Methyl methacrylate

Exposure related observations in humans: other data

Administrative data

Endpoint:

exposure-related observations in humans: other data

Type of information:

other: personal communication of worker health observations

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Remarks:

Assessment of observations regarding the health of exposed workers; Particularly useful, because historical exposures tended to be at least one order of magnitude higher compared to current work practices and therefor this information is relevant to hazard assessment in humans.

Data source

Reference

Reference Type:

other: expert communication

Title:

Letter to the Chairman if the Threshold Limits Committee of ACGIH

Author:

Coleman AL

Year:

1963

Bibliographic source:

-

Materials and methods

Type of study / information:

Letter of the Chief Industrial Hygienist of the Occupational Health Section of the Labour Department of the State of Connecticut to the Chairman of ACGIH regarding workplace experience of MMA.

Endpoint addressed:

respiratory irritation

Principles of method if other than guideline:

Expert judgement

GLP compliance:

no

Test material

Reference

Name:

Unnamed

Type:

Constituent

Test material form:

liquid

Results and discussion

Results:

The author and the members of his team noted a strong, easily detectable smell in areas with concentrations between 32 and 65 ppm, very definite irritation in areas with 170 to 248 ppm and unbearable discomfort in an area with a spot concentration of 2300 ppm. The author and his team concluded that 100 ppm could be tolerated continuously without discomfort.

Applicant's summary and conclusion

Conclusions:

The effects described in this letter are consistent with irritation in the respiratory tract in humans at concentrations exceeding 100 ppm.

Executive summary:

The effects described in this letter are consistent with irritation in the respiratory tract in humans at concentrations exceeding 100 ppm.