Registration Dossier

Administrative data

Endpoint:
additional toxicological information
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
no data
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: The rationale for the dose selection is not known, the exposure duration is not justified and was maybe too short to properly induce the enzyme activity.

Data source

Reference
Reference Type:
publication
Title:
MUTAGENICITY OF QUINOLINES AND THEIR EFFECT ON RAT LUNG AND LIVER ARYL HYDROCARBON HYDROXYLASE ACTIVITY
Author:
Benson J, Kubrick R
Year:
1979
Bibliographic source:
annual report of the Inhalation toxicology research institute (Lovelace Biomedical and environmental research institute): 391-396

Materials and methods

Type of study / information:
Activity of an enzyme (Aryl hydrocarbon hydroxylase) in liver and lung of rat after exposure to quinoline
Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Exposure of the animals in vivo and then sacrifice and activity determination in the organs.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
quinoline was of the highest purity available from the manufacturer and was used without further purification. No further data

Results and discussion

Any other information on results incl. tables

Activity (mmol/mg protein/min)

Inducing agent

Intratracheal instillation

Intraperitoneal injection

Vehicle control

Lung

0.01 ± 0.01 (n = 11)

-

Liver

0.42 ± 0.19

0.39 ± 0.08 (n = 3)

Quinoline

Lung

0.015 ± 0.02 (n = 4)

-

Liver

0.61 ± 0.31

0.52 ± 0.14 (n = 3)

None of the result is statistically significant

Applicant's summary and conclusion

Conclusions:
Quinoline didn't induced the activity of aryl hydrocarbon hydroxylase in the conditions of the test.
Executive summary:

Quinoline was administered to rats either by ip or intratracheal instillation. Liver and lungs were analysed for AHH activity 24 h later.

Quinoline did not induce the activity of this enzyme in the conditions of the test.