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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Basic data given.

Data source

Reference
Reference Type:
publication
Title:
LC50 value for rats acutely exposed to methyl methacrylate monomer vapor.
Author:
Tansy MF, Landin WE, Kendall FM
Year:
1980
Bibliographic source:
J. Dent. Res. 59: 1074

Materials and methods

Principles of method if other than guideline:
Study to assess the acute inhalative toxicity of methyl methacrylate in rats after 4 h of exposure.
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Methyl methacrylate
EC Number:
201-297-1
EC Name:
Methyl methacrylate
Cas Number:
80-62-6
Molecular formula:
C5H8O2
IUPAC Name:
methyl methacrylate
Test material form:
liquid
Specific details on test material used for the study:
not specified in the publication

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Diet (e.g. ad libitum): Purina Laboratory Chow
- Water (e.g. ad libitum): tap water
- Acclimation period: at least one week

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Vehicle:
other: unchanged (no vehicle)
Details on inhalation exposure:
75 liter glass dynamic chambers were used. The generation of the test atmosphere was previously described by Tansy et al., Environ. Res., 11:66, 1976.
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
4 h
Concentrations:
0 (sham exposed), 4750, 6146, 8044, 10209, 13479 ppm (corresponding to ca. 19.5, 25.2, 33.0, 41.9 and 55.3 mg/L)
No. of animals per sex per dose:
10 (5 males, 5 females)
Control animals:
yes
Details on study design:
24 hour post-exposure observation period.
Statistics:
Interpolation of the linear regression of the log of the number of survivors against concentration of vapor. The LC50 was computed from responses of those groups where the mortality was greater than zero and less than 100%.

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LC50
Effect level:
29.8 mg/L air
Based on:
test mat.
Exp. duration:
4 h
Remarks on result:
other: corresponding to 7093 ppm
Remarks:
LC50 value coputed from responses of those groups where the mortality was greater than zero and less than 100 %
Mortality:
19.5 mg/L (4750 ppm): 8/10 animals died
25.2 mg/L (6146 ppm): 6/10 animals died
33.0 mg/L (8044 ppm): 2/10 animals died
41.9 mg/L (10209 ppm): 0/10 animals died
55.3 mg/L (13479 ppm): 0/10 animals died
Clinical signs:
other: not reported
Body weight:
not reported
Gross pathology:
not reported

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Executive summary:

Acute inhalation toxicity of methyl methacrylate was tested in Sprague Dawley rats with 4 hours whole body exposure. 5 dose groups of 10 animals each (5males, 5 females) were tested in cocentrations of 19.5 mg/l (4750 ppm) to 55.3 mg/l (13476 ppm).

LC50 acute: 29.8 mg/l ( 7093 ppm). (Result based on those dose groups where result was greater than zero and less than 100 % mortality.)