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Diss Factsheets
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EC number: 202-051-6 | CAS number: 91-22-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- August 1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study performed according to a standard even if not EU, however the substance is poorly described, no observation is done at 48 h and after 72 h. The treatment duration is 24 h instead of 4.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: CFR Title 16, section 1500.41
- Principles of method if other than guideline:
- The exposure duration in this guideline is 24 h instead of 4 according to the OECD guideline.
- GLP compliance:
- no
Test material
- Reference substance name:
- Quinoline
- EC Number:
- 202-051-6
- EC Name:
- Quinoline
- Cas Number:
- 91-22-5
- Molecular formula:
- C9H7N
- IUPAC Name:
- quinoline
- Details on test material:
- - Name of test material (as cited in study report): 110 831
- Substance type: no data
- Physical state: no data
- Analytical purity: no data
- Impurities (identity and concentrations): no data
- Composition of test material, percentage of components: no data
- Isomers composition: no data
- Purity test date: no data
- Lot/batch No.: no data
- Expiration date of the lot/batch: no data
- Stability under test conditions: no data
- Storage condition of test material: no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: both intact and abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.5 mL
- Duration of treatment / exposure:
- 24 h
- Observation period:
- 72 h
- Number of animals:
- 6
- Details on study design:
- TEST SITE
- Area of exposure: 1 inch x 1 inch (around 2.5 cm x 2.5 cm)
- % coverage: no data
- Type of wrap if used: the patch is secured in place by adhesive tape. The entire trunk of the animal is then wrapped with an impervious material such as rubberized cloth.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): no data
- Time after start of exposure: 24 h
SCORING SYSTEM: Draize score
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Remarks:
- intact skin
- Basis:
- mean
- Time point:
- other: 24-72 h
- Score:
- 0.9
- Max. score:
- 3
- Reversibility:
- not reversible
- Remarks:
- over 72 h
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24-72 h
- Score:
- 1.5
- Max. score:
- 3
- Reversibility:
- not reversible
- Remarks:
- over 72 h
- Other effects:
- 1 animal died during the study
Any other information on results incl. tables
Animal |
Effect |
24 h |
72 h |
||
Left side (intact) |
Right side (abraded) |
Left side (intact) |
Right side (abraded) |
||
1 |
Erythema |
1 |
1 |
1 |
1 |
Oedema |
2 |
2 |
1 |
1 |
|
2 |
Erythema |
0 |
0 |
0 |
0 |
Oedema |
2 |
2 |
0 |
0 |
|
3 |
Erythema |
0 |
0 |
1 |
1 |
Oedema |
1 |
1 |
1 |
1 |
|
4 |
Erythema |
1 |
1 |
2 |
2 |
Oedema |
3 |
3 |
1 |
1 |
|
5* |
Erythema |
- |
- |
- |
- |
Oedema |
- |
- |
- |
- |
|
6 |
Erythema |
0 |
0 |
3 |
3 |
Oedema |
2 |
2 |
2 |
2 |
*Animal 5 died during the study
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- After exposure for 24 h, the mean scores are below 2 but the effects are not reversible over 72h, so the substance is considered as irritating R38 according to 67/548/EEC directive, and according to CLP (cat 2).
- Executive summary:
The skin irritation properties of quinoline have been assessed in a test on 6 rabbits according to a US guideline (CFR Title 16, section 1500.41). The exposure duration was 24 h. The effects were observed at 24 and 72 h only. 1 rabbit died during the test.
The mean erythema score over 24 -72 h is 0.9 on intact skin and the mean oedema score is 1.5. However, the effects are not reversible at the end of the 72 h period, so the product is considered as irritating for the skin.
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