Quinoline

Toxicity to other aquatic organisms

Administrative data

Endpoint:

toxicity to other aquatic vertebrates

Type of information:

experimental study

Adequacy of study:

disregarded due to major methodological deficiencies

Study period:

no data

Reliability:

3 (not reliable)

Rationale for reliability incl. deficiencies:

other: Neither EU nor OECD guideline is available for test on amphibian. It is impossible to evaluate the validity of this study.

Data source

Reference

Reference Type:

publication

Title:

Toxicity and Teratogenicety of Aromatic amines to Xenopus laevis

Author:

Dumont JN, Schultz TW, Jones RD

Year:

1979

Bibliographic source:

Bull Env contam toxicol 22: 159-166

Materials and methods

Test guideline

Qualifier:

no guideline available

Principles of method if other than guideline:

Exposure of Xenopus embryos to different concentrations of quinoline for 96 h

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Quinoline

EC Number:

202-051-6

EC Name:

Quinoline

Cas Number:

91-22-5

Molecular formula:

C9H7N

IUPAC Name:

quinoline

Details on test material:

no data

Sampling and analysis

Analytical monitoring:

no

Test solutions

Vehicle:

no

Test organisms

Test organisms (species):

Xenopus laevis

Study design

Test type:

static

Water media type:

freshwater

Limit test:

no

Total exposure duration:

96 h

Results and discussion

Effect concentrations

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

26.3 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality

Remarks on result:

other: 22.1-31.3 mg/L

Any other information on results incl. tables

Table 1: Lethality and teratogenic effects of quinoline

Conc. mg/L	24 h		48 h		72 h		96 h
	A/S	%	A/S	%	A/S	%	A/S	%	Dead + abnormal (%)
0	0/100	0	0/96	0	2/96	2	3/96	3	7
10	0/96	0	1/95	1	3/95	3	3/95	3	8
25	3/93	3	20/91	22	30/86	35	37/86	43	51
50	6/93	6	39/87	44	49/83	59	56/83	67	73
75	6/96	6	46/86	53	63/86	72	68/86	79	82
100	12/86	14	46/63	73	60/62	97	62/62	100	100
125	14/77	18	14/14	100	0/0		0/0		0

A/S = abnormal / survivors

Applicant's summary and conclusion

Validity criteria fulfilled:

not applicable

Remarks:

no validity criteria available

Conclusions:

The LC50 (96 h) on xenopus embryos is 26.3 mg/L.

Executive summary:

An acute toxicity test of quinoline on embryos of Xenopus laevis has been determined after exposure for 96 h to different concentrations.

The teratogenic effetcs were also recorded.

The LC50 (96h) is 26.3 mg/L.