Registration Dossier

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
No data
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Very few details in this old study

Data source

Reference
Reference Type:
publication
Title:
The toxic effects of amines
Author:
Johnston AR
Year:
1928
Bibliographic source:
The Journal of Infectious diseases 42:473-484

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
No guideline was available when the study has been performed. The design of the study is not similar to the current guideline but the data about the effects are valid
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
No data

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
water
Doses:
0.3 mL of a saturated solution
No. of animals per sex per dose:
1 in total
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
other: test with 1 dose

Any other information on results incl. tables

The dose produced general anaesthesia in 30minutes. The animal remained in this state until death 24 hours later

Quinoline produces a flaccid state in rabbits but the heart's action is not so irregular. Cardiac activity continues for some time after respiratory cessation and loss of corneal reflex. The bladder urine reduces Fehling's solution. Quinoline by itself does so but the bladder urine was negative to quinoline tests.

Applicant's summary and conclusion

Conclusions:
Quinoline produces anaesthesia .
Executive summary:

1 rabbit was injected (ip) with 1 lethal dose of quinoline. Quinoline produces anaesthesia before death.