Registration Dossier

Ecotoxicological information

Toxicity to other aquatic organisms

Currently viewing:

Administrative data

Endpoint:
toxicity to other aquatic vertebrates
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Study period:
no data
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Neither EU nor OECD guideline is available for test on amphibian. It is impossible to evaluate the validity of this study.

Data source

Reference
Reference Type:
publication
Title:
Toxicity and Teratogenicety of Aromatic amines to Xenopus laevis
Author:
Dumont JN, Schultz TW, Jones RD
Year:
1979
Bibliographic source:
Bull Env contam toxicol 22: 159-166

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Exposure of Xenopus embryos to different concentrations of quinoline for 96 h
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
no data

Sampling and analysis

Analytical monitoring:
no

Test solutions

Vehicle:
no

Test organisms

Test organisms (species):
Xenopus laevis

Study design

Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
96 h

Results and discussion

Effect concentrations
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
26.3 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Remarks on result:
other: 22.1-31.3 mg/L

Any other information on results incl. tables

Table 1: Lethality and teratogenic effects of quinoline

Conc. mg/L

24 h

48 h

72 h

96 h

A/S

%

A/S

%

A/S

%

A/S

%

Dead + abnormal (%)

0

0/100

0

0/96

0

2/96

2

3/96

3

7

10

0/96

0

1/95

1

3/95

3

3/95

3

8

25

3/93

3

20/91

22

30/86

35

37/86

43

51

50

6/93

6

39/87

44

49/83

59

56/83

67

73

75

6/96

6

46/86

53

63/86

72

68/86

79

82

100

12/86

14

46/63

73

60/62

97

62/62

100

100

125

14/77

18

14/14

100

0/0

 

0/0

 

0

A/S = abnormal / survivors

Applicant's summary and conclusion

Validity criteria fulfilled:
not applicable
Remarks:
no validity criteria available
Conclusions:
The LC50 (96 h) on xenopus embryos is 26.3 mg/L.
Executive summary:

An acute toxicity test of quinoline on embryos of Xenopus laevis has been determined after exposure for 96 h to different concentrations.

The teratogenic effetcs were also recorded.

The LC50 (96h) is 26.3 mg/L.