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EC number: 202-051-6 | CAS number: 91-22-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Jun-Jul 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study not performed according to GLP but it is similar to the OECD 402 guideline however the substance tested is poorly described.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Quinoline
- EC Number:
- 202-051-6
- EC Name:
- Quinoline
- Cas Number:
- 91-22-5
- Molecular formula:
- C9H7N
- IUPAC Name:
- quinoline
- Details on test material:
- - Name of test material (as cited in study report): 110.831
- Substance type: no data
- Physical state: yellowish liquid
- Analytical purity: no data
- Impurities (identity and concentrations): no data
- Composition of test material, percentage of components: no data
- Isomers composition: no data
- Purity test date: no data
- Lot/batch No.: no data
- Expiration date of the lot/batch: not determined
- Stability under test conditions: no data
- Storage condition of test material: at room temperature, day light
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Dr A Ivanovas, Kissleg/Allgäu
- Age at study initiation: no data
- Weight at study initiation: male: 220-270 g, female: 200-245 g
- Fasting period before study: no data
- Housing: individually
- Diet: Ssniff R10 (pellets) ad libitum
- Water (e.g. ad libitum): yes
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 1
- Humidity (%): no data
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: June To: July 1981
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- polyethylene glycol
- Details on dermal exposure:
- TEST SITE
- Area of exposure: back, area 5 x 7.5 cm
- % coverage: no data
- Type of wrap if used: aluminium foil and "Elastoplast"
REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes with lukewarm water
- Time after start of exposure: 24 h
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 3 mL / kg
- Concentration (if solution): no data
- Constant volume: yes
VEHICLE
- Amount(s) applied (volume or weight with unit): no data
- Concentration (if solution): no data
- Lot/batch no. (if required): no data
- Purity: no data - Duration of exposure:
- 24 h
- Doses:
- 0.82 - 1.0 - 1.21 - 1.47 mL/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: once a day for observations, at day 1, 7 and 15 for weighing
- Necropsy of survivors performed: yes - Statistics:
- Finney method
Results and discussion
- Preliminary study:
- not relevant
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1.26 mL/kg bw
- 95% CL:
- 1.15 - 1.39
- Mortality:
- See table 1
- Clinical signs:
- other: Skin effect: Neither erythem nor oedema was observed. Clinical signs: Decrease of motility, abdominal posture of pre-agony.
- Gross pathology:
- No effects in the animal that died in the study.
Animals sacrified at the end of the study:
Dose 1 mL/kg: Pale discoloration of liver and kidneys, bloody aspect of the stomach and intestine content (1 female)
Dose 1.21 mL/kg: Autolysis (1 male), Pale discoloration of liver and kidneys, medium grade hyperemia of the lungs. Bloody aspect of the stomach and small intestine content (2 females)
Dose 1.47 mL/kg: Autolysis (2 males and 5 females), Pale discoloration of liver and kidneys (2 males), medium grade hyperemia of the lungs (2 males). Bloody aspect of the stomach (2 males and 3 females) and small intestine content (2 males). - Other findings:
- none
Any other information on results incl. tables
Table 1: Mortality
Time |
Control |
0.82 mL/kg |
1.0 mL/kg |
1.21 mL/kg |
1.47 mL/kg |
|
Up to 6h |
M |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
6-24h |
M |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
24-48h |
M |
0/5 |
0/5 |
0/5 |
0/5 |
4/5 |
3-7 d |
M |
0/5 |
0/5 |
0/5 |
1/5 |
0/5 |
7-14d |
M |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
Total |
M |
0/5 |
0/5 |
0/5 |
1/5 |
4/5 |
% | 0 | 0 | 10 | 30 | 90 |
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The dermal LD50 of quinoline in rat is 1377 mg/kg. Quinoline is harmful in contact with skin according to the 67/548/EEC directive and according to CLP (cat 4).
- Executive summary:
A standard dermal acute toxicity method has been performed with quinoline on rat. 5 animals per sex per group were treated by quinoline doses from 0.82 to 1.47 mL/kg bw. In these conditions, the LD50 is 1.26 mL/kg corresponding to 1377 mg/kg bw.
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