Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-051-6 | CAS number: 91-22-5
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- no data
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: The rationale for the dose selection is not known, the exposure duration is not justified and was maybe too short to properly induce the enzyme activity.
Data source
Reference
- Reference Type:
- publication
- Title:
- MUTAGENICITY OF QUINOLINES AND THEIR EFFECT ON RAT LUNG AND LIVER ARYL HYDROCARBON HYDROXYLASE ACTIVITY
- Author:
- Benson J, Kubrick R
- Year:
- 1 979
- Bibliographic source:
- annual report of the Inhalation toxicology research institute (Lovelace Biomedical and environmental research institute): 391-396
Materials and methods
- Type of study / information:
- Activity of an enzyme (Aryl hydrocarbon hydroxylase) in liver and lung of rat after exposure to quinoline
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Exposure of the animals in vivo and then sacrifice and activity determination in the organs.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Quinoline
- EC Number:
- 202-051-6
- EC Name:
- Quinoline
- Cas Number:
- 91-22-5
- Molecular formula:
- C9H7N
- IUPAC Name:
- quinoline
- Details on test material:
- quinoline was of the highest purity available from the manufacturer and was used without further purification. No further data
Constituent 1
Results and discussion
Any other information on results incl. tables
Activity (mmol/mg protein/min)
Inducing agent |
Intratracheal instillation |
Intraperitoneal injection |
Vehicle control |
||
Lung |
0.01 ± 0.01 (n = 11) |
- |
Liver |
0.42 ± 0.19 |
0.39 ± 0.08 (n = 3) |
Quinoline |
||
Lung |
0.015 ± 0.02 (n = 4) |
- |
Liver |
0.61 ± 0.31 |
0.52 ± 0.14 (n = 3) |
None of the result is statistically significant
Applicant's summary and conclusion
- Conclusions:
- Quinoline didn't induced the activity of aryl hydrocarbon hydroxylase in the conditions of the test.
- Executive summary:
Quinoline was administered to rats either by ip or intratracheal instillation. Liver and lungs were analysed for AHH activity 24 h later.
Quinoline did not induce the activity of this enzyme in the conditions of the test.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
