Registration Dossier
Registration Dossier
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EC number: 202-051-6 | CAS number: 91-22-5
Endpoint summary
Administrative data
Description of key information
Additional information
Acute toxicity
Quinoline shows a similar toxicity level on daphnia and fish (lowest L(E)C50 is around 25 -30 mg/L). Algae are less susceptible (EC50 = 66 mg/L).
The mode of action of quinoline is considered to be baseline toxicity according to ECOSAR model (neutral organics).
In addition to the standard test organisms, several invertebrate species have been studied. They usually show less toxicity effects than daphnia except Chironomus larvae (LC50 around 5 mg/L). The value has not been retained because these organisms are rather benthic than pelagic. They have been tested in water only so the test is considered as not valid.
The NOEC for the aquatic micro-organisms is 87 mg/L based on a study on inhibition of activated sludge respiration.
Long-term studies
Long-term NOEC are available on algae and daphnia, 30 and 0.8 mg/L respectively. The higher sensitivity of daphnia compared to algae observed in acute tests, is confirmed with the long-term NOEC.
No valid NOEC is available for fish. The available long-term fish tests were disregarded due to lack of information or to conditions which are not in conformity with OECD Guidelines. A waiving is proposed for long-term fish tests according to column 2, annex IX of REACh, since there is no concern for the environment in the CSA.
Remark : The French authorities (INERIS) made a proposal for the environmental classification of quinoline in 2005 (ECBI/09/06 Add.2). INERIS considered that the tests performed on embryo-larval stages of largemouth bass and rainbow trout were acute tests. However according to ECHA Guidance on information requirements and chemical safety assessment Chapter R7b (November 2012), this kind of test is related to long term tests because they include sublethal effects and they are performed on early life stages. Moreover following the comments sent by ECHA (ref CCH-D-0000003518-70-01/D) these long-term tests were disregarded due to lack of information (reliability 4) or to conditions which are not in conformity with OECD Guidelines (reliability 3).
Taking into account the available data in the updated IUCLID dossier which are a log Kow around 2, a ready biodegradation, acute aquatic LC50/IC50 > 10 mg/L and the lowest long-term NOEC on daphnia of 0.8 mg/L, Quinoline should be classified as Aquatic chronic 3.
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