg/L, respectively.

Daphnia magna:

In a guideline study according EPA OTS 797.1300 (Burgess, 1990), the toxicity to Daphnia magna of MMA was tested in nominal concentrations of 7.2, 14, 30, 60 and 120 mg/l (corresponding to measured concentrations calculated from analytical sampling at 0 and 48 hrs of 5.2, 11, 23, 48 and 100 mg/l). No immobilization was observed in concentrations up to 48 mg/l, 100 % immobilization occurred at 100 mg/l. EC50 Daphnia magna (48h) was calculated to be 69 mg/l.

 

The 21-day-chronic toxicity of methyl methacrylate to Daphnia magna Straus was studied under flow through conditions according to OECD guideline 211 (cited as OECD Guideline 202, part 2 (Daphnia sp., Reproduction Test). Daphnids were exposed to the test chemical at nominal test concentration of 13, 25, 50, 100 and 200 mg/L corresponding to measured concentrations of 3.9, 10, 18, 37 and 68 mg/L

The 21-d EC50 based on mortality was 49 mg/l ( corresponding 95 % confidence limit calculated by binominal probability of 37 to 68 mg).

The 21-day NOEC based on reproduction was 37 mg/l. Daphnid reproduction was not adversely affected by exposure to concentrations less than those affecting daphnid survival.

 

Algae

In a 72 hour acute toxicity study (Smyth & Long, 1999), the cultures of Pseudokircheriella subcapitata were exposed to methyl methacrylate at measured concentrations of 3.6, 9.7, 22, 49, 110 mg/L under static conditions in acc. with OECD 301 (adopted 12 December 1992). Substance loss during the test was 6 -13 %.

EC50 (72h) based on growth rate was > 110 mg/l, NOEC (72h) based on growth rate was 110 mg/l.