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EC number: 201-297-1
CAS number: 80-62-6
A two years toxicity study was performend in 1964 to study the
tolerance of animals to chronic ingestion of methyl methacrylate.
Twenty-five male and female Wistar rats were administered three
doses of methyl methacrylate in the drinking water for two years
(Borzelleca et al. 1964). Initial doses of 6, 60 or 2000 ppm were
partially raised to 7, 70 and 2000 ppm after 5 months.
A special design was employed to reduce the volatilization and
measurements which showed that the methyl methacrylate concentrations
remained within 15% of the nominal concentration for 72 hours. Body
weight depression was also observed at 2000 ppm but it did not persist
beyond the first few weeks of the study. Significant depression of fluid
consumption was observed at 2000 ppm, although this tended to regress at
the end of the study. Individual observations of depressed food
consumption tended to parallel periods of depressed growth. There were
significantly increased kidney ratios for female rats at 2000 ppm. These
effects were believed to be a consequence of reduced food intake and
reduced body weights, and in the absence of any histopathology, were
considered as not biologically relevant. Therefore the NOAEL is
considered to be >= 2000 ppm, corresponding to 90.3 mg/kg bw/day and
193.8 mg/kg bw/day, for males and females, respectively, on the basis of
treatment specific fluid consumption rates and body weights.
No relevant effects were observed after exposure of rats in
drinking water up to the highest dose tested (2000 ppm, limited by
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