Registration Dossier
Registration Dossier
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EC number: 202-051-6 | CAS number: 91-22-5
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- No data
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Very few details in this old study
Data source
Reference
- Reference Type:
- publication
- Title:
- The toxic effects of amines
- Author:
- Johnston AR
- Year:
- 1 928
- Bibliographic source:
- The Journal of Infectious diseases 42:473-484
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- No guideline was available when the study has been performed. The design of the study is not similar to the current guideline but the data about the effects are valid
- GLP compliance:
- no
Test material
- Reference substance name:
- Quinoline
- EC Number:
- 202-051-6
- EC Name:
- Quinoline
- Cas Number:
- 91-22-5
- Molecular formula:
- C9H7N
- IUPAC Name:
- quinoline
- Details on test material:
- No data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- water
- Doses:
- 0.3 mL of a saturated solution
- No. of animals per sex per dose:
- 1 in total
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- other: test with 1 dose
Any other information on results incl. tables
The dose produced general anaesthesia in 30minutes. The animal remained in this state until death 24 hours later
Quinoline produces a flaccid state in rabbits but the heart's action is not so irregular. Cardiac activity continues for some time after respiratory cessation and loss of corneal reflex. The bladder urine reduces Fehling's solution. Quinoline by itself does so but the bladder urine was negative to quinoline tests.
Applicant's summary and conclusion
- Conclusions:
- Quinoline produces anaesthesia .
- Executive summary:
1 rabbit was injected (ip) with 1 lethal dose of quinoline. Quinoline produces anaesthesia before death.
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