Registration Dossier
Registration Dossier
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EC number: 202-051-6 | CAS number: 91-22-5
Specific investigations: other studies
Administrative data
- Endpoint:
- biochemical or cellular interactions
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- No data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well described study.
Data source
Reference
- Reference Type:
- publication
- Title:
- Activation of the Human Ah Receptor by Aza-Polycyclic Aromatic Hydrocarbons and Their Halogenated Derivatives
- Author:
- Saeki K, Matsuda T, Kato T, Yamada K, Mizutani T, Matsui S, Fukuhara K, Miyata N
- Year:
- 2 003
- Bibliographic source:
- Biol Pharm Bull 26(4):448-452
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- AhR ligand activity was measured by using the yeast AhR signaling assay. The genes of the human AhR and its heterodimer partner, AhR nuclear translocator (Arnt), are co-expressed, and AhR ligand activity can be detected and quantified by measuring the beta-galactosidase activity resulting by AhR-mediated transcriptional activation of a lacZ reporter plasmid.
- GLP compliance:
- not specified
- Type of method:
- in vitro
- Endpoint addressed:
- not applicable
Test material
- Reference substance name:
- Quinoline
- EC Number:
- 202-051-6
- EC Name:
- Quinoline
- Cas Number:
- 91-22-5
- Molecular formula:
- C9H7N
- IUPAC Name:
- quinoline
- Details on test material:
- Supplier: Aldrich
No further data
Constituent 1
Administration / exposure
- Route of administration:
- other: incubation
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- no
- Duration of treatment / exposure:
- see below
- Frequency of treatment:
- once
- Post exposure period:
- none
Doses / concentrations
- Remarks:
- Doses / Concentrations:
50 to 500 µM
Basis:
- No. of animals per sex per dose:
- not relevant
Examinations
- Examinations:
- not relevant
- Positive control:
- benzo[a]pyrene
Results and discussion
- Details on results:
- Concentration producing lacZ units equal to 50% of the max response of the positive substance: EC(BAP50) > 500 µM for quinoline.
Applicant's summary and conclusion
- Conclusions:
- Quinoline is about three orders of magnitude less active than BaP.
- Executive summary:
Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor through which dioxins and carcinogenic polycyclic aromatic hydrocarbons cause altered gene expression and toxicity.
A screening assay has been performed using the yeast AhR signaling assay.
Quinoline does not activate this receptor in a significant extent.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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