Registration Dossier

Administrative data

Hazard for aquatic organisms

Freshwater

Hazard assessment conclusion:
PNEC aqua (freshwater)
PNEC value:
0.016 mg/L
Assessment factor:
50
Extrapolation method:
assessment factor

Marine water

Hazard assessment conclusion:
PNEC aqua (marine water)
PNEC value:
0.002 mg/L
Assessment factor:
500
Extrapolation method:
assessment factor

STP

Hazard assessment conclusion:
PNEC STP
PNEC value:
8.7 mg/L
Assessment factor:
10
Extrapolation method:
assessment factor

Sediment (freshwater)

Hazard assessment conclusion:
PNEC sediment (freshwater)
PNEC value:
0.317 mg/kg sediment dw
Extrapolation method:
equilibrium partitioning method

Sediment (marine water)

Hazard assessment conclusion:
PNEC sediment (marine water)
PNEC value:
0.032 mg/kg sediment dw
Extrapolation method:
equilibrium partitioning method

Hazard for air

Air

Hazard assessment conclusion:
no hazard identified

Hazard for terrestrial organisms

Soil

Hazard assessment conclusion:
PNEC soil
PNEC value:
0.53 mg/kg soil dw
Assessment factor:
100
Extrapolation method:
assessment factor

Hazard for predators

Secondary poisoning

Hazard assessment conclusion:
no potential for bioaccumulation

Additional information

Conclusion on classification

The current quinoline classification reported in Annex VI of Regulation (EC) No 1272/2008 (CLP Regulation), is “aquatic chronic 2”; it corresponds to the translation in CLP of the classification “N R51/53” (31st ATP of the directive 67/548/EEC). However, as explained in the aquatic toxicity summary, the lowest LC50 used was based on a toxicity study (OECD 212) that is to be considered as long-term study according to the Guidance on data requirements and chemical safety assessment (Novembre 2012). In addition following the comments sent by ECHA (ref CCH-D-0000003518-70-01/D), this OECD study ‘” fish short-term toxicity test on embryo and sac-fry stages” was considered as not reliable on the basis of the Klimisch criteria (reliability 3 for rainbow trout and reliability 4 for largemouth bass). 

 

The acute toxicity level is between 10 and 100 mg/L for the 3 trophic levels, and the lowest long-term data is 0.8 mg/L on Daphnia magna. Quinoline has a low potential for bioaccumulation and it is considered as readily biodegradable based on the soil biodegradation study. On the basis of the long-term data on daphnia, Quinoline should be classified as “Aquatic chronic 3”.