Registration Dossier

Environmental fate & pathways

Additional information on environmental fate and behaviour

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Administrative data

Endpoint:
additional information on environmental fate and behaviour
Type of information:
calculation (if not (Q)SAR)
Remarks:
Migrated phrase: estimated by calculation
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study well documented, meets generally accepted scientific principles, acceptable for assesment

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
2002
Reference Type:
publication
Title:
No information
Author:
Anon.
Year:
2002
Bibliographic source:
Commission Directive 2002/72/EC of 6 August 2002 relating to plastics materials and articles intended to come into contact with foodstuffs. Official Journal of the European Communities L 220/18
Reference Type:
study report
Title:
Unnamed
Year:
2001

Materials and methods

GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid

Results and discussion

Any other information on results incl. tables

Instance: If one assumes a one hour skin contact (assuming T = 37°C and  intimate

 contact) with 1 dm2 of a PMMA polymer of any thickness and  having 1% MMA as an 

initial concentration, then the maximum possible  migration (assuming complete 

MMA uptake through the skin) is estimated to  be approx. 4.5 µg for WP = 1 and 

14 µg for WP = 0.99 conditions. In  relation to the maximum possible migration, 

even these overexaggerating  assumptions lead to relative migrations as low as 

between 0.0004% and  0.0012% of maximum possible migration in case of a 0.1 mm 

thick PMMA  layer. For thicker layers, for lower CP,0 values and in real life 

(where  only a fraction of the total MMA uptake can occur) the relative 

migration  would be one to several orders of magnitude lower.


Applicant's summary and conclusion