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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Method sufficiently described.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1937

Materials and methods

Test guideline
Qualifier:
no guideline followed
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Methyl methacrylate
EC Number:
201-297-1
EC Name:
Methyl methacrylate
Cas Number:
80-62-6
Molecular formula:
C5H8O2
IUPAC Name:
methyl methacrylate
Test material form:
liquid
Specific details on test material used for the study:
Supplier: Dupont

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
oral gavage by measn of a blunt hypodermic needle

Administration / exposure

Route of administration:
oral: gavage
Doses:
0.006; 0.007; 0.008; 0.009; 0.010; 0.011; 0.012 ml
No. of animals per sex per dose:
5; 10; 10; 10; 10; 10; 5
sex not specified
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
approximate LD50
Effect level:
ca. 8 500 - ca. 9 400 mg/kg bw
Mortality:
observed
Other findings:
Twenty to forty minutes after oral treatment all rats showed a more ar less pronounced dyspnea fom which some did not recover after twentyfour hours later, while others died within this time.

Applicant's summary and conclusion