Registration Dossier
Registration Dossier
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EC number: 202-051-6 | CAS number: 91-22-5
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 0.016 mg/L
- Assessment factor:
- 50
- Extrapolation method:
- assessment factor
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 0.002 mg/L
- Assessment factor:
- 500
- Extrapolation method:
- assessment factor
STP
- Hazard assessment conclusion:
- PNEC STP
- PNEC value:
- 8.7 mg/L
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
Sediment (freshwater)
- Hazard assessment conclusion:
- PNEC sediment (freshwater)
- PNEC value:
- 0.317 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Sediment (marine water)
- Hazard assessment conclusion:
- PNEC sediment (marine water)
- PNEC value:
- 0.032 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- PNEC soil
- PNEC value:
- 0.53 mg/kg soil dw
- Assessment factor:
- 100
- Extrapolation method:
- assessment factor
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- no potential for bioaccumulation
Additional information
Conclusion on classification
The current quinoline classification reported in Annex VI of Regulation (EC) No 1272/2008 (CLP Regulation), is “aquatic chronic 2”; it corresponds to the translation in CLP of the classification “N R51/53” (31st ATP of the directive 67/548/EEC). However, as explained in the aquatic toxicity summary, the lowest LC50 used was based on a toxicity study (OECD 212) that is to be considered as long-term study according to the Guidance on data requirements and chemical safety assessment (Novembre 2012). In addition following the comments sent by ECHA (ref CCH-D-0000003518-70-01/D), this OECD study ‘” fish short-term toxicity test on embryo and sac-fry stages” was considered as not reliable on the basis of the Klimisch criteria (reliability 3 for rainbow trout and reliability 4 for largemouth bass).
The acute toxicity level is between 10 and 100 mg/L for the 3 trophic levels, and the lowest long-term data is 0.8 mg/L on Daphnia magna. Quinoline has a low potential for bioaccumulation and it is considered as readily biodegradable based on the soil biodegradation study. On the basis of the long-term data on daphnia, Quinoline should be classified as “Aquatic chronic 3”.
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