Registration Dossier
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EC number: 201-297-1 | CAS number: 80-62-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- other: personal communication of worker health observations
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- Assessment of observations regarding the health of exposed workers; Particularly useful, because historical exposures tended to be at least one order of magnitude higher compared to current work practices and therefor this information is relevant to hazard assessment in humans.
Data source
Reference
- Reference Type:
- other: expert communication
- Title:
- Letter to the Chairman if the Threshold Limits Committee of ACGIH
- Author:
- Coleman AL
- Year:
- 1 963
- Bibliographic source:
- -
Materials and methods
- Type of study / information:
- Letter of the Chief Industrial Hygienist of the Occupational Health Section of the Labour Department of the State of Connecticut to the Chairman of ACGIH regarding workplace experience of MMA.
- Endpoint addressed:
- respiratory irritation
- Principles of method if other than guideline:
- Expert judgement
- GLP compliance:
- no
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Test material form:
- liquid
Results and discussion
- Results:
- The author and the members of his team noted a strong, easily detectable smell in areas with concentrations between 32 and 65 ppm, very definite irritation in areas with 170 to 248 ppm and unbearable discomfort in an area with a spot concentration of 2300 ppm. The author and his team concluded that 100 ppm could be tolerated continuously without discomfort.
Applicant's summary and conclusion
- Conclusions:
- The effects described in this letter are consistent with irritation in the respiratory tract in humans at concentrations exceeding 100 ppm.
- Executive summary:
The effects described in this letter are consistent with irritation in the respiratory tract in humans at concentrations exceeding 100 ppm.
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