Registration Dossier
Registration Dossier
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EC number: 202-051-6 | CAS number: 91-22-5
Repeated dose toxicity: other routes
Administrative data
- Endpoint:
- short-term repeated dose toxicity: other route
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- No data
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Very few details in this old study
Data source
Reference
- Reference Type:
- publication
- Title:
- The toxic effects of amines
- Author:
- Johnston AR
- Year:
- 1 928
- Bibliographic source:
- The Journal of Infectious diseases 42:473-484
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- No guideline was available when the study has been performed. The design of the study is not similar to the current guideline but the data about the effects are valid
- GLP compliance:
- no
Test material
- Reference substance name:
- Quinoline
- EC Number:
- 202-051-6
- EC Name:
- Quinoline
- Cas Number:
- 91-22-5
- Molecular formula:
- C9H7N
- IUPAC Name:
- quinoline
- Details on test material:
- No data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- water
- Analytical verification of doses or concentrations:
- no
- Duration of treatment / exposure:
- Days 1, 2 and 7: 0.1 mL of the saturated solution
Day 12: 0.4 mL
Day 26: 1 mL - Frequency of treatment:
- See above
Doses / concentrations
- Remarks:
- Doses / Concentrations:
see above
- No. of animals per sex per dose:
- 1 animal
- Control animals:
- not specified
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
After the first injection, the animal recovered from the general anesthesia in 12 hours. Twenty four hours later the dose was repeated from which recovery occurred after 24 hours sleep. Five days later the same dose did not produce sleep. On the 12th day 0.4 cc. of the solution did not produce sleep, and on the 26th day 1.0 cc. produced deep anaesthesia until death of the animal 24 hours later.
Applicant's summary and conclusion
- Conclusions:
- Sublethal doses of quinoline produces anaesthesia in the rabbit and a tolerance is observed when doses are repeated.
- Executive summary:
Sublethal doses of quinoline were administered to 1 rabbit by ip, general anaesthesia is observed and a tolerance is also produced when the doses are repeated.
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