Registration Dossier

Administrative data

Endpoint:
short-term repeated dose toxicity: other route
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
No data
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Very few details in this old study

Data source

Reference
Reference Type:
publication
Title:
The toxic effects of amines
Author:
Johnston AR
Year:
1928
Bibliographic source:
The Journal of Infectious diseases 42:473-484

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
No guideline was available when the study has been performed. The design of the study is not similar to the current guideline but the data about the effects are valid
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
No data

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
water
Analytical verification of doses or concentrations:
no
Duration of treatment / exposure:
Days 1, 2 and 7: 0.1 mL of the saturated solution
Day 12: 0.4 mL
Day 26: 1 mL
Frequency of treatment:
See above
Doses / concentrations
Remarks:
Doses / Concentrations:
see above
No. of animals per sex per dose:
1 animal
Control animals:
not specified

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

After the first injection, the animal recovered from the general anesthesia in 12 hours. Twenty four hours later the dose was repeated from which recovery occurred after 24 hours sleep. Five days later the same dose did not produce sleep. On the 12th day 0.4 cc. of the solution did not produce sleep, and on the 26th day 1.0 cc. produced deep anaesthesia until death of the animal 24 hours later.

Applicant's summary and conclusion

Conclusions:
Sublethal doses of quinoline produces anaesthesia in the rabbit and a tolerance is observed when doses are repeated.
Executive summary:

Sublethal doses of quinoline were administered to 1 rabbit by ip, general anaesthesia is observed and a tolerance is also produced when the doses are repeated.