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Toxicological information

Sensitisation data (human)

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Administrative data

Endpoint:
sensitisation data (humans)
Type of information:
other: exposure-related observations in humans:
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
Sensitivity to methyl methacrylate
Author:
Nyquist G.
Year:
1958
Bibliographic source:
Trans. Royal School Dent. 1: 36-51 (1958)

Materials and methods

Type of sensitisation studied:
skin
Study type:
study with volunteers
Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Study with volunteers to assess the potential for skin irritation and skin sensitisation in humans via a modified patch test.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Methyl methacrylate
EC Number:
201-297-1
EC Name:
Methyl methacrylate
Cas Number:
80-62-6
Molecular formula:
C5H8O2
IUPAC Name:
methyl methacrylate
Test material form:
liquid

Method

Type of population:
general
Ethical approval:
confirmed, but no further information available
Subjects:
Twenty female volunteers without reported previous contact to MMA
Volunteers: 20 young healthy women between 18 and 21 years of age.

Results and discussion

Any other information on results incl. tables

Eighteen of 20 volunteers responded with skin reactions varying from erythema to delayed eczematous dermatitis. A distinct differentiation between sensitisation and irritation react ions was not made by the author. In a follow-up patch test of the same subjects with small plates of heat cured acrylic resin containing 5.2% to 6.4% of residual MMA monomer no skin reactions were observed.

Applicant's summary and conclusion

Conclusions:
Eighteen of 20 volunteers responded with skin reactions varying from erythema to delayed eczematous dermatitis. A distinct differentiation between sensitisation and irritation reactions was not made by the author. In a follow-up patch test of the same subjects with small plates of heat cured acrylic resin containing 5.2% to 6.4% of residual MMA monomer no skin reactions were observed.
Although a clear distinction between sensitisation and irritation is difficult and the exposure period is far longer than usual in irritation testing the results suggest that MMA may have the potential for skin irritation in humans.
Executive summary:

Eighteen of 20 volunteers responded with skin reactions varying from erythema to delayed eczematous dermatitis. A distinct differentiation between sensitisation and irritation reactions was not made by the author. In a follow-up patch test of the same subjects with small plates of heat cured acrylic resin containing 5.2% to 6.4% of residual MMA monomer no skin reactions were observed.

Although a clear distinction between sensitisation and irritation is difficult and the exposure period is far longer than usual in irritation testing the results suggest that MMA may have the potential for skin irritation in humans.